"I, P(LM2010004), S" . "2"^^ . "Morphological and electrophysiological changes of the heart atria in necropsy patients with atrial fibrillation - a pilot study"@en . "RIV/00216208:11150/14:10283646!RIV15-MSM-11150___" . "Morfologick\u00E9 a elektrofyziologick\u00E9 zm\u011Bny v srde\u010Dn\u00EDch s\u00EDn\u00EDch zem\u0159el\u00FDch s fibrilac\u00ED s\u00EDn\u00ED - pilotn\u00ED studie"@cs . "Fibrilace s\u00EDn\u00ED (FS), nej\u010Dast\u011Bj\u0161\u00ED supraventrikul\u00E1rn\u00ED tachykardie, je spojov\u00E1na s p\u0159estavbou s\u00ED\u0148ov\u00E9ho myokardu, kter\u00E1 n\u00E1sledn\u011B vede ke vzniku abnormalit ve veden\u00ED vzruchu s\u00EDn\u011Bmi. Jedn\u00E1 se o remodelaci na elektrick\u00E9, kontraktiln\u00ED a struktur\u00E1ln\u00ED \u00FArovni. V p\u0159edkl\u00E1dan\u00E9 pilotn\u00ED studii jsme se pokusili oz\u0159ejmit souvislost mezi morfologick\u00FDmi (jizven\u00ED, amyloid\u00F3za, zv\u011Bt\u0161en\u00ED lev\u00E9 s\u00EDn\u011B) a elektrofyziologick\u00FDmi (EKG charakteristiky P vlny) zm\u011Bnami u pacient\u016F s FS. Makroskopicky a histologicky bylo vy\u0161et\u0159eno 40 srdc\u00ED zem\u0159el\u00FDch pacient\u016F (20 s anamn\u00E9zou FS, 20 bez anamn\u00E9zy FS). U v\u0161ech pacient\u016F za\u010Dlen\u011Bn\u00FDch do studie byl k dispozici EKG z\u00E1znam. Makroskopicky byla hodnocena p\u0159edev\u0161\u00EDm hmotnost srdce a velikost lev\u00E9 s\u00EDn\u011B (LS). Histologicky bylo vy\u0161et\u0159eno 7 standardizovan\u00FDch lokalit z obou srde\u010Dn\u00EDch s\u00EDn\u00ED. Ve v\u0161ech vzorc\u00EDch byla hodnocena t\u00ED\u017Ee jizven\u00ED a rozsah depozice izolovan\u00E9ho s\u00ED\u0148ov\u00E9ho amyloidu (IAA). Na EKG z\u00E1znamech byla hodnocena P vlna. Nepoda\u0159ilo se prok\u00E1zat v\u00FDznamn\u00FD rozd\u00EDl v charakteristik\u00E1ch P vlny mezi pacienty s a bez anamn\u00E9zy FS. Morfologicky m\u011Bli pacienti s FS ve srovn\u00E1n\u00ED s kontroln\u00ED skupinou signifikantn\u011B t\u011B\u017E\u0161\u00ED srdce, s objemn\u011Bj\u0161\u00ED LS, s v\u00FDrazn\u011Bji zjizvenou svalovinou LS a mezis\u00ED\u0148ov\u00E9ho septa a se z\u00E1va\u017En\u011Bj\u0161\u00EDm posti\u017Een\u00EDm obou s\u00EDn\u00ED amyloid\u00F3zou. Distribuce fibr\u00F3zy i depozit IAA byla v jednotliv\u00FDch odd\u00EDlech srde\u010Dn\u00EDch s\u00EDn\u00ED nerovnom\u011Brn\u00E1. V LS byla nejt\u011B\u017E\u0161\u00ED fibr\u00F3za u pacient\u016F s FS v oblasti stropu, nejv\u00FDrazn\u011Bj\u0161\u00ED amyloid\u00F3za v oblasti p\u0159edn\u00ED st\u011Bny. V obou skupin\u00E1ch byla v\u00FDrazn\u011Bj\u0161\u00ED amyloid\u00F3za v lev\u00E9 s\u00EDni ne\u017Eli v prav\u00E9. Pozoruhodn\u00FDm n\u00E1lezem byla nep\u0159\u00EDtomnost IAA v sinoatri\u00E1ln\u00EDm uzlu p\u0159evodn\u00EDho syst\u00E9mu. Nesouvisl\u00E9 distribuce struktur\u00E1ln\u00EDch zm\u011Bn myokardu s\u00EDn\u00ED by bylo mo\u017En\u00E9 vyu\u017E\u00EDt k ur\u010Den\u00ED vhodn\u00E9ho m\u00EDsta pro odb\u011Br vzork\u016F