"Otolaryngologie a foniatrie" . . "CZ - \u010Cesk\u00E1 republika" . . "1210-7867" . . "Jurajda, Michal" . . . . . . . "55" . "RIV/00216224:14110/06:00018860" . "Genetick\u00E9 a elektrofyziologick\u00E9 pozad\u00ED vn\u00EDm\u00E1n\u00ED tinnitu u pacient\u016F s kochle\u00E1rn\u00ED percep\u010Dn\u00ED poruchou sluchu"@cs . "RIV/00216224:14110/06:00018860!RIV10-MZ0-14110___" . "7"^^ . "4"^^ . "Rottenberg, Jan" . . "Genetick\u00E9 a elektrofyziologick\u00E9 pozad\u00ED vn\u00EDm\u00E1n\u00ED tinnitu u pacient\u016F s kochle\u00E1rn\u00ED percep\u010Dn\u00ED poruchou sluchu"@cs . . "Genetic and Electophysiologic Background of Tinnitus Perception in Patients with Cohlear Perception Disorder of Hearing"@en . "Soubor 105 pacient\u016F s kochle\u00E1rn\u00ED percep\u010Dn\u00ED poruchou sluchu byl sledov\u00E1n z hlediska manifestace tinnitu, byly m\u011B\u0159eny BAEP a MLR a byla p\u00FArovedena anal\u00FDza genetick\u00FDch polymorfism\u016F TaqI polymorfismu DRD2 receptoru, +101C/T polymorfismu v 10. intronu a 1275 A/G polymorfismus GRIN2A podjednotky a 2664C/T polymordfismus GRIN2B podjednotky NMDA receptoru a CA repetitivn\u00ED sekvence v genu GABRbeta3 podjednotky pro GABA-A receptor. Byly nalezeny n\u00E1sleduj\u00EDc\u00ED z\u00E1vislosti: manifestace tinnitu korelovala s pom\u011Brem amplitud vln V/III (p<0,001) a amplitudou vlny Pa (p<0,001), manifestace tinnitu z\u00E1visela rovn\u011B\u017E na genotypu pro CA repetitivn\u00ED sekvenci pro GABRbeta3 podjednotku GABA-A receptoru (p=0,04)."@cs . . "Genetick\u00E9 a elektrofyziologick\u00E9 pozad\u00ED vn\u00EDm\u00E1n\u00ED tinnitu u pacient\u016F s kochle\u00E1rn\u00ED percep\u010Dn\u00ED poruchou sluchu" . "14110" . "4"^^ . . . "2" . . "A population of 105 patients was examined on the manifestation of tinnitus. During the examination the BAEP and MLR measurings were taken, and the analysis of nine genetic polymorphisms was carried out: Taq I polymorphism of the DRD2 receptor, two polymorphisms of the gene for the subunit GRIN2a, and the 2664 C/T polymorphism of the gene for GRIN2b subunit of the NMDA receptor, CA repetitive sequence in the gene for GABR\u00DF3 subunit for GABA-A receptor. The following relations were discovered: the manifestation of tinnitus correlated with the ratio of the amplitudes of V/III waves (p<0,001), and with the amplitude of the PA wave of the MLR (p<0,001). The manifestation of tinnitus also depended on the genotype of the CA repetitive sequence of the gene for GABR\u00DF3 sub-unit (p=0,04)."@en . "Genetic and Electophysiologic Background of Tinnitus Perception in Patients with Cohlear Perception Disorder of Hearing"@en . "[00FA8BC814B6]" . "Genetick\u00E9 a elektrofyziologick\u00E9 pozad\u00ED vn\u00EDm\u00E1n\u00ED tinnitu u pacient\u016F s kochle\u00E1rn\u00ED percep\u010Dn\u00ED poruchou sluchu" . "tinnitus BAEP MLR disinhibition genetic polymorhism GABA-A receptor"@en . "Kost\u0159ica, Rom" . "Soubor 105 pacient\u016F s kochle\u00E1rn\u00ED percep\u010Dn\u00ED poruchou sluchu byl sledov\u00E1n z hlediska manifestace tinnitu, byly m\u011B\u0159eny BAEP a MLR a byla p\u00FArovedena anal\u00FDza genetick\u00FDch polymorfism\u016F TaqI polymorfismu DRD2 receptoru, +101C/T polymorfismu v 10. intronu a 1275 A/G polymorfismus GRIN2A podjednotky a 2664C/T polymordfismus GRIN2B podjednotky NMDA receptoru a CA repetitivn\u00ED sekvence v genu GABRbeta3 podjednotky pro GABA-A receptor. Byly nalezeny n\u00E1sleduj\u00EDc\u00ED z\u00E1vislosti: manifestace tinnitu korelovala s pom\u011Brem amplitud vln V/III (p<0,001) a amplitudou vlny Pa (p<0,001), manifestace tinnitu z\u00E1visela rovn\u011B\u017E na genotypu pro CA repetitivn\u00ED sekvenci pro GABRbeta3 podjednotku GABA-A receptoru (p=0,04)." . "476887" . "P(NM7472)" . . "\u017Dallmann, Miroslav" .