"0009-2770" . . "000257129500004" . "Slaninov\u00E1, Iva" . . "[DB8DBD8411AF]" . . "P(GA525/08/0819), P(LC06077), Z(MSM0021622415)" . "Fluorescen\u010Dn\u00ED vlastnosti kvart\u00E9rn\u00EDch benzo[c]fenanthridinov\u00FDch alkaloid\u016F a jejich vyu\u017Eit\u00ED jako supravit\u00E1ln\u00EDch DNA sond." . "Fluorescence properties of quaternary benzo[c]fenanthridine alkaloids and their use as a supravital DNA probes.Chemick\u00E9"@en . . "102" . . . . . "CZ - \u010Cesk\u00E1 republika" . "Slanina, Ji\u0159\u00ED" . "benzo[c]phenanthridine alkaloids; macarpin; cell cycle; DNA probe"@en . "Chemick\u00E9 listy" . . . "Fluorescen\u010Dn\u00ED vlastnosti kvart\u00E9rn\u00EDch benzo[c]fenanthridinov\u00FDch alkaloid\u016F a jejich vyu\u017Eit\u00ED jako supravit\u00E1ln\u00EDch DNA sond."@cs . . "Quaternary benzo[c]phenanthridine alkaloids (QBAs) are natural products isolated from plants of Fumariaceae, Papaveraceae, Ranunculaceae and Rutaceae families. They are intensively studied for their biological activities. Nevertheless they have also attractive fluorescence properties. Chromophores responsible for fluorescence are fused aromatic rings with electron-donor groups containing oxygen (OH; OCH3; OCH2O). Recently we have described fluorescent characteristics of QBAs - macarpine (MA), sanguirubine (SR), chelirubine (CHR), sanguilutine (SL), chelilutine (CHL), sanguinarine (SA) and chelerythrine (CHE) upon interacting with living cells. All these alkaloids immediately enter living cells and MA, CHR and SA bound DNA and showed nuclear architecture similar as common DNA dyes. Moreover, MA binds DNA stoichiometrically and can rapidly report the cellular DNA content in living cells at a resolution level adequate for cell cycle analysis."@en . . . . "14110" . "368242" . "RIV/00216224:14110/08:00025258" . "7"^^ . "102" . "Pr\u00E1ce popisuje mo\u017Enost uplatn\u011Bn\u00ED qvart\u00E9rn\u00EDch benzo(c)fenantridinov\u00FDch alkaloid\u016F, p\u0159edev\u0161\u00EDm makarpinu, jako supravit\u00E1ln\u00EDch fluorescen\u010Dn\u00EDch DNA sond vhodn\u00FDch pro fluorwscen\u010Dn\u00ED mikroskopii a pr\u016Ftokovou cytometrii."@cs . "Fluorescen\u010Dn\u00ED vlastnosti kvart\u00E9rn\u00EDch benzo[c]fenanthridinov\u00FDch alkaloid\u016F a jejich vyu\u017Eit\u00ED jako supravit\u00E1ln\u00EDch DNA sond." . . . . "Pr\u00E1ce popisuje mo\u017Enost uplatn\u011Bn\u00ED qvart\u00E9rn\u00EDch benzo(c)fenantridinov\u00FDch alkaloid\u016F, p\u0159edev\u0161\u00EDm makarpinu, jako supravit\u00E1ln\u00EDch fluorescen\u010Dn\u00EDch DNA sond vhodn\u00FDch pro fluorwscen\u010Dn\u00ED mikroskopii a pr\u016Ftokovou cytometrii." . "Fluorescence properties of quaternary benzo[c]fenanthridine alkaloids and their use as a supravital DNA probes.Chemick\u00E9"@en . . . . "Fluorescen\u010Dn\u00ED vlastnosti kvart\u00E9rn\u00EDch benzo[c]fenanthridinov\u00FDch alkaloid\u016F a jejich vyu\u017Eit\u00ED jako supravit\u00E1ln\u00EDch DNA sond."@cs . "T\u00E1borsk\u00E1, Eva" . "3"^^ . "RIV/00216224:14110/08:00025258!RIV10-GA0-14110___" . . "3"^^ .