. "14-15" . "2004-01-01+01:00"^^ . "2"^^ . "RIV/00216224:14110/04:00010021" . "Effect of St Johns wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver" . . . "2"^^ . . . "Masarykova univerzita v Brn\u011B. L\u00E9ka\u0159sk\u00E1 fakulta" . "Brno" . "562026" . "1"^^ . "Brno" . . "Effect of St Johns wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver"@en . "Dost\u00E1lek, Miroslav" . "Vliv standardizovan\u00E9ho extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu vybran\u00FDch izoforem cytochromu P450 v preklinick\u00E9m experimentu"@cs . . . "[4546DC166BEE]" . "St. Johns wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and a herbal antidepressant that has been implicated in drug interactions with substrates of several cytochrome P450 (CYP) isozymes. Drug interactions linked to the use of St. Johns wort are now surfacing in the scientific literature. A clinical trial showed that co-administration of St. Johns wort extracts with digoxin resulted in significantly decreased drug plasma levels. Studies in healthy individuals and patients found that St. Johns wort preparations reduced significantly plasma levels of indinavir, nevirapine, cyclosporine, theophylline, midazolam, simvastatin, ethinyestradiol, warfarin and phenprocoumon, amitriptyline and nortriptyline. The aim of our study was to ascertain the influence of standardized extract LI 160 - 100 mg/kg, i.p., once daily for 10 days - (containing 280 g of hypericin, 300 g of pseudohypericin, 6.5 mg of hyperforin and 10 mg of hyperosid in the single dose of 100 mg/kg) on metabolic a"@en . "program a abstrakta" . . . "RIV/00216224:14110/04:00010021!RIV08-MSM-14110___" . "14110" . "Pistov\u010D\u00E1kov\u00E1, Jana" . . "izolated perfused liver; Hypericum perforatum; CYP450"@en . . "Effect of St Johns wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver"@en . "Vliv standardizovan\u00E9ho extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu vybran\u00FDch izoforem cytochromu P450 v preklinick\u00E9m experimentu"@cs . . "St. Johns wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and a herbal antidepressant that has been implicated in drug interactions with substrates of several cytochrome P450 (CYP) isozymes. Drug interactions linked to the use of St. Johns wort are now surfacing in the scientific literature. A clinical trial showed that co-administration of St. Johns wort extracts with digoxin resulted in significantly decreased drug plasma levels. Studies in healthy individuals and patients found that St. Johns wort preparations reduced significantly plasma levels of indinavir, nevirapine, cyclosporine, theophylline, midazolam, simvastatin, ethinyestradiol, warfarin and phenprocoumon, amitriptyline and nortriptyline. The aim of our study was to ascertain the influence of standardized extract LI 160 - 100 mg/kg, i.p., once daily for 10 days - (containing 280 g of hypericin, 300 g of pseudohypericin, 6.5 mg of hyperforin and 10 mg of hyperosid in the single dose of 100 mg/kg) on metabolic a" . "Z(MSM 141100001)" . . . "Effect of St Johns wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver" . "T\u0159ezalka te\u010Dkovan\u00E1 (Hypericum perforatum) je sou\u010D\u00E1st\u00ED voln\u011B prodejn\u00FDch potravn\u00EDch dopl\u0148k\u016F a s \u00FAsp\u011Bchem se pou\u017E\u00EDv\u00EDv\u00E1 jako p\u0159\u00EDrodn\u00ED antidepresivum, byly u n\u00ED v\u0161ak referov\u00E1ny \u010Detn\u00E9 interakce se subtr\u00E1ty enzymatick\u00E9ho syst\u00E9mu cytochromu P-450. Interakce l\u00E1tek a t\u0159ezalky te\u010Dkovan\u00E9 jsou hojn\u011B diskutovan\u00FDm probl\u00E9mem v odborn\u00E9 literatu\u0159e. Klinick\u00E9 studiu poukazuj\u00ED na skute\u010Dnost, \u017Ee extrakt t\u0159ezalky te\u010Dkovan\u00E9 v\u00FDznamn\u011B sni\u017Euje plazmatickou hladinu digoxinu. Studie proveden\u00E9 se zdrav\u00FDmi dobrovoln\u00EDky i pacienty s depresivn\u00ED poruchou referuj\u00ED o sni\u017Eov\u00E1n\u00ED plazmatick\u00FDch hladin i dal\u0161\u00EDch l\u00E9\u010Div - jsou to indinavir, nevirapin, cyklosporin, teofylin, midazolam, simvastatin, ethinyestradiol, warfarin, amitriptylin a nortriptylin. C\u00EDlem p\u0159edkl\u00E1dan\u00E9 studie bylo popsat vliv standardizovan\u00E9ho extraktu LI 160 - 100 mg/kg, i.p., jednou denn\u011B po dobu 10ti dn\u016F - (obsahuj\u00EDc\u00ED v jedn\u00E9 d\u00E1vce 280 g hypericinu, 300 g pseudohypericinu, 6.5 mg hyperforinu a 10 mg hyperosidu) na metabolickou aktivitu klinicky nejv\u00FDznamn\u011Bj\u0161\u00EDch izoenzym\u016F c"@cs . . .