. "[9839B2C12C04]" . . "Praha" . "\u0160toura\u010D, Pavel" . . . "RIV/00216224:14110/08:00026920" . "2008-11-27+01:00"^^ . . "Immunoregulatory lymphocytes; multiple sclerosis"@en . "Olomouc" . . . . "\u010Cesk\u00E1 l\u00E9ka\u0159sk\u00E1 spole\u010Dnost J. E. Purkyn\u011B" . . "Praksov\u00E1, Petra" . "1210-7859" . . . "Roztrou\u0161en\u00E1 skler\u00F3za je chronick\u00E9 autoimunitn\u00ED onemocn\u011Bn\u00ED charakterizovan\u00E9 mnoho\u010Detn\u00FDmi z\u00E1n\u011Btliv\u00FDmi lo\u017Eisky v b\u00EDl\u00E9 hmot\u011B mozku a m\u00EDchy. V patogenezi tohoto onemocn\u011Bn\u00ED hraje d\u016Fle\u017Eitou roli dysregulace imunitn\u00EDho syst\u00E9mu, kter\u00E1 umo\u017E\u0148uje autoagresivn\u00EDm T lymfocyt\u016Fm reagovat s antigeny centr\u00E1ln\u00EDho nervov\u00E9ho syst\u00E9mu. Za zaji\u0161t\u011Bn\u00ED autotolerance jsou zodpov\u011Bdn\u00E9 regula\u010Dn\u00ED T lymfocyty (Th3 bu\u0148ky, Treg bu\u0148ky), jejich\u017E deficit byl pops\u00E1n u \u0159ady autoimunitn\u00EDch onemocn\u011Bn\u00ED. C\u00EDlem na\u0161\u00ED studie je zjistit zastoupen\u00ED jednotliv\u00FDch subpopulac\u00ED T lymfocyt\u016F a jejich ovlivn\u011Bn\u00ED l\u00E9\u010Dbou u pacient\u016F s roztrou\u0161enou skler\u00F3zou ve srovn\u00E1n\u00ED se zdrav\u00FDmi jedinci. Metodika Do studie jsou za\u0159azov\u00E1ni pacienti s remitentn\u011B relabuj\u00EDc\u00EDm pr\u016Fb\u011Bhem roztrou\u0161en\u00E9 skler\u00F3zy s EDSS m\u00E9n\u011B ne\u017E 4,5, kte\u0159\u00ED za\u010D\u00EDnaj\u00ED s imunomodula\u010Dn\u00ED l\u00E9\u010Dbou. Vylu\u010Dovac\u00EDm krit\u00E9riem pro za\u0159azen\u00ED do studie je p\u0159edchoz\u00ED l\u00E9\u010Dba kortikoidy \u010Di jin\u00FDmi imunomodula\u010Dn\u00EDmi prepar\u00E1ty v posledn\u00EDch 30 dnech a z\u00E1n\u011Btliv\u00E9 a n\u00E1dorov\u00E9 onemocn\u011Bn\u00ED."@cs . "Z(MSM0021622404)" . . . "Immunoregulatory T lymphocytes in multiple sclerosis"@en . "Imunoregula\u010Dn\u00ED T-lymfocyty u pacient\u016F s roztrou\u0161enou skler\u00F3zou"@cs . . "1"^^ . "Imunoregula\u010Dn\u00ED T-lymfocyty u pacient\u016F s roztrou\u0161enou skler\u00F3zou" . "\u010Cesk\u00E1 a slovensk\u00E1 neurologie a neurochirurgie" . . "Immunoregulatory T lymphocytes in multiple sclerosis"@en . "RIV/00216224:14110/08:00026920!RIV10-MSM-14110___" . . "Background: Multiple sclerosis (MS) is a chronic disease characterized by demyelination and chronic inflamation of the central nervous system (CNS). Many of the immune cells including T cells, B cells seem to be involved in disease pathogenesis by inducing or controlling the immune responses in the nervous system of MS patients. The aim of our research was to study subpopulations of T cells in newly diagnosed MS patients. Material and methods: Fifty eight patients with relapsing-remitting MS (RRMS; age 17 - 57 years, median 32 years) were included in the study. These patients were newly diagnosed of RRMS. Expanded disability status scale (EDSS) was recorded in all patients at the Department of Neurology, University Hospital Brno. Patients were excluded from the study if they had previously received IFN beta 1a, IFN beta 1b or glatiramer acetate. None of the patients received any immunomodulatory or immunosuppressive drugs at least 30 days before blood sample was taken for the purpose of the study."@en . "Mich\u00E1lek, Jaroslav" . . "5"^^ . "Bedna\u0159\u00EDk, Josef" . "5"^^ . "371750" . "Imunoregula\u010Dn\u00ED T-lymfocyty u pacient\u016F s roztrou\u0161enou skler\u00F3zou" . . . "14110" . "Imunoregula\u010Dn\u00ED T-lymfocyty u pacient\u016F s roztrou\u0161enou skler\u00F3zou"@cs . "Roztrou\u0161en\u00E1 skler\u00F3za je chronick\u00E9 autoimunitn\u00ED onemocn\u011Bn\u00ED charakterizovan\u00E9 mnoho\u010Detn\u00FDmi z\u00E1n\u011Btliv\u00FDmi lo\u017Eisky v b\u00EDl\u00E9 hmot\u011B mozku a m\u00EDchy. V patogenezi tohoto onemocn\u011Bn\u00ED hraje d\u016Fle\u017Eitou roli dysregulace imunitn\u00EDho syst\u00E9mu, kter\u00E1 umo\u017E\u0148uje autoagresivn\u00EDm T lymfocyt\u016Fm reagovat s antigeny centr\u00E1ln\u00EDho nervov\u00E9ho syst\u00E9mu. Za zaji\u0161t\u011Bn\u00ED autotolerance jsou zodpov\u011Bdn\u00E9 regula\u010Dn\u00ED T lymfocyty (Th3 bu\u0148ky, Treg bu\u0148ky), jejich\u017E deficit byl pops\u00E1n u \u0159ady autoimunitn\u00EDch onemocn\u011Bn\u00ED. C\u00EDlem na\u0161\u00ED studie je zjistit zastoupen\u00ED jednotliv\u00FDch subpopulac\u00ED T lymfocyt\u016F a jejich ovlivn\u011Bn\u00ED l\u00E9\u010Dbou u pacient\u016F s roztrou\u0161enou skler\u00F3zou ve srovn\u00E1n\u00ED se zdrav\u00FDmi jedinci. Metodika Do studie jsou za\u0159azov\u00E1ni pacienti s remitentn\u011B relabuj\u00EDc\u00EDm pr\u016Fb\u011Bhem roztrou\u0161en\u00E9 skler\u00F3zy s EDSS m\u00E9n\u011B ne\u017E 4,5, kte\u0159\u00ED za\u010D\u00EDnaj\u00ED s imunomodula\u010Dn\u00ED l\u00E9\u010Dbou. Vylu\u010Dovac\u00EDm krit\u00E9riem pro za\u0159azen\u00ED do studie je p\u0159edchoz\u00ED l\u00E9\u010Dba kortikoidy \u010Di jin\u00FDmi imunomodula\u010Dn\u00EDmi prepar\u00E1ty v posledn\u00EDch 30 dnech a z\u00E1n\u011Btliv\u00E9 a n\u00E1dorov\u00E9 onemocn\u011Bn\u00ED." . "Mikulkov\u00E1, Zuzana" .