"Mar\u0161\u00EDk, Franti\u0161ek" . . . . "11320" . . "Human Biomechanics 2008" . . . . "2008-01-01+01:00"^^ . "Bone remodeling driven by dynamic loading and drug treatment"@en . . "RIV/00216208:11320/08:00100246" . "Bone remodeling driven by dynamic loading and drug treatment" . . "Czech Society of Biomechanics Charles Univerzity in Prague" . "Kostn\u00ED remodelace poh\u00E1n\u011Bn\u00E1 dynamick\u00FDm zat\u011B\u017Eov\u00E1n\u00EDm a o\u0161et\u0159ov\u00E1n\u00EDm l\u00E9\u010Divy"@cs . "Bone remodeling driven by dynamic loading and drug treatment" . "Prague" . "Prague" . "Remodela\u010Dn\u00ED proces v kosti je postaven na biochemick\u00E9m popisu v\u010Detn\u011B RANKL-RANK-OPG \u0159et\u011Bzce. Rychlost ka\u017Ed\u00E9 chemick\u00E9 reakce je siln\u011B ovliv\u0148ov\u00E1na dynamick\u00FDm zat\u011B\u017Eov\u00E1n\u00EDm a to je d\u016Fvod, pro\u010D model je schopen popsat vliv dynamick\u00E9ho zat\u011B\u017Eov\u00E1n\u00ED spolu s mechanismy biochemick\u00E9ho \u0159\u00EDzen\u00ED (nap\u0159. osteoprotegerin) - eventu\u00E1ln\u011B o\u0161et\u0159ov\u00E1n\u00ED l\u00E9\u010Divy. Prezentovan\u00FD model kostn\u00ED adaptace ukazuje chov\u00E1n\u00ED, kter\u00E9 vykazuje shodu s experiment\u00E1ln\u00EDmi (a klinick\u00FDmi) zku\u0161enostmi a z\u00E1v\u011Bry. Proto\u017Ee hlavn\u00ED limituj\u00EDc\u00ED faktor doby \u017Eivotnosti v\u011Bt\u0161iny prot\u00E9z je necht\u011Bn\u00E1 adaptace kosti na nov\u00E9 podm\u00EDnky zat\u011B\u017Eov\u00E1n\u00ED, pou\u017Eili jsme zm\u00EDn\u011Bn\u00FD model pro p\u0159edpov\u00EDd\u00E1n\u00ED reakce kosti."@cs . . . . . "P(GA106/08/0557)" . "978-80-01-04163-5" . "358371" . . "Kostn\u00ED remodelace poh\u00E1n\u011Bn\u00E1 dynamick\u00FDm zat\u011B\u017Eov\u00E1n\u00EDm a o\u0161et\u0159ov\u00E1n\u00EDm l\u00E9\u010Divy"@cs . . "1"^^ . . "remodeling; driven; dynamic; loading; treatment"@en . "The bone remodelling process is based on its biochemical description including RANKL-RANK-OPG chain. The rate of each chemical reaction strongly depends on dynamic loading and that is why the model is able to describe the influence of dynamic loading together with biochemical control mechanisms (e.g. osteoprotegerin) possibly drug treatment. The presented model of bone adaptation show behaviour that has good corelation with experimental (and clinical) experience and results. Because the main factor limiting the lifetime of many prosthesis is unwanted adaptation of bone to the new loading condition, we use mentioned model to predict the response of bone."@en . "[8375677F245B]" . "2"^^ . "Klika, V\u00E1clav" . "1"^^ . . . "Bone remodeling driven by dynamic loading and drug treatment"@en . "RIV/00216208:11320/08:00100246!RIV09-GA0-11320___" . "The bone remodelling process is based on its biochemical description including RANKL-RANK-OPG chain. The rate of each chemical reaction strongly depends on dynamic loading and that is why the model is able to describe the influence of dynamic loading together with biochemical control mechanisms (e.g. osteoprotegerin) possibly drug treatment. The presented model of bone adaptation show behaviour that has good corelation with experimental (and clinical) experience and results. Because the main factor limiting the lifetime of many prosthesis is unwanted adaptation of bone to the new loading condition, we use mentioned model to predict the response of bone." .