"RIV/00216208:11150/14:10284085" . "93" . . . . "Du\u0161ek, Tom\u00E1\u0161" . "Sotona, Otakar" . "RIV/00216208:11150/14:10284085!RIV15-MSM-11150___" . . "[847104D6F097]" . "30775" . . . "CZ - \u010Cesk\u00E1 republika" . "Ferko, Alexander" . "Hovorkov\u00E1, Eva" . "Mo\u017Enosti predikce pN pozitivity u T3 n\u00E1dor\u016F rekta"@cs . "C\u00EDlem pr\u00E1ce je anal\u00FDza prediktivn\u00EDch faktor\u016F, kter\u00E9 maj\u00ED vliv na vznik metastatick\u00E9ho posti\u017Een\u00ED uzlin u T3 karcinomu rekta. Zhodnocena byla skupina pacient\u016F s resek\u010Dn\u00EDm v\u00FDkonem pro (y)pT3 karcinom rekta operovan\u00FDch na chirurgick\u00E9 klinice Fakultn\u00ED nemocnice v Hradci Kr\u00E1lov\u00E9 v obdob\u00ED od 1. 1. 2011 do 28. 2. 2014. Data byla sb\u00EDr\u00E1na prospektivn\u011B a ukl\u00E1d\u00E1na do registru pro karcinom rekta. Sledovan\u00FDmi parametry byly v\u011Bk, pohlav\u00ED, lokalizace n\u00E1doru, cirkumferentn\u00ED topografie n\u00E1doru, hloubka penetrace n\u00E1doru do mezorekta, po\u010Det odebran\u00FDch a pozitivn\u00EDch uzlin, grading, p\u0159\u00EDtomnost angioinvaze, lymfangioinvaze a perineur\u00E1ln\u00EDho \u0161\u00ED\u0159en\u00ED a podstoupen\u00ED neoadjuvantn\u00ED (chemo)radioterapie.Do studie bylo za\u0159azeno 89 pacient\u016F s T3 karcinomem rekta. Resekce pro karcinom horn\u00EDho rekta byla provedena u 22 (24,7 %) pacient\u016F, st\u0159edn\u00EDho rekta u 37 (41,6 %) a doln\u00EDho rekta 30 (33,7 %) pacient\u016F. Prim\u00E1rn\u011B operov\u00E1no bylo 38 (42,7 %) pacient\u016F, neoadjuvantn\u00ED chemoradioterapii m\u011Blo 41 (46,1 %) pacient\u016F, oz\u00E1\u0159en\u00EDm bylo l\u00E9\u010Deno 10 (11,2 %) pacient\u016F. Stadium pN+ bylo zji\u0161t\u011Bno u 51 (57,3 %) pacient\u016F. Statistickou anal\u00FDzou byly identifikov\u00E1ny rizikov\u00E9 faktory pro pN+: lymfangioinvaze (pLESS-THAN OR EQUAL TO0,001), angioinvaze (p=0,030) a perineur\u00E1ln\u00ED \u0161\u00ED\u0159en\u00ED tumoru (p=0,010). Na hranici statistick\u00E9 v\u00FDznamnosti pro pN+ byl zji\u0161t\u011Bn vliv n\u00EDzk\u00E9ho gradingu tumoru (p=0,084). Hloubka penetrace n\u00E1doru do mezorekta nebyla statisticky v\u00FDznamn\u00E1 (p=0,230). Na\u0161e studie prok\u00E1zala, \u017Ee pN pozitivita u T3 tumor\u016F rekta je spojena s lymfovaskul\u00E1rn\u00ED invaz\u00ED, perineur\u00E1ln\u00EDm \u0161\u00ED\u0159en\u00EDm a n\u00EDzk\u00FDm gradingem n\u00E1doru. P\u0159esn\u00E1 identifikace t\u011Bchto faktor\u016F p\u0159ed l\u00E9\u010Dbou je ale zat\u00EDm st\u00E1le obt\u00ED\u017En\u00E1." . "The aim of the study is to analyze the predictive factors determining lymph node involvement in T3 rectal cancer. Patients with rectal resection for (y)pT3 rectal cancer were analysed. All of the surgical interventions were performed at the Department of Surgery, University Hospital in Hradec Kralove, from 1 January 2011 to 28 February 2014. Data were prospectively collected and saved in the Rectal Cancer Oncologic Register. The parameters studied were age, gender, tumour localisation and its circumferential topography, preoperative chemoradiotherapy, absolute number of harvested lymph nodes and the number of positive lymph nodes in each specimen, umour grading,presence of lymphovascular invasion and perineural invasion and the depth of tumour penetration. After selection, 89 patients with T3 rectal cancer were included into the study. Resection for cancer of the upper rectum was performed in 22 patients, middle rectum in 37 and lower rectum in 30 patients. 