"\u010Casopis l\u00E9ka\u0159\u016F \u010Desk\u00FDch" . "\u017Delezo je esenci\u00E1ln\u00ED prvek pro v\u0161echny \u017Eiv\u00E9 organizmy. Je sou\u010D\u00E1st\u00ED mnoha protein\u016F zast\u00E1vaj\u00EDc\u00EDch kl\u00ED\u010Dov\u00E9 funkce ve fyziologick\u00FDch procesech jako je transport kysl\u00EDku, respirace, synt\u00E9za DNA, regulace bun\u011B\u010Dn\u00E9ho cyklu a mnoh\u00E9 dal\u0161\u00ED. Voln\u00E9 \u017Eelezo je velmi reaktivn\u00ED a jeho nadbytek m\u016F\u017Ee v\u00E9st k po\u0161kozen\u00ED tk\u00E1n\u00ED a org\u00E1n\u016F. Proto\u017Ee neexistuje mechanizmus vylu\u010Dov\u00E1n\u00ED \u017Eeleza z t\u011Bla, je jeho absorpce ve st\u0159ev\u011B za fyziologick\u00FDch okolnost\u00ED p\u0159\u00EDsn\u011B regulov\u00E1na. Pokrok v metodologick\u00FDch p\u0159\u00EDstupech umo\u017Enil identifikaci mnoha gen\u016F a protein\u016F pod\u00EDlej\u00EDc\u00EDch se na absorpci \u017Eeleza a pochopen\u00ED z\u00E1kladn\u00EDch proces\u016F jeho p\u0159\u00EDjmu, transportu a skladov\u00E1n\u00ED na bun\u011B\u010Dn\u00E9 \u00FArovni. P\u0159esto v\u0161ak st\u00E1le nejsou n\u011Bkter\u00E9 pochody \u00FApln\u011B objasn\u011Bny. Mnoho nejasn\u00E9ho z\u016Fst\u00E1v\u00E1 hlavn\u011B v ot\u00E1zce regulace p\u0159\u00EDjmu \u017Eeleza v z\u00E1vislosti na pot\u0159eb\u00E1ch organizmu. Poruchy metabolizmu \u017Eeleza, jak ve smyslu jeho deficitu tak nadbytku, jsou pom\u011Brn\u011B \u010Dast\u00FDm onemocn\u011Bn\u00EDm. Rostouc\u00ED znalosti o fyziologick\u00E9m metabolizmu \u017Eeleza jsou rychle reflektov\u00E1ny pokroky v diagnostice, preven"@cs . . . . "RIV/00216224:14110/04:00009872!RIV08-MSM-14110___" . . "9" . "Nov\u011Bj\u0161\u00ED poznatky o metabolizmu \u017Eeleza a jeho poruch\u00E1ch"@cs . "Ka\u0148kov\u00E1, Kate\u0159ina" . "Nov\u011Bj\u0161\u00ED poznatky o metabolizmu \u017Eeleza a jeho poruch\u00E1ch" . "New lessons in the iron metabolism and its disorders"@en . . . . "[23F8D47042F4]" . "6"^^ . . . "0008-7335" . . "Iron is an essential element to all living organisms. It is a component of many proteins with important functions in physiological processes such as oxygen transport, respiration, DNA synthesis, cell cycle regulation and many others. Free iron is highly reactive and its excess can lead to tissue and organ damage. Intestinal absorption of iron is tightly regulated because there is no excretory mechanism for excessive iron. Improved methodology led to the identification of many genes and proteins involved in iron metabolism and to understanding of basic processes of iron intake, transport and storage. But some aspects still remain unclear - mainly regulation of iron intake according to the body needs. Disorders of iron metabolism, either deficiency or overload, are relatively common diseases. Growing understanding of physiologic iron metabolism is rapidly reflected in diagnistics, preventive screening and therapy of its disorders."@en . "RIV/00216224:14110/04:00009872" . . "P(GP303/02/D127), Z(MSM 141100002)" . . . "143" . . . . "iron; hemochromatosis; transferin; feritin; hepcidin; sideropenia; haptoglobin; hemoxygenas\u00EB; hemopexin; anemia"@en . "Nov\u011Bj\u0161\u00ED poznatky o metabolizmu \u017Eeleza a jeho poruch\u00E1ch" . . . . "1" . . . "P\u00E1cal, Luk\u00E1\u0161" . . "New lessons in the iron metabolism and its disorders"@en . "2"^^ . . "\u017Delezo je esenci\u00E1ln\u00ED prvek pro v\u0161echny \u017Eiv\u00E9 organizmy. Je sou\u010D\u00E1st\u00ED mnoha protein\u016F zast\u00E1vaj\u00EDc\u00EDch kl\u00ED\u010Dov\u00E9 funkce ve fyziologick\u00FDch procesech jako je transport kysl\u00EDku, respirace, synt\u00E9za DNA, regulace bun\u011B\u010Dn\u00E9ho cyklu a mnoh\u00E9 dal\u0161\u00ED. Voln\u00E9 \u017Eelezo je velmi reaktivn\u00ED a jeho nadbytek m\u016F\u017Ee v\u00E9st k po\u0161kozen\u00ED tk\u00E1n\u00ED a org\u00E1n\u016F. Proto\u017Ee neexistuje mechanizmus vylu\u010Dov\u00E1n\u00ED \u017Eeleza z t\u011Bla, je jeho absorpce ve st\u0159ev\u011B za fyziologick\u00FDch okolnost\u00ED p\u0159\u00EDsn\u011B regulov\u00E1na. Pokrok v metodologick\u00FDch p\u0159\u00EDstupech umo\u017Enil identifikaci mnoha gen\u016F a protein\u016F pod\u00EDlej\u00EDc\u00EDch se na absorpci \u017Eeleza a pochopen\u00ED z\u00E1kladn\u00EDch proces\u016F jeho p\u0159\u00EDjmu, transportu a skladov\u00E1n\u00ED na bun\u011B\u010Dn\u00E9 \u00FArovni. P\u0159esto v\u0161ak st\u00E1le nejsou n\u011Bkter\u00E9 pochody \u00FApln\u011B objasn\u011Bny. Mnoho nejasn\u00E9ho z\u016Fst\u00E1v\u00E1 hlavn\u011B v ot\u00E1zce regulace p\u0159\u00EDjmu \u017Eeleza v z\u00E1vislosti na pot\u0159eb\u00E1ch organizmu. Poruchy metabolizmu \u017Eeleza, jak ve smyslu jeho deficitu tak nadbytku, jsou pom\u011Brn\u011B \u010Dast\u00FDm onemocn\u011Bn\u00EDm. Rostouc\u00ED znalosti o fyziologick\u00E9m metabolizmu \u017Eeleza jsou rychle reflektov\u00E1ny pokroky v diagnostice, preven" . "14110" . "2"^^ . "576700" . . "Nov\u011Bj\u0161\u00ED poznatky o metabolizmu \u017Eeleza a jeho poruch\u00E1ch"@cs . . "CZ - \u010Cesk\u00E1 republika" .