"Effect of collagen I gel on apoptosis of rat hepatic stellate cells"@en . "71417" . "Activated hepatic stellate cells (HSC) are a major source of fibrous proteins in cirrhotic liver. Inducing or accelerating their apoptosis is a potential way of liver fibrosis treatment. Extracellular matrix (ECM) surrounding cells in tissue affects their differentiation, migration, proliferation and function. Type I collagen is the main ECM component in fibrotic liver. We have examined how this protein modifies apoptosis of normal rat HSC induced by gliotoxin, cycloheximide and cytochalasin D in vitro and spontaneous apoptosis of HSC isolated from CCl4-damaged liver. We have found that type I collagen gel enhances HSC apoptosis regardless of the agent triggering this process."@en . . "RIV/00216208:11150/13:10173959!RIV14-MSM-11150___" . . "CZ - \u010Cesk\u00E1 republika" . . "56" . "Jiroutov\u00E1, Alena" . . "7"^^ . . . "Effect of collagen I gel on apoptosis of rat hepatic stellate cells" . . "Cytochalasin D; Cykloheximide; Gliotoxin; Apoptosis; Collagen I; Hepatic stellate cells"@en . "1211-4286" . . "Effect of collagen I gel on apoptosis of rat hepatic stellate cells"@en . . "Bittnerov\u00E1, Lenka" . . . . . "Rudolf, Emil" . "Acta Medica (Hradec Kr\u00E1lov\u00E9)" . "2" . . . . "11150" . . "[63BA2686EDBF]" . "I" . "Kanta, Ji\u0159\u00ED" . . "Effect of collagen I gel on apoptosis of rat hepatic stellate cells" . . "5"^^ . "Activated hepatic stellate cells (HSC) are a major source of fibrous proteins in cirrhotic liver. Inducing or accelerating their apoptosis is a potential way of liver fibrosis treatment. Extracellular matrix (ECM) surrounding cells in tissue affects their differentiation, migration, proliferation and function. Type I collagen is the main ECM component in fibrotic liver. We have examined how this protein modifies apoptosis of normal rat HSC induced by gliotoxin, cycloheximide and cytochalasin D in vitro and spontaneous apoptosis of HSC isolated from CCl4-damaged liver. We have found that type I collagen gel enhances HSC apoptosis regardless of the agent triggering this process." . "5"^^ . . . "\u0158ez\u00E1\u010Dov\u00E1, Martina" . . "RIV/00216208:11150/13:10173959" .