"Ellipticin tvo\u0159\u00ED kovalentn\u00ED adukty s DNA, po aktivaci cvytochromy P450 a peroxidasami. Byla porovn\u00E1na role jatern\u00EDho a mimojatern\u00EDho metabolismu pou\u017Eit\u00EDm s cytochrom P450 reduktaza deficientn\u00EDho my\u0161\u00EDho modelu."@cs . . . . "[099F5ECDF8B8]" . "P(1M0505), P(GA203/06/0329), Z(MSM0021620808)" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . . "4"^^ . "10"^^ . . "Role jatern\u00EDch cytochrom\u016F P450 p\u0159i biotransformaci protin\u00E1dorov\u00E9ho l\u00E9\u010Diva ellipticinu"@cs . . "393184" . . "Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse"@en . "3" . "Hude\u010Dek, Ji\u0159\u00ED" . . . "0041-008X" . . "226" . . "Kotrbov\u00E1, V\u011Bra" . . "9"^^ . "RIV/00216208:11310/08:13541!RIV09-MSM-11310___" . "Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse"@en . "Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse" . . "Toxicology and applied pharmacology" . . . "Role jatern\u00EDch cytochrom\u016F P450 p\u0159i biotransformaci protin\u00E1dorov\u00E9ho l\u00E9\u010Diva ellipticinu"@cs . . . "11310" . "Ellipticine is an antineoplastic agent, which forms covalent DNA adducts mediated by cytochromes P450 and peroxidases. We evaluated the role of hepatic versus extra-hepatic metabolism of ellipticine, using the Hepatic Cytochrome P450 Reductase Null mouse"@en . . "anticancer drug; ellipticine; cytochrome P450; peroxidase; DNA adducts; P-32-postlabelling; dna adduct formation; prostaglandin-h synthase; environmental-pollutant 3-nitrobenzanthrone; metabolic-activation; determines susceptibility; xenobiotic-metabolism; liver-microsomes; oxidation; enzymes; mice"@en . . "Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse" . "Stiborov\u00E1, Marie" . . . "Ellipticine is an antineoplastic agent, which forms covalent DNA adducts mediated by cytochromes P450 and peroxidases. We evaluated the role of hepatic versus extra-hepatic metabolism of ellipticine, using the Hepatic Cytochrome P450 Reductase Null mouse" . . . . . . . "Moserov\u00E1, Michaela" . . . "RIV/00216208:11310/08:13541" . "000253002200011" . . . . .