. . "0862-495X" . . "5"^^ . . "7"^^ . "METALLOTHIONEIN AS A PROGNOSTIC MARKER OF TUMOR DISEASE"@en . "METALLOTHIONEIN AS A PROGNOSTIC MARKER OF TUMOR DISEASE"@en . "Pot\u011B\u0161il, David" . . "Metalothionein jako prognostick\u00FD marker n\u00E1dorov\u00E9ho onemocn\u011Bn\u00ED" . "RIV/00216224:14110/04:00020425" . "P(GP525/04/P132)" . . "[0249652711CA]" . "\u010Cumov\u00E1, Jana" . . "diagnostics; human tumors; metallothionein; overexpression; prognostic marker"@en . "Metalothionein jako prognostick\u00FD marker n\u00E1dorov\u00E9ho onemocn\u011Bn\u00ED" . "Metalothionein (MT) je n\u00EDzkomolekul\u00E1rn\u00ED intracelul\u00E1rn\u00ED protein, jeho\u017E prim\u00E1rn\u00ED funkc\u00ED je udr\u017Een\u00ED homeost\u00E1zy t\u011Bk\u00FDch kov\u016F v \u017Eiv\u00FDch organismech. O molekul\u00E1rn\u00EDch mechanismech exprese MT je zn\u00E1mo velmi m\u00E1lo. Regulace exprese se pravd\u011Bpodobn\u011B \u00FA\u010Dastn\u00ED samotn\u00FD kov vazbou na transkrip\u010Dn\u00ED faktor MTF-1. Synt\u00E9za lidsk\u00E9ho metalothioneinu (MT-1a, MT-2a) m\u016F\u017Ee b\u00FDt indukov\u00E1na vzr\u016Fstaj\u00EDc\u00ED koncentrac\u00ED t\u011B\u017Ek\u00FDch kov\u016F, hormon\u016F, cytokin\u016F nebo xenobiotik. Ned\u00E1vn\u00E9 v\u00FDzkumy ukazuj\u00ED na v\u00FDznamn\u00FD vztah koncentrace MT ke karcinogenezi, spont\u00E1nn\u00ED mutagenezi a \u00FA\u010Dinnosti protin\u00E1dorov\u00FDch l\u00E9\u010Div. Overexprese metalothionein\u016F je studov\u00E1na jako nov\u00FD prognostick\u00FD marker u \u0159ady malign\u00EDch a gradingovan\u00FDch n\u00E1dor\u016F."@cs . . "17/2004" . "Vacek, Jan" . "CZ - \u010Cesk\u00E1 republika" . "Pr\u016F\u0161a, Richard" . . . . "Hradeck\u00FD, Jan" . "Klinick\u00E1 onkologie" . . . "RIV/00216224:14110/04:00020425!RIV09-GA0-14110___" . "14110" . "Metalothionein jako prognostick\u00FD marker n\u00E1dorov\u00E9ho onemocn\u011Bn\u00ED"@cs . . . . . "573055" . . . . "6"^^ . "Kizek, Ren\u00E9" . "Metallothionein is a low-molecular intracellular protein which can play an important role in heavy metal homeostasis in living organisms. Less is known about molecular mechanisms of MT expression. Metals probably participate in MT expression by binding to transcriptional factor MTF-1. Expression of human metallothioneins (MT-1a, MT-2a) can be induced by increasing amount of heavy metals, hormones, cytokines, and/or xenobiotics. Recent studies described the important relationship between MT and carcinogenesis, spontaneous mutagenesis and anti-cancer drugs. Overexpression of metallothioneins is studied as a new prognostic marker in a number of malignant and high grading tumors."@en . "Metalothionein (MT) je n\u00EDzkomolekul\u00E1rn\u00ED intracelul\u00E1rn\u00ED protein, jeho\u017E prim\u00E1rn\u00ED funkc\u00ED je udr\u017Een\u00ED homeost\u00E1zy t\u011Bk\u00FDch kov\u016F v \u017Eiv\u00FDch organismech. O molekul\u00E1rn\u00EDch mechanismech exprese MT je zn\u00E1mo velmi m\u00E1lo. Regulace exprese se pravd\u011Bpodobn\u011B \u00FA\u010Dastn\u00ED samotn\u00FD kov vazbou na transkrip\u010Dn\u00ED faktor MTF-1. Synt\u00E9za lidsk\u00E9ho metalothioneinu (MT-1a, MT-2a) m\u016F\u017Ee b\u00FDt indukov\u00E1na vzr\u016Fstaj\u00EDc\u00ED koncentrac\u00ED t\u011B\u017Ek\u00FDch kov\u016F, hormon\u016F, cytokin\u016F nebo xenobiotik. Ned\u00E1vn\u00E9 v\u00FDzkumy ukazuj\u00ED na v\u00FDznamn\u00FD vztah koncentrace MT ke karcinogenezi, spont\u00E1nn\u00ED mutagenezi a \u00FA\u010Dinnosti protin\u00E1dorov\u00FDch l\u00E9\u010Div. Overexprese metalothionein\u016F je studov\u00E1na jako nov\u00FD prognostick\u00FD marker u \u0159ady malign\u00EDch a gradingovan\u00FDch n\u00E1dor\u016F." . . "Metalothionein jako prognostick\u00FD marker n\u00E1dorov\u00E9ho onemocn\u011Bn\u00ED"@cs . "6" . "Adam, Vojt\u011Bch" .