k histologick\u00E9 diagnostice a p\u0159isp\u011Bt by mohla i kardiolog\u016Fm v terapii arytmi\u00ED, k lep\u0161\u00EDmu zac\u00EDlen\u00ED radiofrekven\u010Dn\u00ED ablace." . "5"^^ . . "2"^^ . . "http://www.prolekare.cz/cesko-slovenska-patologie?confirm_rules=1" . "\u010Cesko-slovensk\u00E1 patologie a Soudn\u00ED l\u00E9ka\u0159stv\u00ED" . . . "Fibrilace s\u00EDn\u00ED (FS), nej\u010Dast\u011Bj\u0161\u00ED supraventrikul\u00E1rn\u00ED tachykardie, je spojov\u00E1na s p\u0159estavbou s\u00ED\u0148ov\u00E9ho myokardu, kter\u00E1 n\u00E1sledn\u011B vede ke vzniku abnormalit ve veden\u00ED vzruchu s\u00EDn\u011Bmi. Jedn\u00E1 se o remodelaci na elektrick\u00E9, kontraktiln\u00ED a struktur\u00E1ln\u00ED \u00FArovni. V p\u0159edkl\u00E1dan\u00E9 pilotn\u00ED studii jsme se pokusili oz\u0159ejmit souvislost mezi morfologick\u00FDmi (jizven\u00ED, amyloid\u00F3za, zv\u011Bt\u0161en\u00ED lev\u00E9 s\u00EDn\u011B) a elektrofyziologick\u00FDmi (EKG charakteristiky P vlny) zm\u011Bnami u pacient\u016F s FS. Makroskopicky a histologicky bylo vy\u0161et\u0159eno 40 srdc\u00ED zem\u0159el\u00FDch pacient\u016F (20 s anamn\u00E9zou FS, 20 bez anamn\u00E9zy FS). U v\u0161ech pacient\u016F za\u010Dlen\u011Bn\u00FDch do studie byl k dispozici EKG z\u00E1znam. Makroskopicky byla hodnocena p\u0159edev\u0161\u00EDm hmotnost srdce a velikost lev\u00E9 s\u00EDn\u011B (LS). Histologicky bylo vy\u0161et\u0159eno 7 standardizovan\u00FDch lokalit z obou srde\u010Dn\u00EDch s\u00EDn\u00ED. Ve v\u0161ech vzorc\u00EDch byla hodnocena t\u00ED\u017Ee jizven\u00ED a rozsah depozice izolovan\u00E9ho s\u00ED\u0148ov\u00E9ho amyloidu (IAA). Na EKG z\u00E1znamech byla hodnocena P vlna. Nepoda\u0159ilo se prok\u00E1zat v\u00FDznamn\u00FD rozd\u00EDl v charakteristik\u00E1ch P vlny mezi pacienty s a bez anamn\u00E9zy FS. Morfologicky m\u011Bli pacienti s FS ve srovn\u00E1n\u00ED s kontroln\u00ED skupinou signifikantn\u011B t\u011B\u017E\u0161\u00ED srdce, s objemn\u011Bj\u0161\u00ED LS, s v\u00FDrazn\u011Bji zjizvenou svalovinou LS a mezis\u00ED\u0148ov\u00E9ho septa a se z\u00E1va\u017En\u011Bj\u0161\u00EDm posti\u017Een\u00EDm obou s\u00EDn\u00ED amyloid\u00F3zou. Distribuce fibr\u00F3zy i depozit IAA byla v jednotliv\u00FDch odd\u00EDlech srde\u010Dn\u00EDch s\u00EDn\u00ED nerovnom\u011Brn\u00E1. V LS byla nejt\u011B\u017E\u0161\u00ED fibr\u00F3za u pacient\u016F s FS v oblasti stropu, nejv\u00FDrazn\u011Bj\u0161\u00ED amyloid\u00F3za v oblasti p\u0159edn\u00ED st\u011Bny. V obou skupin\u00E1ch byla v\u00FDrazn\u011Bj\u0161\u00ED amyloid\u00F3za v lev\u00E9 s\u00EDni ne\u017Eli v prav\u00E9. Pozoruhodn\u00FDm n\u00E1lezem byla nep\u0159\u00EDtomnost IAA v sinoatri\u00E1ln\u00EDm uzlu p\u0159evodn\u00EDho syst\u00E9mu. Nesouvisl\u00E9 distribuce struktur\u00E1ln\u00EDch zm\u011Bn myokardu s\u00EDn\u00ED by bylo mo\u017En\u00E9 vyu\u017E\u00EDt k ur\u010Den\u00ED vhodn\u00E9ho m\u00EDsta pro odb\u011Br vzork\u016F k histologick\u00E9 diagnostice a p\u0159isp\u011Bt by mohla i kardiolog\u016Fm v terapii arytmi\u00ED, k lep\u0161\u00EDmu zac\u00EDlen\u00ED radiofrekven\u010Dn\u00ED ablace."