. "Lazar, Adina N." . "Arlicot, Nicolas" . . . . "Buron, Frederic" . "1948-5875" . . . "1"^^ . . . "Guilloteau, Denis" . . "Morfin, Jean-Francois" . "[9DB7A3B4A0EB]" . "Suzenet, Franck" . "Geraldes, Carlos F. G. C." . "11310" . . "10.1021/ml400042w" . "Salerno, Milena" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Toth, Eva" . "000318892800005" . "5"^^ . . . . "RIV/00216208:11310/13:10139591" . . "Duyckaerts, Charles" . "RIV/00216208:11310/13:10139591!RIV14-MSM-11310___" . "I, S" . "5" . . "Kubicek, Vojt\u011Bch" . "PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of beta-Amyloid Plaques"@en . . "PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of beta-Amyloid Plaques"@en . "13"^^ . "96213" . "PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of beta-Amyloid Plaques" . "4" . "Martins, Andre F." . "In an effort toward the visualization of beta-amyloid plaques by in vivo imaging techniques, we have conjugated an optimized derivative of the Pittsburgh compound B (PiB), a well-established marker of Afi plaques, to DO3A-monoamide that is capable of forming stable, noncharged complexes with different trivalent metal ions including Gd3+ for MRI and In-111(3+). for SPECT applications. Proton relaxivity measurements evidenced binding of Gd(DO3A-PiB) to the amyloid peptide A beta(1-40) and to human serum albumin, resulting in a two- and four-fold relaidvity increase, respectively. Ex vivo immunohistochemical studies showed that the DO3A-PiB complexes selectively target A beta plaques on Alzheimer's disease human brain tissue. Ex vivo biodistribution data obtained for the In-111-analogue pointed to a moderate blood-brain barrier (BBB) penetration in adult male Swiss mice (without amyloid deposits) with 0.36% ID/g in the cortex at 2 min postinjection." . "Kub\u00ED\u010Dkov\u00E1, Anna" . . "PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of beta-Amyloid Plaques" . "Pittsburgh compound B; Alzheimer's disease; amyloid plaques; In-111(3+); Gd3+; imaging agents"@en . "http://dx.doi.org/10.1021/ml400042w" . "In an effort toward the visualization of beta-amyloid plaques by in vivo imaging techniques, we have conjugated an optimized derivative of the Pittsburgh compound B (PiB), a well-established marker of Afi plaques, to DO3A-monoamide that is capable of forming stable, noncharged complexes with different trivalent metal ions including Gd3+ for MRI and In-111(3+). for SPECT applications. Proton relaxivity measurements evidenced binding of Gd(DO3A-PiB) to the amyloid peptide A beta(1-40) and to human serum albumin, resulting in a two- and four-fold relaidvity increase, respectively. Ex vivo immunohistochemical studies showed that the DO3A-PiB complexes selectively target A beta plaques on Alzheimer's disease human brain tissue. Ex vivo biodistribution data obtained for the In-111-analogue pointed to a moderate blood-brain barrier (BBB) penetration in adult male Swiss mice (without amyloid deposits) with 0.36% ID/g in the cortex at 2 min postinjection."@en . . "ACS Medicinal Chemistry Letters" .