. "P\u0159ikrylov\u00E1 Ku\u010Derov\u00E1, Hana" . . "Negativn\u00ED p\u0159\u00EDznaky jsou pova\u017Eov\u00E1ny za nejv\u00EDce perzistuj\u00EDc\u00ED a zneschop\u0148uj\u00EDc\u00ED komponentu schizofrenie. Jejich mo\u017Enost ovlivn\u011Bn\u00ED antipsychotiky z\u016Fst\u00E1v\u00E1 sporn\u00E1. Repetitivn\u00ED transkrani\u00E1ln\u00ED magnetick\u00E1 stimulace (rTMS) p\u0159edstavuje novou mo\u017Enost ovlivn\u011Bn\u00ED negativn\u00EDch p\u0159\u00EDznak\u016F schizofrenie. Teoretick\u00E9 zd\u016Fvodn\u011Bn\u00ED \u00FA\u010Dinnosti rTMS u negativn\u00EDch p\u0159\u00EDznak\u016F schizofrenie lze spat\u0159ovat ve skute\u010Dnosti, \u017Ee vysokofrekven\u010Dn\u00ED rTMS m\u00E1 aktiva\u010Dn\u00ED vliv na neurony mozkov\u00E9 k\u016Fry. Negativn\u00ED korelace mezi aktivitou front\u00E1ln\u00EDho kortexu a z\u00E1va\u017Enost\u00ED negativn\u00EDch p\u0159\u00EDznak\u016F byla opakovan\u011B prok\u00E1z\u00E1na. Dal\u0161\u00EDm nem\u00E9n\u011B v\u00FDznamn\u00FDm faktem je ovlivn\u011Bn\u00ED uvol\u0148ov\u00E1n\u00ED dopaminu mezolimbick\u00E9ho a mezostriat\u00E1ln\u00EDho mozkov\u00E9ho syst\u00E9mu vysokofrekven\u010Dn\u00ED stimulac\u00ED front\u00E1ln\u00EDho kortexu. Konzistentn\u00ED liter\u00E1rn\u00ED \u00FAdaje mapuj\u00EDc\u00ED danou t\u00E9matiku v klinick\u00E9 praxi prakticky neexistuj\u00ED." . . "CZ - \u010Cesk\u00E1 republika" . "Stimulace prefront\u00E1ln\u00EDho kortexu a l\u00E9\u010Dba negativn\u00EDch p\u0159\u00EDznak\u016F schizofrenie" . . "6"^^ . . . . "RIV/00216224:14110/06:00017937" . "501631" . "Negativn\u00ED p\u0159\u00EDznaky jsou pova\u017Eov\u00E1ny za nejv\u00EDce perzistuj\u00EDc\u00ED a zneschop\u0148uj\u00EDc\u00ED komponentu schizofrenie. Jejich mo\u017Enost ovlivn\u011Bn\u00ED antipsychotiky z\u016Fst\u00E1v\u00E1 sporn\u00E1. Repetitivn\u00ED transkrani\u00E1ln\u00ED magnetick\u00E1 stimulace (rTMS) p\u0159edstavuje novou mo\u017Enost ovlivn\u011Bn\u00ED negativn\u00EDch p\u0159\u00EDznak\u016F schizofrenie. Teoretick\u00E9 zd\u016Fvodn\u011Bn\u00ED \u00FA\u010Dinnosti rTMS u negativn\u00EDch p\u0159\u00EDznak\u016F schizofrenie lze spat\u0159ovat ve skute\u010Dnosti, \u017Ee vysokofrekven\u010Dn\u00ED rTMS m\u00E1 aktiva\u010Dn\u00ED vliv na neurony mozkov\u00E9 k\u016Fry. Negativn\u00ED korelace mezi aktivitou front\u00E1ln\u00EDho kortexu a z\u00E1va\u017Enost\u00ED negativn\u00EDch p\u0159\u00EDznak\u016F byla opakovan\u011B prok\u00E1z\u00E1na. Dal\u0161\u00EDm nem\u00E9n\u011B v\u00FDznamn\u00FDm faktem je ovlivn\u011Bn\u00ED uvol\u0148ov\u00E1n\u00ED dopaminu mezolimbick\u00E9ho a mezostriat\u00E1ln\u00EDho mozkov\u00E9ho syst\u00E9mu vysokofrekven\u010Dn\u00ED stimulac\u00ED front\u00E1ln\u00EDho kortexu. Konzistentn\u00ED liter\u00E1rn\u00ED \u00FAdaje mapuj\u00EDc\u00ED danou t\u00E9matiku v klinick\u00E9 praxi prakticky neexistuj\u00ED."@cs . . . "14110" . "Stimulation of Prefrontal Cortex and Therapy of Negative Symptoms of Schizophrenia"@en . "1212-0383" . . . . "Ka\u0161p\u00E1rek, Tom\u00E1\u0161" . . "\u010Cesk\u00E1 a Slovensk\u00E1 psychiatrie" . . "Pal\u010D\u00EDkov\u00E1, Ivana" . . "frontal cortex; treatment; negative symptoms; rTMS; schizophrenia; stimulation"@en . . "Stimulace prefront\u00E1ln\u00EDho kortexu a l\u00E9\u010Dba negativn\u00EDch p\u0159\u00EDznak\u016F schizofrenie"@cs . . . "Negative symptoms are regarded as the most persistent and disabling component of schizophrenia. The possibility of influencing them by means of antipsychotics remains problematic. Repetitive transcranial magnetic simulation (rTMS) presents a new opportunity for influencing negative schizophrenic symptoms. A theoretical justification of the effect of rTMS on negative schizophrenic symptoms can be seen in the fact that high-frequency rTMS has an activating impact on cortex neurons. The negative correlation between activity of the frontal cortex and severity of negative symptoms has been proved repeatedly. Another important fact is that dopamine can be released in the mesolimbic and mesostriatal brain systems by high-frequency stimulation of the frontal cortex. There are hardly any consistent published data mapping the subject in clinical practice."@en . . "P(NR7986), Z(MSM0021622404)" . "\u010Ce\u0161kov\u00E1, Eva" . . . "6"^^ . "Stimulace prefront\u00E1ln\u00EDho kortexu a l\u00E9\u010Dba negativn\u00EDch p\u0159\u00EDznak\u016F schizofrenie" . "Stimulation of Prefrontal Cortex and Therapy of Negative Symptoms of Schizophrenia"@en . . "P\u0159ikryl, Radovan" . . "Ustohal, Libor" . "8" . "Stimulace prefront\u00E1ln\u00EDho kortexu a l\u00E9\u010Dba negativn\u00EDch p\u0159\u00EDznak\u016F schizofrenie"@cs . "6"^^ . "RIV/00216224:14110/06:00017937!RIV10-MZ0-14110___" . "2006" . . . "[B4D06ADB5150]" .