"RIV/00216208:11150/14:10283857" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Pl\u00ED\u0161kov\u00E1, Lenka" . . "http://dx.doi.org/10.1016/j.ajog.2014.03.069" . "RIV/00216208:11150/14:10283857!RIV15-MSM-11150___" . "Jacobsson, Bo" . "9"^^ . "11150" . "American Journal of Obstetrics and Gynecology" . . "211" . "Kutov\u00E1, Radka" . . "10.1016/j.ajog.2014.03.069" . "4"^^ . "Ko\u0161\u0165\u00E1l, Milan" . "Hornychov\u00E1, Helena" . "4972" . "I" . "OBJECTIVE: The objective of the study was to determine the diagnostic indices and predictive values by bedside assessment of amniotic fluid interleukin-6 (IL-6) concentration in the identification of microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA) in patients with preterm prelabor rupture of membranes. STUDY DESIGN: One hundred twenty-four women with singleton pregnancies were included in this study. The amniotic fluid was sampled by transabdominal amniocentesis at the time of admission. IL-6 concentrations were assessed with an immunoassay. RESULTS: The presence of MIAC, HCA, or the coexistence of both was associated with higher amniotic fluid concentrations of IL-6 in both a crude and adjusted analysis. The amniotic fluid concentration of IL-6 of 1000 pg/mL was determined to be the best cutoff value for the prediction of MIAC (sensitivity of 50%, specificity of 95%, positive predictive value of 82%, negative predictive value of 81%, and likelihood ratio of 8.4) or both MIAC and HCA (sensitivity of 60%, specificity of 94%, positive predictive value of 75%, negative predictive value of 88%, and likelihood ratio of 9.4). CONCLUSION: The bedside assessment of amniotic fluid IL-6 seems to be an easy, rapid, and inexpensive method for the prediction of MIAC or both MIAC and HCA in pregnancies complicated by preterm prelabor rupture of membranes."@en . . . . . . "Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes"@en . "[CE940204F3DF]" . "OBJECTIVE: The objective of the study was to determine the diagnostic indices and predictive values by bedside assessment of amniotic fluid interleukin-6 (IL-6) concentration in the identification of microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA) in patients with preterm prelabor rupture of membranes. STUDY DESIGN: One hundred twenty-four women with singleton pregnancies were included in this study. The amniotic fluid was sampled by transabdominal amniocentesis at the time of admission. IL-6 concentrations were assessed with an immunoassay. RESULTS: The presence of MIAC, HCA, or the coexistence of both was associated with higher amniotic fluid concentrations of IL-6 in both a crude and adjusted analysis. The amniotic fluid concentration of IL-6 of 1000 pg/mL was determined to be the best cutoff value for the prediction of MIAC (sensitivity of 50%, specificity of 95%, positive predictive value of 82%, negative predictive value of 81%, and likelihood ratio of 8.4) or both MIAC and HCA (sensitivity of 60%, specificity of 94%, positive predictive value of 75%, negative predictive value of 88%, and likelihood ratio of 9.4). CONCLUSION: The bedside assessment of amniotic fluid IL-6 seems to be an easy, rapid, and inexpensive method for the prediction of MIAC or both MIAC and HCA in pregnancies complicated by preterm prelabor rupture of membranes." . . "Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes"@en . "7"^^ . . "Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes" . . "Musilov\u00E1, Ivana" . . "Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes" . . "0002-9378" . "000342572200020" . "microbial invasion of the amniotic fluid; interleukin-6; histological chorioamnionitis; cytokine; amniotic fluid"@en . "Kacerovsk\u00FD, Marian" . . . "4" . . . .