"13" . "2"^^ . . . . "European Neuropsychopharmacology" . "Antidepressant-like effects of felbamate on locomotor behaviour and leukocyte phagocytosis in rats"@en . "14110" . "1"^^ . . . . "antiepileptic; felbamate; animal model of depression; bulbectomy"@en . "\u00DA\u010Dinky felbam\u00E1tu na lokomo\u010Dn\u00ED chov\u00E1n\u00ED a leukocyt\u00E1rn\u00ED fagocyt\u00F3zu potkan\u016F jsou podobn\u00E9 \u00FA\u010Dink\u016Fm antidepresiv"@cs . "RIV/00216224:14110/03:00009203!RIV09-MSM-14110___" . "Suppl.4" . "To examine potential antidepressant effects of felbamate rats with bilateral lesion of the olfactory bulb (OB rats) were used in the present study. This animal model resembles behavioural, endocrine and immune changes found in human depression. Repeated felbamate treatment (240 mg/kg, orally, for 10 days) effects on locomotor behaviour (ambulation) in an open field test, and on leukocyte phagocytosis were studied in both sham-operated and bulbectomized rats. Felbamate elicited a significant decrease of the previously hyperactive ambulation of the OB rats after 10 days of medication (240 mg/kg/day, orally), while no marked changes were observed in sham-operated animals. On the day 10 of the felbamate treatment, there was no significant difference in locomotor activity of the OB and the sham-operated rats. Significantly suppressed leukocyte phagocytic activity recorded in OB rats was disinhibited in those treated repeatedly with felbamate while the drug did not alter phagocytosis of leukocytes in sham-o"@en . . "0924-977X" . . "Antidepressant-like effects of felbamate on locomotor behaviour and leukocyte phagocytosis in rats" . . . "Pistov\u010D\u00E1kov\u00E1, Jana" . "000185412300215" . "To examine potential antidepressant effects of felbamate rats with bilateral lesion of the olfactory bulb (OB rats) were used in the present study. This animal model resembles behavioural, endocrine and immune changes found in human depression. Repeated felbamate treatment (240 mg/kg, orally, for 10 days) effects on locomotor behaviour (ambulation) in an open field test, and on leukocyte phagocytosis were studied in both sham-operated and bulbectomized rats. Felbamate elicited a significant decrease of the previously hyperactive ambulation of the OB rats after 10 days of medication (240 mg/kg/day, orally), while no marked changes were observed in sham-operated animals. On the day 10 of the felbamate treatment, there was no significant difference in locomotor activity of the OB and the sham-operated rats. Significantly suppressed leukocyte phagocytic activity recorded in OB rats was disinhibited in those treated repeatedly with felbamate while the drug did not alter phagocytosis of leukocytes in sham-o" . . . "CZ - \u010Cesk\u00E1 republika" . . . "Antidepressant-like effects of felbamate on locomotor behaviour and leukocyte phagocytosis in rats"@en . . "Antidepressant-like effects of felbamate on locomotor behaviour and leukocyte phagocytosis in rats" . . . "[917B5D15E9DE]" . "RIV/00216224:14110/03:00009203" . "\u00DA\u010Dinky felbam\u00E1tu na lokomo\u010Dn\u00ED chov\u00E1n\u00ED a leukocyt\u00E1rn\u00ED fagocyt\u00F3zu potkan\u016F jsou podobn\u00E9 \u00FA\u010Dink\u016Fm antidepresiv"@cs . "2"^^ . "Model olfaktorick\u00E9 bulbektomie hlodavc\u016F p\u0159edstavuje zv\u00ED\u0159ec\u00ED model deprese. Ve zm\u00EDn\u011Bn\u00E9m modelu jsme testovali \u00FA\u010Dinky opakovan\u00E9ho pod\u00E1v\u00E1n\u00ED felbam\u00E1tu (240 mg/kg, p.o., deset dn\u016F) na lokomo\u010Dn\u00ED chov\u00E1n\u00ED v testu otev\u0159en\u00E9ho pole a leukocyt\u00E1rn\u00ED fagocyt\u00F3zu kontroln\u00EDch a bulbektomovan\u00FDch potkan\u016F. Felbam\u00E1t signifikantn\u011B sn\u00ED\u017Eil typickou motorickou hyperaktivitu bulbektomovan\u00FDch potkan\u016F, zat\u00EDmco neovlivnil lokomoci kontroln\u00EDch zv\u00ED\u0159at. Sn\u00ED\u017Een\u00E1 leukocyt\u00E1rn\u00ED fagocyt\u00F3za bulbektomovan\u00FDch potkan\u016F byla desinhibovan\u00E1 po desetidenn\u00EDm pod\u00E1v\u00E1n\u00ED felbam\u00E1tu. Behavior\u00E1ln\u00ED a imuninitn\u00ED data sv\u011Bd\u010D\u00ED pro potenci\u00E1ln\u011B antidepresivn\u00ED \u00FA\u010Dinky felbam\u00E1tu."@cs . "598589" . "Z(MSM 141100001)" . "\u0160ulcov\u00E1, Alexandra" .