"Alexandre, Michel W." . . "PLoS ONE" . . . "Swanson, Priscilla" . . "Laeyendecker, Oliver" . "Background: National Institute of Mental Health Project Accept (HIV Prevention Trials Network [HPTN] 043) is a large, Phase III, community-randomized, HIV prevention trial conducted in 48 matched communities in Africa and Thailand. The study intervention included enhanced community-based voluntary counseling and testing. The primary endpoint was HIV incidence, assessed in a single, cross-sectional, post-intervention survey of >50,000 participants. Methods: HIV rapid tests were performed in-country. HIV status was confirmed at a central laboratory in the United States. HIV incidence was estimated using a multi-assay algorithm (MAA) that included the BED capture immunoassay, an avidity assay, CD4 cell count, and HIV viral load. Results: Data from Thailand was not used in the endpoint analysis because HIV prevalence was low. Overall, 7,361 HIV infections were identified (4 acute, 3 early, and 7,354 established infections). Samples from established infections were analyzed using the MAA; 467 MAA positive samples were identified; 29 of those samples were excluded because they contained antiretroviral drugs. HIV prevalence was 16.5% (range at study sites: 5.93% to 30.8%). HIV incidence was 1.60% (range at study sites: 0.78% to 3.90%). Conclusions: In this community-randomized trial, a MAA was used to estimate HIV incidence in a single, cross-sectional post-intervention survey. Results from this analysis were subsequently used to compare HIV incidence in the control and intervention communities."@en . "9"^^ . "RIV/00216208:11320/13:10172642" . . "Gray, Glenda" . "http://dx.doi.org/10.1371/journal.pone.0068349" . . "[6FBA3DDF007B]" . "RIV/00216208:11320/13:10172642!RIV14-MSM-11320___" . "1"^^ . . "Bassuk, Deb" . . "Celentano, David D." . "Chin, Craig" . "Sweat, Michael" . . "Fiamma, Agnes" . "Hackett, John jr." . . "Background: National Institute of Mental Health Project Accept (HIV Prevention Trials Network [HPTN] 043) is a large, Phase III, community-randomized, HIV prevention trial conducted in 48 matched communities in Africa and Thailand. The study intervention included enhanced community-based voluntary counseling and testing. The primary endpoint was HIV incidence, assessed in a single, cross-sectional, post-intervention survey of >50,000 participants. Methods: HIV rapid tests were performed in-country. HIV status was confirmed at a central laboratory in the United States. HIV incidence was estimated using a multi-assay algorithm (MAA) that included the BED capture immunoassay, an avidity assay, CD4 cell count, and HIV viral load. Results: Data from Thailand was not used in the endpoint analysis because HIV prevalence was low. Overall, 7,361 HIV infections were identified (4 acute, 3 early, and 7,354 established infections). Samples from established infections were analyzed using the MAA; 467 MAA positive samples were identified; 29 of those samples were excluded because they contained antiretroviral drugs. HIV prevalence was 16.5% (range at study sites: 5.93% to 30.8%). HIV incidence was 1.60% (range at study sites: 0.78% to 3.90%). Conclusions: In this community-randomized trial, a MAA was used to estimate HIV incidence in a single, cross-sectional post-intervention survey. Results from this analysis were subsequently used to compare HIV incidence in the control and intervention communities." . "Eshleman, Susan H." . "Morin, Stephen F." . "Clarke, William" . "000322218800027" . "Estimation of HIV Incidence in a Large, Community-Based, Randomized Clinical Trial: NIMH Project Accept (HIV Prevention Trials Network 043)"@en . "Szekeres, Greg" . . . "7" . "1932-6203" . "risk; intervention; thailand; united-states; sub-saharan africa"@en . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Marzinke, Mark" . "Mullis, Caroline E." . "Chingono, Alfred" . "Estimation of HIV Incidence in a Large, Community-Based, Randomized Clinical Trial: NIMH Project Accept (HIV Prevention Trials Network 043)" . . "Chariyalertsak, Suwat" . "10.1371/journal.pone.0068349" . "23"^^ . "Estimation of HIV Incidence in a Large, Community-Based, Randomized Clinical Trial: NIMH Project Accept (HIV Prevention Trials Network 043)"@en . . "73279" . "Donnell, Deborah" . "Piwowar-Manning, Estelle" . "Coates, Thomas" . "N" . . "Kulich, Michal" . "Estimation of HIV Incidence in a Large, Community-Based, Randomized Clinical Trial: NIMH Project Accept (HIV Prevention Trials Network 043)" . "11320" . "8" . "Richter, Linda" . .