"[851BB4CD895D]" . "54" . "Vplyv \u0161tandardizovan\u00E9ho extraktu LI160 (Hypericum perforatum) na leukocyt\u00E1rnu fagocyt\u00F3zu vo zvieracom modeli depresie"@cs . "Dost\u00E1lek, Miroslav" . "St. Johns wort is a herbal antidepressant with proven efficacy comparable to classical antidepressants with fewer side effects. However the effects of St. Johns wort extracts on the immune system function have not been extensively studied yet despite alterations of the immune system functions are known in depressed patients. In the present study we tested the effect of LI 160 standardized herbal extract (analysis by coworkers 2,3) on leukocyte phagocytic activity in the rodent model of depression, the olfactory bulbectomized (OB) rat. The activity of leukocyte zymosan-induced phagocytosis was examined via measurement of chemiluminiscence potentiated by luminol. In LI 160 (100 mg/kg/day, 10 days i.p.) treated OB rats a significant (p<0.05) inhibition of the OB-related hyperactivity was observed. LI 160 did not produce any sedative effect on the locomotion of the sham-operated rats. Thus the present data confirm an antidepressant-like behavioural impact of LI 160 in the OB rat model of depression. Th"@en . "Sledovali jsme vliv LI160 na leukocyt\u00E1rn\u00ED fagocyt\u00F3zu v modelu olfaktorick\u00E9 bulbektomie, kter\u00FD se pou\u017E\u00EDva ke skr\u00EDningu antidepresivn\u00EDch \u00FA\u010Dink\u016F l\u00E1tek. Bulbektomie u potkan\u016F navozuje soubor charakteristick\u00FDch zm\u011Bn, kter\u00E9 selektivn\u011B reaguj\u00ED na chronick\u00E9 pod\u00E1v\u00E1n\u00ED antidepresiv. \u00DA\u010Dinnost LI160 jsme ov\u011B\u0159ili testem otev\u0159en\u00E9ho pole, z imunitn\u00EDch zm\u011Bn jsme hodnotili leukocyt\u00E1rn\u00ED fagocyt\u00F3zu, kter\u00E1 odr\u00E1\u017E\u00ED bun\u011B\u010Dnou imunitn\u00ED funkci. U potkan\u016F byla proveden\u00E1 ablace obou olfaktorick\u00FDch bulb\u016F. \u010Cichov\u00FD org\u00E1n kontroln\u00ED skupiny zv\u00ED\u0159at z\u016Fstal intaktn\u00ED. Zv\u00ED\u0159at\u016Fm byl 10 dn\u016F intraperitone\u00E1lne aplikovan\u00FD fyziologick\u00FD roztok (2 ml/kg/den) nebo standardizovan\u00FD extrakt LI160 z Hypericum perforatum (100 mg/kg/den). N\u00E1sledn\u011B byl proveden\u00FD 10-min z\u00E1znam lokomotorick\u00E9 aktivity a odb\u011Br krve na vy\u0161et\u0159en\u00ED leukocyt\u00E1rn\u00ED fagocyt\u00F3zy pomoc\u00ED chemiluminometrick\u00E9 metody. LI160 inhiboval hyperlokomoci navozenou bulbektomi\u00ED, a to bez ovlyvn\u011Bn\u00ED motoriky kontroln\u00EDch potkan\u016F, co sv\u011Bd\u010D\u00ED pro antidepresivn\u00ED \u00FA\u010Dinek v pou\u017Eit\u00E9m modelu deprese. U bulbektom" . "1"^^ . . "2004-01-01+01:00"^^ . "Effect of LI160 on leukocyte phagocytosis in an animal model of depression"@en . "Linhart, Igor" . . "Effect of LI160 on leukocyte phagocytosis in an animal model of depression"@en . "FN u sv. Anny, LF MU" . . "Sledovali jsme vliv LI160 na leukocyt\u00E1rn\u00ED fagocyt\u00F3zu v modelu olfaktorick\u00E9 bulbektomie, kter\u00FD se pou\u017E\u00EDva ke skr\u00EDningu antidepresivn\u00EDch \u00FA\u010Dink\u016F l\u00E1tek. Bulbektomie u potkan\u016F navozuje soubor charakteristick\u00FDch zm\u011Bn, kter\u00E9 selektivn\u011B reaguj\u00ED na chronick\u00E9 pod\u00E1v\u00E1n\u00ED antidepresiv. \u00DA\u010Dinnost LI160 jsme ov\u011B\u0159ili testem otev\u0159en\u00E9ho pole, z imunitn\u00EDch zm\u011Bn jsme hodnotili leukocyt\u00E1rn\u00ED fagocyt\u00F3zu, kter\u00E1 odr\u00E1\u017E\u00ED bun\u011B\u010Dnou imunitn\u00ED funkci. U potkan\u016F byla proveden\u00E1 ablace obou olfaktorick\u00FDch bulb\u016F. \u010Cichov\u00FD org\u00E1n kontroln\u00ED skupiny zv\u00ED\u0159at z\u016Fstal intaktn\u00ED. Zv\u00ED\u0159at\u016Fm byl 10 dn\u016F intraperitone\u00E1lne aplikovan\u00FD fyziologick\u00FD roztok (2 ml/kg/den) nebo standardizovan\u00FD extrakt LI160 z Hypericum perforatum (100 mg/kg/den). N\u00E1sledn\u011B byl proveden\u00FD 10-min z\u00E1znam lokomotorick\u00E9 aktivity a odb\u011Br krve na vy\u0161et\u0159en\u00ED leukocyt\u00E1rn\u00ED fagocyt\u00F3zy pomoc\u00ED chemiluminometrick\u00E9 metody. LI160 inhiboval hyperlokomoci navozenou bulbektomi\u00ED, a to bez ovlyvn\u011Bn\u00ED motoriky kontroln\u00EDch potkan\u016F, co sv\u011Bd\u010D\u00ED pro antidepresivn\u00ED \u00FA\u010Dinek v pou\u017Eit\u00E9m modelu deprese. U bulbektom"@cs . . "Vplyv \u0161tandardizovan\u00E9ho extraktu LI160 (Hypericum perforatum) na leukocyt\u00E1rnu fagocyt\u00F3zu vo zvieracom modeli depresie" . "Tomandl, Josef" . . . "Ju\u0159ica, Jan" . "Vplyv \u0161tandardizovan\u00E9ho extraktu LI160 (Hypericum perforatum) na leukocyt\u00E1rnu fagocyt\u00F3zu vo zvieracom modeli depresie"@cs . "Vplyv \u0161tandardizovan\u00E9ho extraktu LI160 (Hypericum perforatum) na leukocyt\u00E1rnu fagocyt\u00F3zu vo zvieracom modeli depresie" . . . . "Pistov\u010D\u00E1kov\u00E1, Jana" . . "Sborn\u00EDk abstrakt XI. ro\u010Dn\u00EDka Konference mlad\u00FDch l\u00E9ka\u0159\u016F" . "RIV/00216224:14110/04:00010523" . . . . . . "593318" . "depression; hypericum perforatum; immune system olfactory bulbectomy; rat"@en . . . "RIV/00216224:14110/04:00010523!RIV08-MSM-14110___" . "Z(MSM 141100001)" . "McCaskey Hada\u0161ov\u00E1, Eva" . "Brno" . . "6"^^ . "Brno" . "14110" . "7"^^ . . . . "\u0160ulcov\u00E1, Alexandra" . .