38 patients underwent primary operation, 41 patients received neoadjuvant chemoradiotherapy and radiation therapy was administered to only 10 patients. Stage pN+ was found in 51patients. Statistical analysis was used to identify the risk factors for pN+:lymphovascular invasion, angioinvasion and perineural invasion. On the border of statistical significance for pN+, low grading of the tumour was found. The depth of penetration of the tumour into the mesorectum was not statistically significant. Our study has shown that pN positivity is associated with lymphovascular invasion, perineural invasion and low grading of the tumour. Accurate identification of these factors before treatment, however, remains very difficult."@en . "7"^^ . . . "11150" . "12" . "Chobola, Milan" . "C\u00EDlem pr\u00E1ce je anal\u00FDza prediktivn\u00EDch faktor\u016F, kter\u00E9 maj\u00ED vliv na vznik metastatick\u00E9ho posti\u017Een\u00ED uzlin u T3 karcinomu rekta. Zhodnocena byla skupina pacient\u016F s resek\u010Dn\u00EDm v\u00FDkonem pro (y)pT3 karcinom rekta operovan\u00FDch na chirurgick\u00E9 klinice Fakultn\u00ED nemocnice v Hradci Kr\u00E1lov\u00E9 v obdob\u00ED od 1. 1. 2011 do 28. 2. 2014. Data byla sb\u00EDr\u00E1na prospektivn\u011B a ukl\u00E1d\u00E1na do registru pro karcinom rekta. Sledovan\u00FDmi parametry byly v\u011Bk, pohlav\u00ED, lokalizace n\u00E1doru, cirkumferentn\u00ED topografie n\u00E1doru, hloubka penetrace n\u00E1doru do mezorekta, po\u010Det odebran\u00FDch a pozitivn\u00EDch uzlin, grading, p\u0159\u00EDtomnost angioinvaze, lymfangioinvaze a perineur\u00E1ln\u00EDho \u0161\u00ED\u0159en\u00ED a podstoupen\u00ED neoadjuvantn\u00ED (chemo)radioterapie.Do studie bylo za\u0159azeno 89 pacient\u016F s T3 karcinomem rekta. Resekce pro karcinom horn\u00EDho rekta byla provedena u 22 (24,7 %) pacient\u016F, st\u0159edn\u00EDho rekta u 37 (41,6 %) a doln\u00EDho rekta 30 (33,7 %) pacient\u016F. Prim\u00E1rn\u011B operov\u00E1no bylo 38 (42,7 %) pacient\u016F, neoadjuvantn\u00ED chemoradioterapii m\u011Blo 41 (46,1 %) pacient\u016F, oz\u00E1\u0159en\u00EDm bylo l\u00E9\u010Deno 10 (11,2 %) pacient\u016F. Stadium pN+ bylo zji\u0161t\u011Bno u 51 (57,3 %) pacient\u016F. Statistickou anal\u00FDzou byly identifikov\u00E1ny rizikov\u00E9 faktory pro pN+: lymfangioinvaze (pLESS-THAN OR EQUAL TO0,001), angioinvaze (p=0,030) a perineur\u00E1ln\u00ED \u0161\u00ED\u0159en\u00ED tumoru (p=0,010). Na hranici statistick\u00E9 v\u00FDznamnosti pro pN+ byl zji\u0161t\u011Bn vliv n\u00EDzk\u00E9ho gradingu tumoru (p=0,084). Hloubka penetrace n\u00E1doru do mezorekta nebyla statisticky v\u00FDznamn\u00E1 (p=0,230). Na\u0161e studie prok\u00E1zala, \u017Ee pN pozitivita u T3 tumor\u016F rekta je spojena s lymfovaskul\u00E1rn\u00ED invaz\u00ED, perineur\u00E1ln\u00EDm \u0161\u00ED\u0159en\u00EDm a n\u00EDzk\u00FDm gradingem n\u00E1doru. P\u0159esn\u00E1 identifikace t\u011Bchto faktor\u016F p\u0159ed l\u00E9\u010Dbou je ale zat\u00EDm st\u00E1le obt\u00ED\u017En\u00E1."@cs . . "lymph node involvement; perineural invasion; lymphovascular invasion; mesorectal extension depth; T3 rectal cancer"@en . . "7"^^ . "Predicting pN positivity in T3 rectal cancer"@en . . "Had\u017Ei Nikolov, Dimitar" . . . "I" . . "Predicting pN positivity in T3 rectal cancer"@en . . "\u00D6rhalmi, Julius" . "5"^^ . . "Mo\u017Enosti predikce pN pozitivity u T3 n\u00E1dor\u016F rekta" . "Rozhledy v chirurgii" . "Mo\u017Enosti predikce pN pozitivity u T3 n\u00E1dor\u016F rekta" . . . . . . . "0035-9351" . "Mo\u017Enosti predikce pN pozitivity u T3 n\u00E1dor\u016F rekta"@cs .