"11320" . . "4"^^ . . . "DNA hairpin molecules with periodic base sequences can be expected to exhibit a regular coarse-grained free energy landscape (FEL) as a function of the number of open base pairs and applied mechanical force. Using a commonly employed model, we first analyze for which types of sequences a particularly simple landscape structure is predicted, where forward and backward energy barriers between partly unfolded states are decreasing linearly with force. Stochastic unfolding trajectories for such molecules with simple FEL are subsequently generated by kinetic Monte Carlo simulations. Introducing probabilities that can be sampled from these trajectories, it is shown how the parameters characterizing the FEL can be estimated. Already 300 trajectories, as typically generated in experiments, provide faithful results for the FEL parameters." . . . . "DNA hairpin molecules with periodic base sequences can be expected to exhibit a regular coarse-grained free energy landscape (FEL) as a function of the number of open base pairs and applied mechanical force. Using a commonly employed model, we first analyze for which types of sequences a particularly simple landscape structure is predicted, where forward and backward energy barriers between partly unfolded states are decreasing linearly with force. Stochastic unfolding trajectories for such molecules with simple FEL are subsequently generated by kinetic Monte Carlo simulations. Introducing probabilities that can be sampled from these trajectories, it is shown how the parameters characterizing the FEL can be estimated. Already 300 trajectories, as typically generated in experiments, provide faithful results for the FEL parameters."@en . "0953-8984" . "26" . "11"^^ . "000336244900004" . "Unfolding kinetics of periodic DNA hairpins" . . "51938" . "Journal of Physics Condensed Matter" . "DNA sequences; free energy landscape; DNA unfolding; single molecule experiment; nonequilibrium kinetics"@en . . "10.1088/0953-8984/26/20/205102" . . "Holubec, Viktor" . . . "Unfolding kinetics of periodic DNA hairpins"@en . "Unfolding kinetics of periodic DNA hairpins" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . "Unfolding kinetics of periodic DNA hairpins"@en . "Chvosta, Petr" . "[0221EDF65892]" . "S" . . "http://dx.doi.org/10.1088/0953-8984/26/20/205102" . . "Nostheide, Sandra" . . "RIV/00216208:11320/14:10286287!RIV15-MSM-11320___" . "20" . "RIV/00216208:11320/14:10286287" . "Maass, Philipp" . . "2"^^ .