"Mu\u017Esk\u00FD hypogonadismus a diabetes mellitus"@cs . . "Male hypogonadism and diabetes mellitus"@en . . "Mu\u017Esk\u00FD hypogonadismus a diabetes mellitus" . "1212-4184" . . "RIV/00216208:11150/13:10173652!RIV14-MSM-11150___" . "1"^^ . "90277" . . "1"^^ . "I" . "Low testosterone level is common in men with metabolic syndrome and it occurs even more frequently if the man suffers from type 2 diabetes at the same time. In its pathogenesis, an important role is played by increased levels of inflammation mediators, and also by insulin and leptin resistance and inhibitory effects of leptin on Leydig cells. A routine examination of testosterone levels is indicated in every man with type 2 diabetes mellitus. Low testosterone level may manifest by decreased libido, erectile dysfunction, fatigue and depressive moods. Testosterone substitution therapy is indicated only in patients with symptoms of hypogonadism. The therapy primarily improves libido, erectile dysfunction tends to be less affected. Metabolic changes during testosterone substitution are insignificant and they are not an indication for therapy. Risks of testosterone replacement therapy are few; it is necessary to monitor prostate health and haematocrit. The follow-up examinations should be standardised."@en . . "15" . . . "Postgradu\u00E1ln\u00ED medic\u00EDna" . "Male hypogonadism and diabetes mellitus"@en . "\u010C\u00E1p, Jan" . . "4" . "CZ - \u010Cesk\u00E1 republika" . "Mu\u017Esk\u00FD hypogonadismus a diabetes mellitus"@cs . "RIV/00216208:11150/13:10173652" . "N\u00EDzk\u00E1 hladina testosteronu je \u010Dasto p\u0159\u00EDtomna u mu\u017E\u016F s metabolick\u00FDm syndromem a je\u0161t\u011B \u010Dast\u011Bj\u0161\u00ED je p\u0159i sou\u010Dasn\u00E9 p\u0159\u00EDtomnosti diabetu 2. typu. V patogenezi hraje d\u016Fle\u017Eitou roli vzestup medi\u00E1tor\u016F z\u00E1n\u011Btu, rezistence k \u00FA\u010Dinku inzul\u00EDnu a leptinu a inhibi\u010Dn\u00ED \u00FA\u010Dinek leptinu na Leydigovy bu\u0148ky. Vy\u0161et\u0159en\u00ED hladiny testosteronu je indikov\u00E1no u v\u0161ech mu\u017E\u016F s diabetem 2. typu. N\u00EDzk\u00E1 hladina testosteronu se m\u016F\u017Ee projevit sn\u00ED\u017Een\u00EDm libida, erektiln\u00ED dysfunkc\u00ED, \u00FAnavnost\u00ED a depresivn\u00EDm lad\u011Bn\u00EDm, pod\u00EDl\u00ED se na vzniku an\u00E9mie, osteopor\u00F3zy, zhor\u0161uje inzul\u00EDnovou rezistenci. Substituce je indikov\u00E1na jen tam, kde jsou p\u0159\u00EDtomny klinick\u00E9 p\u0159\u00EDznaky hypogonadismu. Substituce zlep\u0161uje p\u0159edev\u0161\u00EDm libido, m\u00E9n\u011B poruchy erekce. Metabolick\u00E9 \u00FA\u010Dinky jsou p\u0159i substituci mal\u00E9 a nejsou indikac\u00ED k terapii. Rizika substituce nejsou velk\u00E1, sledovat je nutno onemocn\u011Bn\u00ED prostaty a hematokrit. Sledov\u00E1n\u00ED nemocn\u00FDch se substituc\u00ED by m\u011Blo b\u00FDt standardizov\u00E1no."@cs . "7"^^ . . . "substitution; metabolic syndrome; type 2 diabetes mellitus; testosterone"@en . . . "N\u00EDzk\u00E1 hladina testosteronu je \u010Dasto p\u0159\u00EDtomna u mu\u017E\u016F s metabolick\u00FDm syndromem a je\u0161t\u011B \u010Dast\u011Bj\u0161\u00ED je p\u0159i sou\u010Dasn\u00E9 p\u0159\u00EDtomnosti diabetu 2. typu. V patogenezi hraje d\u016Fle\u017Eitou roli vzestup medi\u00E1tor\u016F z\u00E1n\u011Btu, rezistence k \u00FA\u010Dinku inzul\u00EDnu a leptinu a inhibi\u010Dn\u00ED \u00FA\u010Dinek leptinu na Leydigovy bu\u0148ky. Vy\u0161et\u0159en\u00ED hladiny testosteronu je indikov\u00E1no u v\u0161ech mu\u017E\u016F s diabetem 2. typu. N\u00EDzk\u00E1 hladina testosteronu se m\u016F\u017Ee projevit sn\u00ED\u017Een\u00EDm libida, erektiln\u00ED dysfunkc\u00ED, \u00FAnavnost\u00ED a depresivn\u00EDm lad\u011Bn\u00EDm, pod\u00EDl\u00ED se na vzniku an\u00E9mie, osteopor\u00F3zy, zhor\u0161uje inzul\u00EDnovou rezistenci. Substituce je indikov\u00E1na jen tam, kde jsou p\u0159\u00EDtomny klinick\u00E9 p\u0159\u00EDznaky hypogonadismu. Substituce zlep\u0161uje p\u0159edev\u0161\u00EDm libido, m\u00E9n\u011B poruchy erekce. Metabolick\u00E9 \u00FA\u010Dinky jsou p\u0159i substituci mal\u00E9 a nejsou indikac\u00ED k terapii. Rizika substituce nejsou velk\u00E1, sledovat je nutno onemocn\u011Bn\u00ED prostaty a hematokrit. Sledov\u00E1n\u00ED nemocn\u00FDch se substituc\u00ED by m\u011Blo b\u00FDt standardizov\u00E1no." . "Mu\u017Esk\u00FD hypogonadismus a diabetes mellitus" . . "11150" . . "[2CFA6D4D1E55]" . . .