. "Kessler, Petr" . . "20" . . "11150" . . "Diagnostika a l\u00E9\u010Dba mnoho\u010Detn\u00E9ho myelomu" . "Krej\u010D\u00ED, Marta" . "17"^^ . . "Plonkov\u00E1, Hana" . "Diagnostika a l\u00E9\u010Dba mnoho\u010Detn\u00E9ho myelomu"@cs . . . . "310196" . "Schutzov\u00E1, Miroslava" . . "\u0160pi\u010Dka, Ivan" . "Transfuze a hematologie dnes" . . "RIV/00216208:11150/14:10286262" . "2"^^ . "I, P(NR8183), P(NR9317), V" . "Diagnostika a l\u00E9\u010Dba mnoho\u010Detn\u00E9ho myelomu" . . "1213-5763" . "This supplement contains revision of guidelines for treatment of multiple myeloma with lenalidomide and new guidelines for treatment of multiple myeloma with pomalidomide and carfilzomib."@en . "Mina\u0159\u00EDk, Ji\u0159\u00ED" . "Adam, Zden\u011Bk" . . "Maisnar, Vladim\u00EDr" . "Za zcela nejd\u016Fle\u017Eit\u011Bj\u0161\u00ED pova\u017Eujeme vy\u0159e\u0161enou problematiku bezpe\u010Dnosti pod\u00E1v\u00E1n\u00ED lenalidomidu. Zv\u00FD\u0161en\u00E9 riziko sekund\u00E1rn\u00EDch prim\u00E1rn\u00EDch n\u00E1dor\u016F po primol\u00E9\u010Db\u011B bylo prok\u00E1z\u00E1no jen v p\u0159\u00EDpad\u011B pou\u017Eit\u00ED kombinace lenalidomidu s peror\u00E1ln\u00EDm melfalanem. Tuto kombinaci tedy nedoporu\u010Dujeme nad\u00E1le pou\u017E\u00EDvat v l\u00E9\u010Db\u011B mnoho\u010Detn\u00E9ho myelomu obecn\u011B. Za z\u00E1sadn\u00ED pova\u017Eujeme fakt, \u017Ee limitovan\u00E1 l\u00E9\u010Dba lenalidomidem m\u00E1 v\u00FDznamn\u011B hor\u0161\u00ED v\u00FDsledky ne\u017E dlouhodob\u00E1 kontinu\u00E1ln\u00ED l\u00E9\u010Dba a\u017E do relapsu onemocn\u011Bn\u00ED. V\u011B\u0159me, \u017Ee v\u00FDsledky dosa\u017Een\u00E9 jak v r\u00E1mci \u010CR, tak i v multicentrick\u00FDch randomizovan\u00FDch studi\u00EDch povedou k racion\u00E1ln\u00EDmu vyu\u017Eit\u00ED l\u00E9\u010Debn\u00FDch mo\u017Enost\u00ED bez st\u00E1vaj\u00EDc\u00EDch omezen\u00ED, kter\u00E1 nejsou prosp\u011B\u0161n\u00E1 l\u00E9\u010Debn\u011B ani ekonomicky. Nov\u00E9 mimo\u0159\u00E1dn\u011B \u00FA\u010Dinn\u00E9 l\u00E9ky pomalidomid a carfilzomib indikovan\u00E9 v relapsu \u010Di progresi onemocn\u011Bn\u00ED u nemocn\u00FDch refraktern\u00EDch na lenalidomid a bortezomib nepochybn\u011B d\u00E1le zlep\u0161\u00ED celkov\u00E9 v\u00FDsledky na\u0161\u00ED l\u00E9\u010Dby."@cs . "Gregora, Ev\u017Een" . . . . . "Diagnosis and treatment of multiple myeloma"@en . . "Supplementum" . "Za zcela nejd\u016Fle\u017Eit\u011Bj\u0161\u00ED pova\u017Eujeme vy\u0159e\u0161enou problematiku bezpe\u010Dnosti pod\u00E1v\u00E1n\u00ED lenalidomidu. Zv\u00FD\u0161en\u00E9 riziko sekund\u00E1rn\u00EDch prim\u00E1rn\u00EDch n\u00E1dor\u016F po primol\u00E9\u010Db\u011B bylo prok\u00E1z\u00E1no jen v p\u0159\u00EDpad\u011B pou\u017Eit\u00ED kombinace lenalidomidu s peror\u00E1ln\u00EDm melfalanem. Tuto kombinaci tedy nedoporu\u010Dujeme nad\u00E1le pou\u017E\u00EDvat v l\u00E9\u010Db\u011B mnoho\u010Detn\u00E9ho myelomu obecn\u011B. Za z\u00E1sadn\u00ED pova\u017Eujeme fakt, \u017Ee limitovan\u00E1 l\u00E9\u010Dba lenalidomidem m\u00E1 v\u00FDznamn\u011B hor\u0161\u00ED v\u00FDsledky ne\u017E dlouhodob\u00E1 kontinu\u00E1ln\u00ED l\u00E9\u010Dba a\u017E do relapsu onemocn\u011Bn\u00ED. V\u011B\u0159me, \u017Ee v\u00FDsledky dosa\u017Een\u00E9 jak v r\u00E1mci \u010CR, tak i v multicentrick\u00FDch randomizovan\u00FDch studi\u00EDch povedou k racion\u00E1ln\u00EDmu vyu\u017Eit\u00ED l\u00E9\u010Debn\u00FDch mo\u017Enost\u00ED bez st\u00E1vaj\u00EDc\u00EDch omezen\u00ED, kter\u00E1 nejsou prosp\u011B\u0161n\u00E1 l\u00E9\u010Debn\u011B ani ekonomicky. Nov\u00E9 mimo\u0159\u00E1dn\u011B \u00FA\u010Dinn\u00E9 l\u00E9ky pomalidomid a carfilzomib indikovan\u00E9 v relapsu \u010Di progresi onemocn\u011Bn\u00ED u nemocn\u00FDch refraktern\u00EDch na lenalidomid a bortezomib nepochybn\u011B d\u00E1le zlep\u0161\u00ED celkov\u00E9 v\u00FDsledky na\u0161\u00ED l\u00E9\u010Dby." . "\u0160\u010Dudla, Vlastimil" . . . "H\u00E1jek, Roman" . "carfilzomib; pomalidomide; lenalidomide; multiple myeloma; treatment; guidelines"@en . "CZ - \u010Cesk\u00E1 republika" . . . "Pavl\u00ED\u010Dek, Petr" . "Pour, Lud\u011Bk" . "Straub, Jan" . "Diagnosis and treatment of multiple myeloma"@en . . "Radocha, Jakub" . "RIV/00216208:11150/14:10286262!RIV15-MSM-11150___" . "Diagnostika a l\u00E9\u010Dba mnoho\u010Detn\u00E9ho myelomu"@cs . "[DF623E1CE53A]" . "15"^^ .