"Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats."@en . . . . "Dost\u00E1lek, Miroslav" . "Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats." . "521489" . "RIV/00216224:14110/05:00014064!RIV10-MSM-14110___" . . "Tomandl, Josef" . "Hanesov\u00E1, Mariana" . "\u0160ulcov\u00E1, Alexandra" . "30" . "Methamphetamine is the fourth most frequently cited drug of abuse on treatment centre admission records behind cocaine, heroin and marijuana. We investigated the effect of methamphetamine (10 mg/kg, i.p., once daily for six days) on the pharmacokinetics of midazolam a substrate for rat cytochrome P-450 3A. Animals received a single injection of midazolam (5 mg/kg) in tail vein 24 h after the last dose of methamphetamine and placebo. Validated HPLC method was used to quantify all compounds of interest. The elimination half-life (t1/2) and the area under the concentration-time curve of midazolam were significantly reduced by pretreatment with methamphetamine to 63.8 % and 66.3 of control value, respectively and the clearance of midazolam was significantly increased by methamphetamine pretreatment. The results showed that administration of methamphetamine significantly stimulated metabolic activity of CYP3A1/2." . . "Eur J Drug Metab Pharmacokinet" . . "7"^^ . "Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats." . "Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats."@en . "CZ - \u010Cesk\u00E1 republika" . . . . "McCaskey Hada\u0161ov\u00E1, Eva" . . . "Z(MSM 141100001)" . "Methamphetamine is the fourth most frequently cited drug of abuse on treatment centre admission records behind cocaine, heroin and marijuana. We investigated the effect of methamphetamine (10 mg/kg, i.p., once daily for six days) on the pharmacokinetics of midazolam a substrate for rat cytochrome P-450 3A. Animals received a single injection of midazolam (5 mg/kg) in tail vein 24 h after the last dose of methamphetamine and placebo. Validated HPLC method was used to quantify all compounds of interest. The elimination half-life (t1/2) and the area under the concentration-time curve of midazolam were significantly reduced by pretreatment with methamphetamine to 63.8 % and 66.3 of control value, respectively and the clearance of midazolam was significantly increased by methamphetamine pretreatment. The results showed that administration of methamphetamine significantly stimulated metabolic activity of CYP3A1/2."@en . "7"^^ . "14110" . "Pistov\u010D\u00E1kov\u00E1, Jana" . "Linhart, Igor" . "RIV/00216224:14110/05:00014064" . . . . . . "[69AD2DD1C0EF]" . . "Midazolam; Methamphetamine; Cytochrome P-450; CYP3A1/2 isozyme"@en . . . . "8"^^ . "3" . . "000232621200008" . "0378-7966" . . "Ju\u0159ica, Jan" .