"P(KJB501620601), Z(MSM0021620807)" . . "Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene" . "Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene"@en . "6"^^ . . "Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene" . "diabetes mellitus; soluble RAGE; AGEs; diabetic nephropathy; glomerular filtration rate"@en . . . "Ol\u0161ovsk\u00FD, Jind\u0159ich" . . "2" . . "395824" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "14110" . "[3DE37458B286]" . "Zima, Tom\u00E1\u0161" . . "Krusov\u00E1, Darja" . . . . "Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of Advanced Glycation End products (AGEs) exerting their adverse effects via Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects. Study comprised a total of 265 diabetics (type 1 or 2 or LADA) with normoalbuminuria (n=94) or DN (n=171). sRAGE (assessed by ELISA) was significantly higher in DN than normoalbuminuria subjects (P=0.007) and positively correlated with age, S-urea, S-creatinine and albuminuria and AGEs (determined spectrofluorimetrically), negatively with GFR (all P<0.05); however, multivariate regression revealed that GFR was the only independent variable associated with sRAGE (P=0.047)." . "Hertlov\u00E1, Milu\u0161e" . . "RIV/00216224:14110/08:00024150!RIV10-AV0-14110___" . "Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of Advanced Glycation End products (AGEs) exerting their adverse effects via Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects. Study comprised a total of 265 diabetics (type 1 or 2 or LADA) with normoalbuminuria (n=94) or DN (n=171). sRAGE (assessed by ELISA) was significantly higher in DN than normoalbuminuria subjects (P=0.007) and positively correlated with age, S-urea, S-creatinine and albuminuria and AGEs (determined spectrofluorimetrically), negatively with GFR (all P<0.05); however, multivariate regression revealed that GFR was the only independent variable associated with sRAGE (P=0.047)."@en . "Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene"@en . . . "9"^^ . . . "1381-3455" . . "Arch Physiol Biochem" . "114" . "Kalousova, Marta" . . . "Ka\u0148kov\u00E1, Kate\u0159ina" . . "RIV/00216224:14110/08:00024150" . . . . "5"^^ .