. . . "Koc\u00E1kov\u00E1, Ilona" . . "Jech, Z." . "[0D9B6E6394B6]" . . "Srovnal, Josef" . "Hoch, Ji\u0159\u00ED" . "Pilotn\u00ED studie identifikace prognostick\u00FDch marker\u016F u pacient\u016F s kolorekt\u00E1ln\u00EDm karcinomem anal\u00FDzou profil\u016F genov\u00E9 exprese."@cs . "Svoboda, Marek" . . . . "8"^^ . . . "Pilotn\u00ED studie identifikace prognostick\u00FDch marker\u016F u pacient\u016F s kolorekt\u00E1ln\u00EDm karcinomem anal\u00FDzou profil\u016F genov\u00E9 exprese."@cs . . "Kolorekt\u00E1ln\u00ED karcinom je jedn\u00EDm z nej\u010Dast\u011Bji se vyskytuj\u00EDc\u00EDch n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED. Nane\u0161t\u011Bst\u00ED v\u00FDznamn\u00E1 \u010D\u00E1st pacient\u016F v klinick\u00FDch st\u00E1di\u00EDch II a III um\u00EDr\u00E1 do p\u011Bti let po radik\u00E1ln\u00EDm chirurgick\u00E9m z\u00E1kroku n\u00E1sledkem progrese onemocn\u011Bn\u00ED. Racion\u00E1ln\u00ED p\u0159istup k indikaci adjuvantn\u00ED l\u00E9\u010Dby pro tyto pacienty nab\u00EDz\u00ED molekul\u00E1rn\u00ED charakterizace jejich rizikov\u00E9 podskupiny nap\u0159\u00ED\u010D ob\u011Bma klinick\u00FDmi st\u00E1dii pomoc\u00ED technologie DNA \u010Dip\u016F. Do studie byly za\u0159azeny bioptick\u00E9 vzorky dvan\u00E1cti pacient\u016F s histologicky potvrzen\u00FDm kolorekt\u00E1ln\u00EDm karcinomem (KRK) v klinick\u00E9m st\u00E1diu II a III tvo\u0159en\u00E9 minim\u00E1ln\u011B ze 70% malign\u00EDmi bu\u0148kami. \u0160est pacient\u016F m\u011Blo dobrou progn\u00F3zu s d\u00E9lkou bezp\u0159\u00EDznakov\u00E9ho p\u0159e\u017Eit\u00ED (DFS) del\u0161\u00ED ne\u017E 36 m\u011Bs\u00EDc\u016F, \u0161est m\u011Blo \u0161patnou progn\u00F3zu s DFS krat\u0161\u00EDm ne\u017E 36 m\u011Bs\u00EDc\u016F. Pomoc\u00ED n\u00EDzkohustotn\u00EDch oligonukleotidov\u00FDch makro\u010Dip\u016F spole\u010Dnosti SuperArray ur\u010Den\u00FDch k relativn\u00ED kvantifikaci exprese 128 gen\u016F potenci\u00E1ln\u011B zapojen\u00FDch do procesu metastazov\u00E1n\u00ED byly identifikov\u00E1ny profily genov\u00E9 exprese prim\u00E1rn\u00EDch KRK v\u0161ech 12 pacient\u016F."@cs . "2006" . . "P(NR9076), S, Z(MSM6198959216)" . "0862-495X" . "11"^^ . "Vyzula, Rostislav" . "olorectal cancer; DNA microarray technology; gene expression profiles; pathogenesis; prognosis"@en . . "Colorectal cancer (CRC) is one of the most common malignancies. Unfortunately a significant proportion of surgically cured patients in the early stage of the disease develop progression and die from the disease. Twelve patients who had histologically confirmed left-sided colon adenocarcinoma with a volume fraction showing at least 70% of malignant tumor cells were included. Only stage II-III patients according to IUCC with no prior chemotherapy or radiotherapy were eligible for the study. Six patients were poor prognosis cases with disease free survival (DFS) lower then 36 month and six were good prognosis cases with DFS>36 month. Relative gene expression levels of 128 genes potentially involved in cancer progression and dissemination were obtained by low-density oligonucleotide microarrays (SuperArray Bioscience Corp., Bethesda, MD) from 12 primary colon cancer samples."