"CZ - \u010Cesk\u00E1 republika" . . . "RIV/00216224:14110/05:00014064!RIV08-MSM-14110___" . . "0378-7966" . "Eur J Drug Metab Pharmacokinet" . . "Vliv metamfetaminu na farmakokinetiku dextrometorfanu a midazolamu."@cs . "7"^^ . "Z(MSM 141100001)" . "\u0160ulcov\u00E1, Alexandra" . . "Linhart, Igor" . . "Vliv metamfetaminu na farmakokinetiku dextrometorfanu a midazolamu."@cs . "Methamphetamine is the fourth most frequently cited drug of abuse on treatment centre admission records behind cocaine, heroin and marijuana. We investigated the effect of methamphetamine (10 mg/kg, i.p., once daily for six days) on the pharmacokinetics of midazolam a substrate for rat cytochrome P-450 3A. Animals received a single injection of midazolam (5 mg/kg) in tail vein 24 h after the last dose of methamphetamine and placebo. Validated HPLC method was used to quantify all compounds of interest. The elimination half-life (t1/2) and the area under the concentration-time curve of midazolam were significantly reduced by pretreatment with methamphetamine to 63.8 % and 66.3 of control value, respectively and the clearance of midazolam was significantly increased by methamphetamine pretreatment. The results showed that administration of methamphetamine significantly stimulated metabolic activity of CYP3A1/2. With regard to a high level of homology between human and rat CYP isoforms studied, the result" . . . . . . . . "[6694D531583D]" . "3" . "8"^^ . "Effect of methamphetamine on pharmacokinetics of dextromethorphan and midazolam." . "Midazolam; Methamphetamine; Cytochrome P-450; CYP3A1/2 isozyme"@en . "Effect of methamphetamine on pharmacokinetics of dextromethorphan and midazolam." . "McCaskey Hada\u0161ov\u00E1, Eva" . "195-201" . . "7"^^ . "14110" . . "519363" . . . . "Methamphetamine is the fourth most frequently cited drug of abuse on treatment centre admission records behind cocaine, heroin and marijuana. We investigated the effect of methamphetamine (10 mg/kg, i.p., once daily for six days) on the pharmacokinetics of midazolam a substrate for rat cytochrome P-450 3A. Animals received a single injection of midazolam (5 mg/kg) in tail vein 24 h after the last dose of methamphetamine and placebo. Validated HPLC method was used to quantify all compounds of interest. The elimination half-life (t1/2) and the area under the concentration-time curve of midazolam were significantly reduced by pretreatment with methamphetamine to 63.8 % and 66.3 of control value, respectively and the clearance of midazolam was significantly increased by methamphetamine pretreatment. The results showed that administration of methamphetamine significantly stimulated metabolic activity of CYP3A1/2. With regard to a high level of homology between human and rat CYP isoforms studied, the result"@en . "Effect of methamphetamine on pharmacokinetics of dextromethorphan and midazolam."@en . . "Ju\u0159ica, Jan" . . "Dost\u00E1lek, Miroslav" . "Hanesov\u00E1, Mariana" . "Effect of methamphetamine on pharmacokinetics of dextromethorphan and midazolam."@en . "Pistov\u010D\u00E1kov\u00E1, Jana" . "C\u00EDlem studie bylo popsat vliv opakovan\u00E9ho pod\u00E1v\u00E1n\u00ED metamfetaminu (10 mg/ kg, i.p., jednou denn\u011B po dobu 6ti dn\u016F) na farmakokinetick\u00E9 parametry dextrometorfanu (markeru metabolick\u00E9 aktivity CYP2D2) a midazolamu (markeru metabolick\u00E9 aktivity CYP3A1/2). Polo\u010Das eliminace midazolamu a plocha pod koncentra\u010Dn\u00ED k\u0159ivkou midazolamu byly opakovan\u00FDm pod\u00E1v\u00E1n\u00EDm metamfetaminu statisticky v\u00FDznamn\u011B zkr\u00E1ceny na 63.8 % resp. 66.3 % hodnoty kontroln\u00ED skupiny. Clearance midazolamu byla metamfetaminem statisticky v\u00FDznamn\u011B zv\u00FD\u0161ena. Metamfetamin statisticky v\u00FDznamn\u011B zv\u00FD\u0161il aktivitu formy CYP3A1/2 a d\u00EDky velk\u00E9 podobnosti potkan\u00ED a lidsk\u00E9 formy se zjist\u011Bn\u00E9 v\u00FDsledky mohou st\u00E1t v\u00FDznamn\u00E9 pro klinickou praxi."@cs . "Tomandl, Josef" . . "RIV/00216224:14110/05:00014064" . "30" . .