"Bu\u010Dkov\u00E1, Dana" . "2005-01-01+01:00"^^ . "1562-3629" . . "International Journal on Immunorehabilitation" . . "14110" . "A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy"@en . "Athens, Greece" . . "A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy"@en . "74-74" . "Atopy is a generally considered to be caused by interaction of genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for atopy, as it is localized on chromosome 5q31.1, a region that has been linked to asthma and atopic responses. We investigated relationship among atopic phenotypes and the 1341G/T polymorphism in exon of the CD14 gene in the Czech population. Polymerase chain reaction with RFLP analyses were used to determine the CD14 genotypes in subjects with IgE-mediated allergic diseases (n = 290) and random controls (n = 189). IgE-mediated allergy was recognised by specific IgE or a positive skin prick test to any one or more allergens. The CD14 allele or genotype distributions were similar in patients and control group. However, when atopic patients were subdivided in subjects with positive and those with negative skin prick tests, this polymorphism was significantly associated with a positive reactivity to the mites. T allele of the 1341G/T polymorphism were"@en . . . "A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy" . "1"^^ . "RIV/00216224:14110/05:00012716" . "Izakovi\u010Dov\u00E1-Holl\u00E1, Lydie" . "511026" . . . . "Polymorfizmus v exonu genu pro CD14 receptor u mlad\u00FDch atopick\u00FDch pacient\u016F v \u010Desk\u00E9 populaci"@cs . . "P(GP310/03/D193)" . "[26FD4878BE49]" . "Atopy is a generally considered to be caused by interaction of genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for atopy, as it is localized on chromosome 5q31.1, a region that has been linked to asthma and atopic responses. We investigated relationship among atopic phenotypes and the 1341G/T polymorphism in exon of the CD14 gene in the Czech population. Polymerase chain reaction with RFLP analyses were used to determine the CD14 genotypes in subjects with IgE-mediated allergic diseases (n = 290) and random controls (n = 189). IgE-mediated allergy was recognised by specific IgE or a positive skin prick test to any one or more allergens. The CD14 allele or genotype distributions were similar in patients and control group. However, when atopic patients were subdivided in subjects with positive and those with negative skin prick tests, this polymorphism was significantly associated with a positive reactivity to the mites. T allele of the 1341G/T polymorphism were" . "RIV/00216224:14110/05:00012716!RIV06-GA0-14110___" . "CD14; gene; polymorphism; IgE; allergy"@en . . "3"^^ . "Znojil, Vladim\u00EDr" . "3"^^ . "Polymorfizmus v exonu genu pro CD14 receptor u mlad\u00FDch atopick\u00FDch pacient\u016F v \u010Desk\u00E9 populaci"@cs . "Gen k\u00F3duj\u00EDc\u00ED CD14 receptor je kandid\u00E1tn\u00EDm genem pro atopii vzhledem ke sv\u00E9 poloze na chromozomu 5q. V t\u00E9to studii byla nalezena asociace 1341G/T polymorfizmu v CD14 genu s atopick\u00FDm fenotypem v \u010Desk\u00E9 populaci."@cs . . "III European Asthma Congress" . . . . . . "Moscow, Russia" . . . . . "A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy" .