"Ot\u00E1zka soub\u011B\u017En\u00E9ho pod\u00E1v\u00E1n\u00ED inhibitor\u016F protonov\u00E9 pumpy a Klopidogrelu je st\u00E1le \u010Dast\u011Bji diskutov\u00E1na odbornou ve\u0159ejnost\u00ED. Sou\u010Dasn\u00E9 pod\u00E1n\u00ED t\u011Bchto l\u00E9k\u016F se vyskytuje v klinick\u00E9 praxi pom\u011Brn\u011B \u010Dasto. N\u011Bkter\u00E9 retrospektivn\u00ED a observa\u010Dn\u00ED studie nazna\u010Duj\u00ED potenci\u00E1ln\u00ED interakci mezi PPI a Klopidogrelem, kter\u00E1 by mohla v\u00E9st ke sn\u00ED\u017Een\u00ED antiagrega\u010Dn\u00ED aktivity Klopidogrelu a tedy ke zv\u00FD\u0161en\u00ED incidence trombotick\u00FDch p\u0159\u00EDhod. Celkov\u011B v\u0161ak nelze spolehliv\u011B posoudit, zda pozorovan\u00E9 souvislosti jsou projevem ne\u017E\u00E1douc\u00EDch interakc\u00ED, nep\u0159\u00EDm\u00FDch souvislost\u00ED, nebo jen n\u00E1hodn\u00FDm jevem. Z jedin\u00E9 v sou\u010Dasn\u00E9 dob\u011B dostupn\u00E9 randomizovan\u00E9 prospektivn\u00ED studie, kter\u00E1 v\u0161ak byla p\u0159ed\u010Dasn\u011B ukon\u010Dena, nebyl potvrzen vy\u0161\u0161\u00ED v\u00FDskyt kardiovaskul\u00E1rn\u00EDch p\u0159\u00EDhod ani n\u00E1sledn\u00FDch revaskularizac\u00ED."@cs . "Klopidogrel a inhibitory protonov\u00E9 pumpy" . "Klep\u00E1\u010Dkov\u00E1, Helena" . . . "Bure\u0161, Jan" . . "CZ - \u010Cesk\u00E1 republika" . "Ot\u00E1zka soub\u011B\u017En\u00E9ho pod\u00E1v\u00E1n\u00ED inhibitor\u016F protonov\u00E9 pumpy a Klopidogrelu je st\u00E1le \u010Dast\u011Bji diskutov\u00E1na odbornou ve\u0159ejnost\u00ED. Sou\u010Dasn\u00E9 pod\u00E1n\u00ED t\u011Bchto l\u00E9k\u016F se vyskytuje v klinick\u00E9 praxi pom\u011Brn\u011B \u010Dasto. N\u011Bkter\u00E9 retrospektivn\u00ED a observa\u010Dn\u00ED studie nazna\u010Duj\u00ED potenci\u00E1ln\u00ED interakci mezi PPI a Klopidogrelem, kter\u00E1 by mohla v\u00E9st ke sn\u00ED\u017Een\u00ED antiagrega\u010Dn\u00ED aktivity Klopidogrelu a tedy ke zv\u00FD\u0161en\u00ED incidence trombotick\u00FDch p\u0159\u00EDhod. Celkov\u011B v\u0161ak nelze spolehliv\u011B posoudit, zda pozorovan\u00E9 souvislosti jsou projevem ne\u017E\u00E1douc\u00EDch interakc\u00ED, nep\u0159\u00EDm\u00FDch souvislost\u00ED, nebo jen n\u00E1hodn\u00FDm jevem. Z jedin\u00E9 v sou\u010Dasn\u00E9 dob\u011B dostupn\u00E9 randomizovan\u00E9 prospektivn\u00ED studie, kter\u00E1 v\u0161ak byla p\u0159ed\u010Dasn\u011B ukon\u010Dena, nebyl potvrzen vy\u0161\u0161\u00ED v\u00FDskyt kardiovaskul\u00E1rn\u00EDch p\u0159\u00EDhod ani n\u00E1sledn\u00FDch revaskularizac\u00ED." . "321873" . "3"^^ . "Clopidogrel and proton pump inhibitors"@en . "11150" . . "7" . "Clopidogrel and proton pump inhibitors"@en . "Klopidogrel a inhibitory protonov\u00E9 pumpy" . . "The question of concurrent administration of proton pump inhibitors and clopidogrel is increasingly discussed by the professional community. Co-administration of these drugs occurs in clinical practice quite often. Several retrospective and observational studies suggest a potential interaction between clopidogrel and PPI, which would lead to a reduction of the antiplatelet activity of clopidogrel and therefore to an increasing of the incidence of thrombotic events. Overall, we can not reliably assess whether the observed relations are a manifestation of adverse interactions, indirect connections, or just a random phenomenon. From the only currently available randomized prospective study, which has been prematurely terminated, was not confirmed a higher incidence of cardiovascular events or subsequent revascularisation."@en . . "RIV/00216208:11150/09:00208862!RIV10-MZ0-11150___" . . "[94C96A499162]" . . . "Clopidogrel; proton pumps inhibitors; drug interactions; platelet aggregability"@en . . "Folia Gastroenterologica et Hepatologica" . "Klopidogrel a inhibitory protonov\u00E9 pumpy"@cs . "3-4" . . . "Z(MZ0FNHK2005)" . . "1214-4088" . "3"^^ . "Sola\u0159, Miroslav" . . . "Klopidogrel a inhibitory protonov\u00E9 pumpy"@cs . . . "RIV/00216208:11150/09:00208862" . "2"^^ .