"Nekvindov\u00E1, Jana" . "CZ - \u010Cesk\u00E1 republika" . . "153" . "MikroRNA a ledviny"@cs . "11150" . "I" . "St\u0159\u00EDtesk\u00E1, Jana" . . . . . "\u010Casopis l\u00E9ka\u0159\u016F \u010Desk\u00FDch" . . . . . "6"^^ . . "RIV/00216208:11150/14:10283682!RIV15-MSM-11150___" . "MikroRNA a ledviny" . "biomarkers; gene expression profiles; diabetic nephropathy; acute kidney injury; microRNA"@en . . "MikroRNA jsou kr\u00E1tk\u00E9 nek\u00F3duj\u00EDc\u00ED molekuly ribonukleov\u00E9 kyseliny, kter\u00E9 p\u016Fsob\u00ED jako regul\u00E1tory genov\u00E9 exprese na post-transkrip\u010Dn\u00ED \u00FArovni. Regulac\u00ED genov\u00E9 exprese zasahuj\u00ED do d\u016Fle\u017Eit\u00FDch fyziologick\u00FDch i patofyziologick\u00FDch d\u011Bj\u016F v organismu, nap\u0159. bun\u011B\u010Dn\u00E9 diferenciace, proliferace, apopt\u00F3zy, metabolismu, a patogeneze mnoha onemocn\u011Bn\u00ED v\u010Detn\u011B karcinogeneze. Mnoh\u00E9 mikroRNA jsou tk\u00E1\u0148ov\u011B \u010Di org\u00E1nov\u011B specifick\u00E9. Sou\u010Dasn\u00FD v\u00FDzkum se zab\u00FDv\u00E1 mo\u017Enostmi vyu\u017Eit\u00ED mikroRNA jako biomarker\u016F, p\u0159\u00EDpadn\u011B terapeutik. D\u016Fle\u017Eitou roli maj\u00ED mikroRNA nejen pro spr\u00E1vn\u00E9 fyziologick\u00E9 funkce a v\u00FDvoj ledvin, ale i v patogenezi onemocn\u011Bn\u00ED ledvin. Intenzivn\u00ED v\u00FDzkum v t\u00E9to oblasti je zam\u011B\u0159en zejm\u00E9na na n\u00E1dorov\u00E1 onemocn\u011Bn\u00ED ledvin a mo\u010Dov\u00E9ho \u00FAstroj\u00ED, akutn\u00ED po\u0161kozen\u00ED ledvin, chronick\u00E1 onemocn\u011Bn\u00ED ledvin (polycystick\u00E1 choroba ledvin), p\u0159\u00EDpadn\u011B ren\u00E1ln\u00ED komplikace syst\u00E9mov\u00FDch onemocn\u011Bn\u00ED (diabetick\u00E1 a hypertenzn\u00ED nefropatie, imunitn\u00ED po\u0161kozen\u00ED ledvin v\u010Detn\u011B akutn\u00ED rejekce transplantovan\u00E9 ledviny). V p\u0159ehledu jsou uvedeny z\u00E1kladn\u00ED informace o ovlivn\u011Bn\u00ED v\u00FDvoje a funkce ledvin a patogeneze nej\u010Dast\u011Bj\u0161\u00EDch onemocn\u011Bn\u00ED ledvin prost\u0159ednictv\u00EDm mikroRNA."@cs . . "MikroRNA a ledviny" . "MikroRNA a ledviny"@cs . "Pali\u010Dka, Vladim\u00EDr" . . "RIV/00216208:11150/14:10283682" . . "29361" . "2"^^ . . "MikroRNA jsou kr\u00E1tk\u00E9 nek\u00F3duj\u00EDc\u00ED molekuly ribonukleov\u00E9 kyseliny, kter\u00E9 p\u016Fsob\u00ED jako regul\u00E1tory genov\u00E9 exprese na post-transkrip\u010Dn\u00ED \u00FArovni. Regulac\u00ED genov\u00E9 exprese zasahuj\u00ED do d\u016Fle\u017Eit\u00FDch fyziologick\u00FDch i patofyziologick\u00FDch d\u011Bj\u016F v organismu, nap\u0159. bun\u011B\u010Dn\u00E9 diferenciace, proliferace, apopt\u00F3zy, metabolismu, a patogeneze mnoha onemocn\u011Bn\u00ED v\u010Detn\u011B karcinogeneze. Mnoh\u00E9 mikroRNA jsou tk\u00E1\u0148ov\u011B \u010Di org\u00E1nov\u011B specifick\u00E9. Sou\u010Dasn\u00FD v\u00FDzkum se zab\u00FDv\u00E1 mo\u017Enostmi vyu\u017Eit\u00ED mikroRNA jako biomarker\u016F, p\u0159\u00EDpadn\u011B terapeutik. D\u016Fle\u017Eitou roli maj\u00ED mikroRNA nejen pro spr\u00E1vn\u00E9 fyziologick\u00E9 funkce a v\u00FDvoj ledvin, ale i v patogenezi onemocn\u011Bn\u00ED ledvin. Intenzivn\u00ED v\u00FDzkum v t\u00E9to oblasti je zam\u011B\u0159en zejm\u00E9na na n\u00E1dorov\u00E1 onemocn\u011Bn\u00ED ledvin a mo\u010Dov\u00E9ho \u00FAstroj\u00ED, akutn\u00ED po\u0161kozen\u00ED ledvin, chronick\u00E1 onemocn\u011Bn\u00ED ledvin (polycystick\u00E1 choroba ledvin), p\u0159\u00EDpadn\u011B ren\u00E1ln\u00ED komplikace syst\u00E9mov\u00FDch onemocn\u011Bn\u00ED (diabetick\u00E1 a hypertenzn\u00ED nefropatie, imunitn\u00ED po\u0161kozen\u00ED ledvin v\u010Detn\u011B akutn\u00ED rejekce transplantovan\u00E9 ledviny). V p\u0159ehledu jsou uvedeny z\u00E1kladn\u00ED informace o ovlivn\u011Bn\u00ED v\u00FDvoje a funkce ledvin a patogeneze nej\u010Dast\u011Bj\u0161\u00EDch onemocn\u011Bn\u00ED ledvin prost\u0159ednictv\u00EDm mikroRNA." . "0008-7335" . "4"^^ . "4" . "MicroRNAs and kidneys"@en . "MicroRNAs and kidneys"@en . "\u010Cern\u00FD, Vladim\u00EDr" . "MicroRNAs are short non-coding ribonucleic acid molecules that regulate gene expression at the post-transcriptional level thus affecting important physiological as well as pathophysiological processes in the organism, for example cell differentiation, proliferation, apoptosis, and metabolism. They are involved in pathogenesis of many diseases including cancer. Many microRNAs are tissue or organ-specific which implies their possible potential as biomarkers or maybe even therapeutical agents as documented by microRNA research interest rising exponentially during last years. Among all, microRNAs are important also for physiological function of the kidney and they are involved in various renal disorders. Today research is focused mainly on renal and urinary tract carcinogenesis, acute kidney injury, chronic renal diseases (polycystic kidney disease) or renal complications of systemic diseases such as diabetic or hypertension nephropathy and autoimmune kidney injury including acute allograft rejection after kidney transplantation. The review summarizes current information about microRNA effect on kidney development and function and also on the most common kidney diseases."@en . "[095162E771C8]" . . .