@en . . "RIV/00216224:14110/06:00017453!RIV10-MZ0-14110___" . . . . . "RIV/00216224:14110/06:00017453" . "Suppl." . "Garajov\u00E1, Ingrid" . "Identification of colorectal cancer prognostic markers by gene expression profiles analysis: pilot study"@en . "14110" . . "Slab\u00FD, Ond\u0159ej" . "Pilotn\u00ED studie identifikace prognostick\u00FDch marker\u016F u pacient\u016F s kolorekt\u00E1ln\u00EDm karcinomem anal\u00FDzou profil\u016F genov\u00E9 exprese." . . . . "Identification of colorectal cancer prognostic markers by gene expression profiles analysis: pilot study"@en . "Kolorekt\u00E1ln\u00ED karcinom je jedn\u00EDm z nej\u010Dast\u011Bji se vyskytuj\u00EDc\u00EDch n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED. Nane\u0161t\u011Bst\u00ED v\u00FDznamn\u00E1 \u010D\u00E1st pacient\u016F v klinick\u00FDch st\u00E1di\u00EDch II a III um\u00EDr\u00E1 do p\u011Bti let po radik\u00E1ln\u00EDm chirurgick\u00E9m z\u00E1kroku n\u00E1sledkem progrese onemocn\u011Bn\u00ED. Racion\u00E1ln\u00ED p\u0159istup k indikaci adjuvantn\u00ED l\u00E9\u010Dby pro tyto pacienty nab\u00EDz\u00ED molekul\u00E1rn\u00ED charakterizace jejich rizikov\u00E9 podskupiny nap\u0159\u00ED\u010D ob\u011Bma klinick\u00FDmi st\u00E1dii pomoc\u00ED technologie DNA \u010Dip\u016F. Do studie byly za\u0159azeny bioptick\u00E9 vzorky dvan\u00E1cti pacient\u016F s histologicky potvrzen\u00FDm kolorekt\u00E1ln\u00EDm karcinomem (KRK) v klinick\u00E9m st\u00E1diu II a III tvo\u0159en\u00E9 minim\u00E1ln\u011B ze 70% malign\u00EDmi bu\u0148kami. \u0160est pacient\u016F m\u011Blo dobrou progn\u00F3zu s d\u00E9lkou bezp\u0159\u00EDznakov\u00E9ho p\u0159e\u017Eit\u00ED (DFS) del\u0161\u00ED ne\u017E 36 m\u011Bs\u00EDc\u016F, \u0161est m\u011Blo \u0161patnou progn\u00F3zu s DFS krat\u0161\u00EDm ne\u017E 36 m\u011Bs\u00EDc\u016F. Pomoc\u00ED n\u00EDzkohustotn\u00EDch oligonukleotidov\u00FDch makro\u010Dip\u016F spole\u010Dnosti SuperArray ur\u010Den\u00FDch k relativn\u00ED kvantifikaci exprese 128 gen\u016F potenci\u00E1ln\u011B zapojen\u00FDch do procesu metastazov\u00E1n\u00ED byly identifikov\u00E1ny profily genov\u00E9 exprese prim\u00E1rn\u00EDch KRK v\u0161ech 12 pacient\u016F." . "Svoboda, Miroslav" . . . "Pilotn\u00ED studie identifikace prognostick\u00FDch marker\u016F u pacient\u016F s kolorekt\u00E1ln\u00EDm karcinomem anal\u00FDzou profil\u016F genov\u00E9 exprese." . . "\u0160efr, Roman" . "Fabian, Pavel" . "6"^^ . . "Klinick\u00E1 onkologie" . "492144" . "CZ - \u010Cesk\u00E1 republika" . .