"9"^^ . . "3"^^ . "Christ\u00E9, Georges" . . "P(GP204/02/D129), Z(AV0Z2076919), Z(MSM 141100004)" . "568976" . . "Ionic concentration changes in the tubular system of rat ventricular cardiac cell model" . . "Iontov\u011B-koncetra\u010Dn\u00ED zm\u011Bny v tubul\u00E1rn\u00EDm syst\u00E9mu modelu komorov\u00E9 bu\u0148ky potkana"@cs . . "Ionic concentration changes in the tubular system of rat ventricular cardiac cell model" . . "RIV/00216224:14110/04:00010869" . "[51235FBDD776]" . . . "We present a design of a model of rat ventricular cardiomyocyte with transverse-axial tubular system and the results of the first simulations of tubular ionic concentration changes at different stimulation rates. The morphology of tubular system and the distribution of ionic channels in tubular membrane were described to meet the recent data of Soeller and Cannell (1999) and of Orchard's group in Leeds. Exploration of activity-dependent changes in tubular ionic concentrations revealed an increase in relative Ca2+ depletion from 7.3 % to 14 % when increasing the stimulation frequency from 1 Hz to 5 Hz. Meanwhile, relative K+ accumulation decreased from 4.3 % to 3 %. These effects led to a limitation of intracellular Ca2+ overload." . . "Ionic concentration changes in the tubular system of rat ventricular cardiac cell model"@en . "1-9" . "80-85918-88-9" . . "Pr\u00E1ce prezentuje sestaven\u00ED matematick\u00E9ho modelu komorov\u00E9 bu\u0148ky laboratorn\u00EDho potkana se zahrnut\u00FDm popisem funkce transverz\u00E1ln\u011B - axi\u00E1ln\u00EDho tubul\u00E1rn\u00EDho syst\u00E9mu a p\u0159edstavuje v\u00FDsledky simulac\u00ED odhaluj\u00EDc\u00ED velikost iontov\u011B-koncentra\u010Dn\u00EDch zm\u011Bn uvnit\u0159 tubul\u00E1rn\u00EDho syst\u00E9mu potkana."@cs . "14110" . . . . . . "We present a design of a model of rat ventricular cardiomyocyte with transverse-axial tubular system and the results of the first simulations of tubular ionic concentration changes at different stimulation rates. The morphology of tubular system and the distribution of ionic channels in tubular membrane were described to meet the recent data of Soeller and Cannell (1999) and of Orchard's group in Leeds. Exploration of activity-dependent changes in tubular ionic concentrations revealed an increase in relative Ca2+ depletion from 7.3 % to 14 % when increasing the stimulation frequency from 1 Hz to 5 Hz. Meanwhile, relative K+ accumulation decreased from 4.3 % to 3 %. These effects led to a limitation of intracellular Ca2+ overload."@en . . . "P\u00E1sek, Michal" . "\u0160imurda, Ji\u0159\u00ED" . "RIV/00216224:14110/04:00010869!RIV08-AV0-14110___" . "Svratka" . "Engineering Mechanics 2004" . "Svratka" . . "Iontov\u011B-koncetra\u010Dn\u00ED zm\u011Bny v tubul\u00E1rn\u00EDm syst\u00E9mu modelu komorov\u00E9 bu\u0148ky potkana"@cs . "Ionic concentration changes in the tubular system of rat ventricular cardiac cell model"@en . . "\u00DAstav termomechaniky AV \u010CR" . . "2004-05-10+02:00"^^ . "cardiac cell; tubular system; quantitative modelling"@en . "2"^^ .