"Increased serum prolactin (PRL) levels have been demonstrated in several autoimmune diseases including polymyositis (PM) and systemic sclerosis (SSc). Its extrapituitary promoter contains functional single nucleotide polymorphism (SNP) -1149 G/T in the GATA sequence; G allele leads to higher PRL mRNA in lymphocytes synthesis. We looked for distribution of allele and genotype of the -1149 G/T SNP of the extrapituitary PRL promoter in 75 patients with SSc, in 47 subjects with PM, in 68 patients with dermatomyositis (DM), and in 123 healthy Czech subjects. The genotype and allele distribution did not show any significant differences in groups of PM, DM, and SSc patients compared to healthy individuals. We found a significant inverse association between TT genotype in SSc patients with disease onset after 45 years compared to individuals with SSc and diseases onset prior to 45 years." . . "12" . "6"^^ . "30" . "11310" . . . . "\u010Cejkov\u00E1, Pavl\u00EDna" . "10.1007/s00296-009-1284-x" . "\u010Cern\u00E1, Marie" . "Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis" . "RIV/00216208:11310/10:10080384!RIV13-MSM-11310___" . "V, Z(MSM0021620828)" . "Fojt\u00EDkov\u00E1, Mark\u00E9ta" . "polymorphism; gene; prolactin; systemic sclerosis"@en . "000283503200027" . . "Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis"@en . . "Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis"@en . . . "RIV/00216208:11310/10:10080384" . "Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis" . . "0172-8172" . . "[100704D12999]" . . "1"^^ . . . . "Vencovsk\u00FD, Ji\u0159\u00ED" . "Rheumatology International" . . . "3"^^ . . "Tomasov\u00E1-stud\u00FDnk, Jana" . "Be\u010Dv\u00E1\u0159, Radim" . "279794" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "Increased serum prolactin (PRL) levels have been demonstrated in several autoimmune diseases including polymyositis (PM) and systemic sclerosis (SSc). Its extrapituitary promoter contains functional single nucleotide polymorphism (SNP) -1149 G/T in the GATA sequence; G allele leads to higher PRL mRNA in lymphocytes synthesis. We looked for distribution of allele and genotype of the -1149 G/T SNP of the extrapituitary PRL promoter in 75 patients with SSc, in 47 subjects with PM, in 68 patients with dermatomyositis (DM), and in 123 healthy Czech subjects. The genotype and allele distribution did not show any significant differences in groups of PM, DM, and SSc patients compared to healthy individuals. We found a significant inverse association between TT genotype in SSc patients with disease onset after 45 years compared to individuals with SSc and diseases onset prior to 45 years."@en .