"Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism" . "46" . "\u010C\u00E1p, Michal" . "Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth. Here, we identify metabolic and regulatory parallels between a layered, multicellular yeast colony and a tumor-affected organism. During development, a yeast colony stratifies into U and L cells occupying the upper and lower colony regions, respectively. U cells activate a unique metabolism controlled by the glutamine-induced TOR pathway, amino acid sensing systems (SPS and Gcn4p) and signaling from mitochondria with lowered respiration. These systems jointly modulate U cell physiology, which adapts to nutrient limitations and utilize the nutrients released from L cells. Stress-resistant U cells share metabolic pathways and other similar characteristics with tumor cells, including the ability to proliferate. L cells behave similarly to stressed and starving cells, which activate degradative mechanisms to provide nutrients to U cells. Our data suggest a nutrient flow between both cell types, resembling the Cori cycle and glutamine-NH4 + shuttle between tumor and healthy metazoan cells." . "RIV/00216208:11310/12:10120765!RIV13-GA0-11310___" . "5"^^ . . "4" . "Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism"@en . . "1097-2765" . . "[97F096800C7E]" . "Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth. Here, we identify metabolic and regulatory parallels between a layered, multicellular yeast colony and a tumor-affected organism. During development, a yeast colony stratifies into U and L cells occupying the upper and lower colony regions, respectively. U cells activate a unique metabolism controlled by the glutamine-induced TOR pathway, amino acid sensing systems (SPS and Gcn4p) and signaling from mitochondria with lowered respiration. These systems jointly modulate U cell physiology, which adapts to nutrient limitations and utilize the nutrients released from L cells. Stress-resistant U cells share metabolic pathways and other similar characteristics with tumor cells, including the ability to proliferate. L cells behave similarly to stressed and starving cells, which activate degradative mechanisms to provide nutrients to U cells. Our data suggest a nutrient flow between both cell types, resembling the Cori cycle and glutamine-NH4 + shuttle between tumor and healthy metazoan cells."@en . . . . "RIV/00216208:11310/12:10120765" . . . . "amino acid sensing systems; TOR pathway; U and L cells; yeast colony; metabolic reprogramming; nutrient sensing"@en . "10.1016/j.molcel.2012.04.001" . . "126223" . . . . . . . . "http://www.cell.com/molecular-cell/abstract/S1097-2765(12)00266-3" . "11310" . "Molecular Cell" . . . "I, P(GA204/08/0718), P(LC531), Z(MSM0021620858)" . . "Palkov\u00E1, Zdena" . "V\u00E1chov\u00E1, Libu\u0161e" . . . "Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism" . "13"^^ . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Harant, Karel" . . "4"^^ . . "000304518900008" . "\u0160t\u011Bp\u00E1nek, Lud\u011Bk" . "Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism"@en . .