"RIV/00216224:14110/03:00009506" . . . "Z(MSM 141100001)" . "CZ - \u010Cesk\u00E1 republika" . . . "\u0160ulcov\u00E1, Alexandra" . "The neurobiology of methamphetamine abuse"@en . "The neurobiology of methamphetamine abuse" . . . "methamphetamine; pharmacological mechanisms; addiction; treatment"@en . "Neurobiologie z\u00E1vislosti na metamfetamin"@cs . "[24A802257A62]" . "1"^^ . "Adiktologie" . "1213-3841" . "3" . . "2"^^ . . "Goldberg, Steven" . "617736" . . "13-23" . "RIV/00216224:14110/03:00009506!RIV08-MSM-14110___" . "Methamphetamine synthesized in 1887, also known as "speed", "crank", "go", "meth", or "poor man's cocaine", was used in the clinic until the 1930s. At present methamphetamine illegal production has led to widespread problems with its abuse. Methamphetamine causes dopamine, noradrenaline and serotonin release into the synapses in areas of the brain involved in reward and movement resulting in strong and long-lasting stimulant effects with rapid onset. Chronic methamphetamine intake produces: alterations in certain brain receptors and in biochemical mechanisms that regulate normal brain functions; neurotoxic damage to serotonergic and dopaminergic neurons; psychiatric complications such as paranoia, and hallucinations. The article reports on neurobiological and behavioral studies identifying methamphetamine-induced neuroadaptations and relating them to behavioral changes contributing to reinforcement drug-taking behavior, craving and relapse. Finally, an"@en . . "14110" . . "Methamphetamine synthesized in 1887, also known as "speed", "crank", "go", "meth", or "poor man's cocaine", was used in the clinic until the 1930s. At present methamphetamine illegal production has led to widespread problems with its abuse. Methamphetamine causes dopamine, noradrenaline and serotonin release into the synapses in areas of the brain involved in reward and movement resulting in strong and long-lasting stimulant effects with rapid onset. Chronic methamphetamine intake produces: alterations in certain brain receptors and in biochemical mechanisms that regulate normal brain functions; neurotoxic damage to serotonergic and dopaminergic neurons; psychiatric complications such as paranoia, and hallucinations. The article reports on neurobiological and behavioral studies identifying methamphetamine-induced neuroadaptations and relating them to behavioral changes contributing to reinforcement drug-taking behavior, craving and relapse. Finally, an" . . "Neurobiologie z\u00E1vislosti na metamfetamin"@cs . . "2" . . "The neurobiology of methamphetamine abuse"@en . "Pod\u00E1n p\u0159ehled aktu\u00E1ln\u00EDch dat o neurobiologick\u00FDch mechanismech uplat\u0148uj\u00EDc\u00EDchc se p\u0159i vzniku, pr\u016Fb\u011Bhu a p\u0159\u00EDpadn\u011B l\u00E9\u010Den\u00ED y\u00E1vislosti na metamfetamin."@cs . "10"^^ . "The neurobiology of methamphetamine abuse" . . .