"We report the backbone 1H, 13C and 15N assignments of NMR resonances for the 47 kDa Cytosolic dNT-1 nucleotidase dimer. Cytosolic dNT-1 nucleotidase plays a key role in the homeostasis of pyrimidine deoxyribonucleotides in mammalian cells. The enzyme is responsible for the dephosphorylation of physiological substrates as well as nucleoside analogues that are used in antiviral and anticancer therapies, therefore selective inhibition of the dNT-1 nucleotidase activity may lead to an increase in efficacy of this type of therapeutic compounds. Here, we report the backbone H-1, C-13 and N-15 assignments for the 47 kDa dNT-1 dimer, which will be used for structural characterisation of dNT-1 complexes with small molecule inhibitors obtained through modification of pyrimidine nucleotide scaffolds or optimisation of successful binders obtained from the screening of fragment libraries."@en . "4748" . "1874-2718" . . . "11310" . "Skleni\u010Dkov\u00E1, Radka" . . . "We report the backbone 1H, 13C and 15N assignments of NMR resonances for the 47 kDa Cytosolic dNT-1 nucleotidase dimer. Cytosolic dNT-1 nucleotidase plays a key role in the homeostasis of pyrimidine deoxyribonucleotides in mammalian cells. The enzyme is responsible for the dephosphorylation of physiological substrates as well as nucleoside analogues that are used in antiviral and anticancer therapies, therefore selective inhibition of the dNT-1 nucleotidase activity may lead to an increase in efficacy of this type of therapeutic compounds. Here, we report the backbone H-1, C-13 and N-15 assignments for the 47 kDa dNT-1 dimer, which will be used for structural characterisation of dNT-1 complexes with small molecule inhibitors obtained through modification of pyrimidine nucleotide scaffolds or optimisation of successful binders obtained from the screening of fragment libraries." . . "Backbone resonance assignments of human cytosolic dNT-1 nucleotidase"@en . "Backbone resonance assignments of human cytosolic dNT-1 nucleotidase" . . . . . . . "Backbone resonance assignments of human cytosolic dNT-1 nucleotidase" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "1"^^ . "Veverka, V\u00E1clav" . "RIV/00216208:11310/14:10196792!RIV15-MSM-11310___" . . "4"^^ . "pyrimidine nucleotides; dimer; perdeuterated protein; 5 '-nucleotidase; haloacid dehalogenase superfamily; NMR; backbone assignments"@en . . "F\u00E1bry, Milan" . "Hn\u00EDzda, Ale\u0161" . "10.1007/s12104-013-9531-1" . "RIV/00216208:11310/14:10196792" . . "7"^^ . "[A2D96FD79640]" . "To\u0161ner, Zden\u011Bk" . "I, P(GA203/09/0820), P(LK11205)" . "Brynda, Ji\u0159\u00ED" . "8" . . . . "Biomolecular NMR Assignments" . . "http://link.springer.com/article/10.1007/s12104-013-9531-1" . "000342080900042" . "2" . "Pachl, Petr" . . "Backbone resonance assignments of human cytosolic dNT-1 nucleotidase"@en . .