"Praktick\u00E9 l\u00E9k\u00E1renstv\u00ED" . "Mal\u00FD, Josef" . "4"^^ . "Proper functioning of the immune system is necessary for the maintenance of homeostasis of the organism. In the medical context, however, there are situations in which self-defense may be unwanted in its consequences. By suppressing immunity we stabilize the course of several diseases of autoimmune or chronic inflammatory origin, thereby preventing rejection of transplanted organs and tissues (bone marrow, kidneys, liver and heart). The disadvantage of immunosuppression is its long term course and non-selective effects; the organism is not able to resist to infection agents for a long time, with resulting an early failure of antitumor surveillance. Immunosuppressive drugs are characterized by many unwanted effects including most often development of arterial hypertension, disturbances in metabolism (obesity, dyslipidemia or hyperglycemia) and organ damage (kidneys and liver)."@en . . "2"^^ . "http://www.praktickelekarenstvi.cz/pdfs/lek/2011/05/01.pdf" . . "Kortikosteroidy a imunosupresiva v chronick\u00E9 l\u00E9\u010Db\u011B"@cs . "2"^^ . . "7" . . "Corticosteroids and immunosuppression in chronic treatment"@en . "Kortikosteroidy a imunosupresiva v chronick\u00E9 l\u00E9\u010Db\u011B" . "Kortikosteroidy a imunosupresiva v chronick\u00E9 l\u00E9\u010Db\u011B"@cs . . "11160" . . "Corticosteroids and immunosuppression in chronic treatment"@en . "Spr\u00E1vn\u00E1 funkce imunitn\u00EDho syst\u00E9mu je nezbytn\u00E1 pro udr\u017Een\u00ED st\u00E1losti vnit\u0159n\u00EDho prost\u0159ed\u00ED organizmu neboli homeost\u00E1zy. V \u0161irok\u00E9 medic\u00EDnsk\u00E9 problematice nicm\u00E9n\u011B existuj\u00ED situace, kdy je vlastn\u00ED obranyschopnost ve sv\u00E9m d\u016Fsledku ne\u017E\u00E1douc\u00ED. Potla\u010Den\u00EDm imunity stabilizujeme pr\u016Fb\u011Bh \u0159ady onemocn\u011Bn\u00ED autoimunitn\u00EDho, p\u0159\u00EDpadn\u011B chronick\u00E9ho z\u00E1n\u011Btliv\u00E9ho p\u016Fvodu a p\u0159edch\u00E1z\u00EDme rejekci transplantovan\u00FDch org\u00E1n\u016F a tk\u00E1n\u00ED (kostn\u00ED d\u0159e\u0148, ledviny, j\u00E1tra, srdce). Nev\u00FDhodou imunosuprese je jej\u00ED dlouhodobost a neselektivn\u00ED p\u016Fsoben\u00ED, kdy organizmus nen\u00ED schopen dlouhodob\u011B odol\u00E1vat infek\u010Dn\u00EDm \u010Dinitel\u016Fm a doch\u00E1z\u00ED k \u010Dasn\u00E9mu selh\u00E1n\u00ED protin\u00E1dorov\u00E9ho dohledu. Imunosupresivn\u00ED l\u00E9ky se vyzna\u010Duj\u00ED mnoh\u00FDmi ne\u017E\u00E1douc\u00EDmi \u00FA\u010Dinky, nej\u010Dast\u011Bji sklonem k arteri\u00E1ln\u00ED hypertenzi, poruch\u00E1m metabolizmu (obezita, dyslipid\u00E9mie, hyperglyk\u00E9mie) a org\u00E1nov\u00FDm po\u0161kozen\u00EDm (ledviny, j\u00E1tra) (1). Nej\u0161ir\u0161\u00EDho uplatn\u011Bn\u00ED v klinick\u00E9 praxi dos\u00E1hly kortikosteroidy, nejv\u011Bt\u0161\u00EDho pokroku bylo v posledn\u00ED dob\u011B dosa\u017Eeno v oblasti v\u00FDvoje biologick\u00FDch prepar\u00E1t\u016F."@cs . "208225" . "Kortikosteroidy a imunosupresiva v chronick\u00E9 l\u00E9\u010Db\u011B" . . . "S" . . "Spr\u00E1vn\u00E1 funkce imunitn\u00EDho syst\u00E9mu je nezbytn\u00E1 pro udr\u017Een\u00ED st\u00E1losti vnit\u0159n\u00EDho prost\u0159ed\u00ED organizmu neboli homeost\u00E1zy. V \u0161irok\u00E9 medic\u00EDnsk\u00E9 problematice nicm\u00E9n\u011B existuj\u00ED situace, kdy je vlastn\u00ED obranyschopnost ve sv\u00E9m d\u016Fsledku ne\u017E\u00E1douc\u00ED. Potla\u010Den\u00EDm imunity stabilizujeme pr\u016Fb\u011Bh \u0159ady onemocn\u011Bn\u00ED autoimunitn\u00EDho, p\u0159\u00EDpadn\u011B chronick\u00E9ho z\u00E1n\u011Btliv\u00E9ho p\u016Fvodu a p\u0159edch\u00E1z\u00EDme rejekci transplantovan\u00FDch org\u00E1n\u016F a tk\u00E1n\u00ED (kostn\u00ED d\u0159e\u0148, ledviny, j\u00E1tra, srdce). Nev\u00FDhodou imunosuprese je jej\u00ED dlouhodobost a neselektivn\u00ED p\u016Fsoben\u00ED, kdy organizmus nen\u00ED schopen dlouhodob\u011B odol\u00E1vat infek\u010Dn\u00EDm \u010Dinitel\u016Fm a doch\u00E1z\u00ED k \u010Dasn\u00E9mu selh\u00E1n\u00ED protin\u00E1dorov\u00E9ho dohledu. Imunosupresivn\u00ED l\u00E9ky se vyzna\u010Duj\u00ED mnoh\u00FDmi ne\u017E\u00E1douc\u00EDmi \u00FA\u010Dinky, nej\u010Dast\u011Bji sklonem k arteri\u00E1ln\u00ED hypertenzi, poruch\u00E1m metabolizmu (obezita, dyslipid\u00E9mie, hyperglyk\u00E9mie) a org\u00E1nov\u00FDm po\u0161kozen\u00EDm (ledviny, j\u00E1tra) (1). Nej\u0161ir\u0161\u00EDho uplatn\u011Bn\u00ED v klinick\u00E9 praxi dos\u00E1hly kortikosteroidy, nejv\u011Bt\u0161\u00EDho pokroku bylo v posledn\u00ED dob\u011B dosa\u017Eeno v oblasti v\u00FDvoje biologick\u00FDch prepar\u00E1t\u016F." . . . . . "biological treatment; immunosuppression; corticosteroids"@en . "RIV/00216208:11160/11:10100587" . . "1801-2434" . "5" . "RIV/00216208:11160/11:10100587!RIV12-MSM-11160___" . "CZ - \u010Cesk\u00E1 republika" . "[690A89A73DAF]" . . . "Rudolf, Kamil" .