. . . "Antidepressive-like felbamate effects on exploratory behaviour in mice" . "Pistov\u010D\u00E1kov\u00E1, Jana" . . "RIV/00216224:14110/03:00009515" . "[936C688CD3AD]" . "2"^^ . "598590" . "The antiepileptics of the 3rd generation are currently reported from clinics to show antidepressant effects. Therefore the study investigated one of them, felbamate for its potential anti-depressant activity in an animal model based on agonistic interactions of non-aggressive group-housed male mice with aggressive isolates. After the repeated agonistic interactions the group-housed mice exhibit depressed locomotor/exploratory behaviour in a novel open field arena, which can be disinhibited by clinically used antidepressants (Steinberg H, 1990). In our experiment the group-housed mice responded to felbamate at the doses 60 and 240 mg/kg orally by a significant (p < 0.05) disinhibiton of their suppresed locomotor/exploratory behaviour, thus felbamate produced an antidepresive-like effect, which is in correspondence with clinical reports on a potential antidepressant action of felbamate."@en . "1-2" . "The antiepileptics of the 3rd generation are currently reported from clinics to show antidepressant effects. Therefore the study investigated one of them, felbamate for its potential anti-depressant activity in an animal model based on agonistic interactions of non-aggressive group-housed male mice with aggressive isolates. After the repeated agonistic interactions the group-housed mice exhibit depressed locomotor/exploratory behaviour in a novel open field arena, which can be disinhibited by clinically used antidepressants (Steinberg H, 1990). In our experiment the group-housed mice responded to felbamate at the doses 60 and 240 mg/kg orally by a significant (p < 0.05) disinhibiton of their suppresed locomotor/exploratory behaviour, thus felbamate produced an antidepresive-like effect, which is in correspondence with clinical reports on a potential antidepressant action of felbamate." . . "\u00DA\u010Dinky felbam\u00E1tu na explora\u010Dn\u00ED chov\u00E1n\u00ED my\u0161\u00ED jsou podobn\u00E9 \u00FA\u010Dink\u016Fm antidepresiv"@cs . "2"^^ . "92-93" . "Antiepileptik\u00E1 3. generace jsou v sou\u010Dasnosti referov\u00E1ny pro jejich vyu\u017Eit\u00ED v l\u00E9\u010Db\u011B deprese. Testovali jsme proto antiepileptikum felbam\u00E1t ve zv\u00ED\u0159ec\u00EDm modelu agonistick\u00FDch interakc\u00ED skupinov\u011B-ust\u00E1jen\u00FDch my\u0161\u00ED s agresivn\u00EDmi my\u0161\u00EDmi izol\u00E1tmi. Po opakovan\u00FDch soci\u00E1ln\u00EDch interakc\u00EDch vykazuj\u00ED skupinov\u011B-ust\u00E1jen\u00E9 my\u0161i sn\u00ED\u017Eenou lokomo\u010Dn\u00ED aktivitu v testu otev\u0159en\u00E9ho pole, kter\u00E1 m\u016F\u017Ee b\u00FDt desinhibov\u00E1na p\u016Fsoben\u00EDm klinicky u\u017Eivan\u00FDch antidepresiv (Steinberg H, 1990). V na\u0161em experimentu zp\u016Fsobil felbam\u00E1t v d\u00E1vk\u00E1ch 60 a 240 mg/kg p.o. (p < 0.05) desinhibici lokomo\u010Dn\u011B-explora\u010Dn\u00EDho chov\u00E1n\u00ED skupinov\u011B-ust\u00E1jen\u00FDch my\u0161\u00ED v testu otev\u0159en\u00E9ho pole, co\u017E v souladu s klinick\u00FDmi \u00FAdaji o potenci\u00E1ln\u00EDm antidepresivn\u00EDm \u00FA\u010Dinku felbam\u00E1tu sv\u011Bd\u010D\u00ED pro mo\u017Enost jeho vyu\u017Eit\u00ED v l\u00E9\u010Db\u011B deprese."@cs . "0960-7560" . "agonistic interactions; felbamate; antidepressant; animal model"@en . . "IT - Italsk\u00E1 republika" . . "\u0160ulcov\u00E1, Alexandra" . "42" . . "2"^^ . "Antidepressive-like felbamate effects on exploratory behaviour in mice"@en . . . "Antidepressive-like felbamate effects on exploratory behaviour in mice" . . . "RIV/00216224:14110/03:00009515!RIV08-MSM-14110___" . "Z(MSM 141100001)" . "Homeostasis" . "Antidepressive-like felbamate effects on exploratory behaviour in mice"@en . . "14110" . "\u00DA\u010Dinky felbam\u00E1tu na explora\u010Dn\u00ED chov\u00E1n\u00ED my\u0161\u00ED jsou podobn\u00E9 \u00FA\u010Dink\u016Fm antidepresiv"@cs . . . . .