"EFFECTS OF AMISULPRIDE ON LOCOMOTOR BEHAVIOUR AND LEUKOCYTE PHAGOCYTOSIS IN RAT MODEL OF DEPRESSION"@en . "605275" . "2003-01-01+01:00"^^ . . "14110" . "Antwerp" . "Antwerp" . . . "Amisulpride, an atypical antipsychotic agent, in low doses preferentially blocks D2 and D3 dopamine autoreceptors in the limbic system. In our pre-clinical experiment we used the bilaterally-bulbectomized rat model of depression to examine whether amisulpride reduces the characteristic hyperactive locomotor responses in these rats exposed in the open-field test. Apart from the behavioural changes also amisulpride effects on the immune function of leukocyte phagocytosis in both sham-operated and bulbectomized rats were tested. Leukocyte zymosan induced phagocytosis was evaluated according to luminol aided chemiluminescence in vitro after repeated administration of amisulpride in vivo. OB rats showed a significant increase in ambulation and rearing scores in the open-field test, and suppressed leukocyte phagocytic function compared to the sham-operated rats. Repeated amisulpride administration (7mg/kg/day, intraperitoneally, for 7 days) resulted in a significant suppression of the motor hyperactivity of"@en . "EFFECTS OF AMISULPRIDE ON LOCOMOTOR BEHAVIOUR AND LEUKOCYTE PHAGOCYTOSIS IN RAT MODEL OF DEPRESSION" . "Lippincott Williams&Wilkins" . . . . . "RIV/00216224:14110/03:00008889!RIV/2004/MSM/141104/N" . "0955-8810" . "\u0160ulcov\u00E1, Alexandra" . "EFFECTS OF AMISULPRIDE ON LOCOMOTOR BEHAVIOUR AND LEUKOCYTE PHAGOCYTOSIS IN RAT MODEL OF DEPRESSION"@en . . . "[71857A3A0004]" . "Z(MSM 141100001)" . . . "olfactory bulbectomy, amisulpride, antidepressant"@en . "RIV/00216224:14110/03:00008889" . . "2"^^ . "Amisulpride, an atypical antipsychotic agent, in low doses preferentially blocks D2 and D3 dopamine autoreceptors in the limbic system. In our pre-clinical experiment we used the bilaterally-bulbectomized rat model of depression to examine whether amisulpride reduces the characteristic hyperactive locomotor responses in these rats exposed in the open-field test. Apart from the behavioural changes also amisulpride effects on the immune function of leukocyte phagocytosis in both sham-operated and bulbectomized rats were tested. Leukocyte zymosan induced phagocytosis was evaluated according to luminol aided chemiluminescence in vitro after repeated administration of amisulpride in vivo. OB rats showed a significant increase in ambulation and rearing scores in the open-field test, and suppressed leukocyte phagocytic function compared to the sham-operated rats. Repeated amisulpride administration (7mg/kg/day, intraperitoneally, for 7 days) resulted in a significant suppression of the motor hyperactivity of" . "0"^^ . "EFFECTS OF AMISULPRIDE ON LOCOMOTOR BEHAVIOUR AND LEUKOCYTE PHAGOCYTOSIS IN RAT MODEL OF DEPRESSION" . . "40" . "2"^^ . "0"^^ . . "Pistov\u010D\u00E1kov\u00E1, Jana" . . . "Behavioural Pharmacology" . . "1"^^ .