. "Nov\u00E1kov\u00E1, Kate\u0159ina" . "300722" . . "pentacyclic and tetracyclic terpenoids"@en . . . "Univerzita Karlova v Praze, P\u0159\u00EDrodov\u011Bdeck\u00E1 fakulta, Praha, CZ; Univerzita Palack\u00E9ho v Olomouci, Olomouc, CZ; I.Q.A., a. s., Praha, CZ" . "2009-06-15+02:00"^^ . . "The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water-insoluble terpenoid having a free carboxylic, hydroxy or amino functional group is derivatized on this functional group with a selected substituent and subsequently, the prepared derivative is dissolved in the solution containing water, a cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the cyclodextrin. Object of the invention is further a soluble formulation of a pentacyclic or tetracyclic triterpenoid, containing an inclusion complex of the derivatized pentacyclic or tetracyclic terpenoid with a cyclodextrin, and optionally water and pharmaceutically acceptable auxiliary substances and further a pharmaceutical composition containing the soluble formulation."@en . "\u00DA\u0159ad pr\u016Fmyslov\u00E9ho vlastnictv\u00ED; http://www.upv.cz" . "Zp\u016Fsob p\u0159\u00EDpravy inkluzn\u00EDho komplexu pentacyklick\u00FDch a tetracyklick\u00FDch terpenoid\u016F a farmaceutick\u00E9ho prost\u0159edku obsahuj\u00EDc\u00EDho tento inkluzn\u00ED komplex, inkluzn\u00ED komplex pentacyklick\u00E9ho nebo tetracyklick\u00E9ho terpenoidu a farmaceutick\u00FD prost\u0159edek obsahuj\u00EDc\u00ED"@cs . "Zp\u016Fsob p\u0159\u00EDpravy inkluzn\u00EDho komplexu pentacyklick\u00FDch a tetracyklick\u00FDch terpenoid\u016F a farmaceutick\u00E9ho prost\u0159edku obsahuj\u00EDc\u00EDho tento inkluzn\u00ED komplex, inkluzn\u00ED komplex pentacyklick\u00E9ho nebo tetracyklick\u00E9ho terpenoidu a farmaceutick\u00FD prost\u0159edek obsahuj\u00EDc\u00ED"@cs . . "4"^^ . . . "1"^^ . "Praha" . . "\u0160arek, Jan" . "Zp\u016Fsob p\u0159\u00EDpravy inkluzn\u00EDho komplexu pentacyklick\u00FDch a tetracyklick\u00FDch terpenoid\u016F a farmaceutick\u00E9ho prost\u0159edku obsahuj\u00EDc\u00EDho tento inkluzn\u00ED komplex, inkluzn\u00ED komplex pentacyklick\u00E9ho nebo tetracyklick\u00E9ho terpenoidu a farmaceutick\u00FD prost\u0159edek obsahuj\u00EDc\u00ED" . . "11310" . "METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION"@en . . . "Svoboda, Michal" . "Je pops\u00E1n zp\u016Fsob p\u0159\u00EDpravy inkluzn\u00EDch komplex\u016F pentacyklick\u00FDch a tetracyklick\u00FDch terpenoid\u016F, p\u0159i n\u011Bm\u017E se ve vod\u011B nerozpustn\u00FD pentacyklick\u00FD nebo tetracyklick\u00FD terpenoid maj\u00EDc\u00ED volnou karboxylovou, hydroxylovou nebo amino funk\u010Dn\u00ED skupinu derivatizuje na t\u00E9to funk\u010Dn\u00ED skupin\u011B vybran\u00FDm substituentem a n\u00E1sledn\u011B se p\u0159ipraven\u00FD deriv\u00E1t rozpust\u00ED v roztoku obsahuj\u00EDc\u00EDm vodu a nativn\u00ED nebo substituovan\u00FD gama-cyklodextrin za tvorby inkluzn\u00EDho komplexu, na\u010De\u017E se inkluzn\u00ED komplex s uveden\u00FDm cyklodextrinem izoluje z vodn\u00E9ho roztoku, s v\u00FDhodou lyofilizac\u00ED. Pops\u00E1na je i p\u0159\u00EDprava farmaceutick\u00E9ho prost\u0159edku obsahuj\u00EDc\u00EDho tento inkluzn\u00ED komplex. D\u00E1le je pops\u00E1n inkluzn\u00ED komplex derivatizovan\u00E9ho pentacyklick\u00E9ho nebo tetracyklick\u00E9ho terpenoidu a nativn\u00EDho nebo substituovan\u00E9ho gama-cyklodextrinu a d\u00E1le farmaceutick\u00FD prost\u0159edek obsahuj\u00EDc\u00ED tento inkluzn\u00ED komplex." . "RIV/00216208:11310/09:10000489" . "RIV/00216208:11310/09:10000489!RIV11-MSM-11310___" . "METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION"@en . "Zp\u016Fsob p\u0159\u00EDpravy inkluzn\u00EDho komplexu pentacyklick\u00FDch a tetracyklick\u00FDch terpenoid\u016F a farmaceutick\u00E9ho prost\u0159edku obsahuj\u00EDc\u00EDho tento inkluzn\u00ED komplex, inkluzn\u00ED komplex pentacyklick\u00E9ho nebo tetracyklick\u00E9ho terpenoidu a farmaceutick\u00FD prost\u0159edek obsahuj\u00EDc\u00ED" . "[027C07EFF503]" . . "Je pops\u00E1n zp\u016Fsob p\u0159\u00EDpravy inkluzn\u00EDch komplex\u016F pentacyklick\u00FDch a tetracyklick\u00FDch terpenoid\u016F, p\u0159i n\u011Bm\u017E se ve vod\u011B nerozpustn\u00FD pentacyklick\u00FD nebo tetracyklick\u00FD terpenoid maj\u00EDc\u00ED volnou karboxylovou, hydroxylovou nebo amino funk\u010Dn\u00ED skupinu derivatizuje na t\u00E9to funk\u010Dn\u00ED skupin\u011B vybran\u00FDm substituentem a n\u00E1sledn\u011B se p\u0159ipraven\u00FD deriv\u00E1t rozpust\u00ED v roztoku obsahuj\u00EDc\u00EDm vodu a nativn\u00ED nebo substituovan\u00FD gama-cyklodextrin za tvorby inkluzn\u00EDho komplexu, na\u010De\u017E se inkluzn\u00ED komplex s uveden\u00FDm cyklodextrinem izoluje z vodn\u00E9ho roztoku, s v\u00FDhodou lyofilizac\u00ED. Pops\u00E1na je i p\u0159\u00EDprava farmaceutick\u00E9ho prost\u0159edku obsahuj\u00EDc\u00EDho tento inkluzn\u00ED komplex. D\u00E1le je pops\u00E1n inkluzn\u00ED komplex derivatizovan\u00E9ho pentacyklick\u00E9ho nebo tetracyklick\u00E9ho terpenoidu a nativn\u00EDho nebo substituovan\u00E9ho gama-cyklodextrinu a d\u00E1le farmaceutick\u00FD prost\u0159edek obsahuj\u00EDc\u00ED tento inkluzn\u00ED komplex."@cs . "Hajd\u00FAch, Mari\u00E1n" . . . . . . "I, S, V" . . . "353554" .