@cs . . "CZ - \u010Cesk\u00E1 republika" . "\u0160teiner, Ivo" . "electrocardiographic features; myocardial scarring; isolated atrial amyloid; atrial fibrillation"@en . . "Morfologick\u00E9 a elektrofyziologick\u00E9 zm\u011Bny v srde\u010Dn\u00EDch s\u00EDn\u00EDch zem\u0159el\u00FDch s fibrilac\u00ED s\u00EDn\u00ED - pilotn\u00ED studie" . . . . . . "1210-7875" . "Morphological and electrophysiological changes of the heart atria in necropsy patients with atrial fibrillation - a pilot study"@en . "Morfologick\u00E9 a elektrofyziologick\u00E9 zm\u011Bny v srde\u010Dn\u00EDch s\u00EDn\u00EDch zem\u0159el\u00FDch s fibrilac\u00ED s\u00EDn\u00ED - pilotn\u00ED studie"@cs . "Morfologick\u00E9 a elektrofyziologick\u00E9 zm\u011Bny v srde\u010Dn\u00EDch s\u00EDn\u00EDch zem\u0159el\u00FDch s fibrilac\u00ED s\u00EDn\u00ED - pilotn\u00ED studie" . . "4" . "Atrial fibrillation (AF), the most common supraventricular tachycardia, has a morphological base, so called remodelation of atrial myocardium, with its abnormal conduction pattern as a consequence. The remodelation regards electrical, contractile, and structural properties. In this pilot study we attempted to find relations between the myocardial morphological (scarring, amyloidosis, left atrial enlargement) and electrophysiological (ECG characteristics of the P-wave) changes in patients with AF. We examined 40 hearts of necropsy patients - 20 with a history of AF and 20 with no history of AF. Grossly, the heart weight and the size of the left atrium (LA) were evaluated. Histologically, 7 standard sites from the atria were examined. In each specimen, the degree of myocardial scarring and of deposition of isolated atrial amyloid (IAA) were assessed. We failed to show any significant difference in the P-wave pattern between patients with and without AF. Morphologically, however, there were several differences - the patients with AF had significantly heavier hearts, larger left atria, more severely scarred myocardium of the LA and the atrial septum, and more severe deposition of IAA in both atria in comparison to the control group of patients with sinus rhythm. The left atrial distribution of both fibrosis and amyloidosis was irregular. In patients with AF the former was most pronounced in the LA ceiling while the latter in the LA anterior wall. The entire series showed more marked amyloidosis in the left than in the right atrium. An interesting finding was the universal absence of IAA in the sinoatrial node. The knowledge of distribution of atrial myocardial structural changes could be utilized by pathologists in taking specimens for histology and also by cardiologists in targeting the radiofrequency ablation therapy."@en . . . . . "30536" . . "RIV/00216208:11150/14:10283646" . "Mat\u011Bjkov\u00E1, Ad\u00E9la" . "50-59" . "11150" . "[48C2BDC3FBDA]" . . .