. "Hertlov\u00E1, Milu\u0161e" . "P\u00E1cal, Luk\u00E1\u0161" . . "369129" . "[6863A89B11EC]" . "P(NR9443)" . "Tanh\u00E4userov\u00E1, Veronika" . . . "Introduction and Aims: Variable degree of more or less permanent hyperglycemia characterising diabetes mellitus (DM) is causally responsible for the development of diabetic complications including diabetic nephropathy (DN). Complex dysregulation of cellular metabolism during hyperglycemia - especially accumulation of proximal glycolytic intermediates - provides substrates for certain alternative metabolic pathways (polyol, hexosamine, non-enzymatic glycation etc.) giving rise to harmful moieties (advanced glycation end-products, dicarbonyls, sorbitol, hexosamines, reactive oxygen and nitrogen species etc.). Pentose phosphate pathway (PPP) represents potentially protective mechanism in hyperglycemia since shunting of cumulated glycolytic intermediates (esp. triosephosphates) into the PPP reactions supposedly disburdens glycolysis and quantitatively limits processing of glycolytic intermediates in the alternative metabolic pathways."@en . . . . "diabetic nephropathy; pentose phosphate pathway; transketolase"@en . . . "Ka\u0148kov\u00E1, Kate\u0159ina" . . . . "Ol\u0161ovsk\u00FD, Jind\u0159ich" . . "Krusov\u00E1, Darja" . "Genetic variability in the pentose phosphate cycle enzymes as a treatment-independent modifier of hyperglycemia toxicity in diabetic nephropathy" . . "14110" . . "Genetic variability in the pentose phosphate cycle enzymes as a treatment-independent modifier of hyperglycemia toxicity in diabetic nephropathy"@en . . "6"^^ . "Genetic variability in the pentose phosphate cycle enzymes as a treatment-independent modifier of hyperglycemia toxicity in diabetic nephropathy" . "Introduction and Aims: Variable degree of more or less permanent hyperglycemia characterising diabetes mellitus (DM) is causally responsible for the development of diabetic complications including diabetic nephropathy (DN). Complex dysregulation of cellular metabolism during hyperglycemia - especially accumulation of proximal glycolytic intermediates - provides substrates for certain alternative metabolic pathways (polyol, hexosamine, non-enzymatic glycation etc.) giving rise to harmful moieties (advanced glycation end-products, dicarbonyls, sorbitol, hexosamines, reactive oxygen and nitrogen species etc.). Pentose phosphate pathway (PPP) represents potentially protective mechanism in hyperglycemia since shunting of cumulated glycolytic intermediates (esp. triosephosphates) into the PPP reactions supposedly disburdens glycolysis and quantitatively limits processing of glycolytic intermediates in the alternative metabolic pathways." . "RIV/00216224:14110/08:00028212!RIV10-MZ0-14110___" . . . . "6"^^ . . "Genetic variability in the pentose phosphate cycle enzymes as a treatment-independent modifier of hyperglycemia toxicity in diabetic nephropathy"@en . "RIV/00216224:14110/08:00028212" .