"Cholesterol je z\u00E1kladn\u00ED slo\u017Eka bun\u011B\u010Dn\u00FDch membr\u00E1n, je prekurzorem v tvorb\u011B steroidn\u00EDch hormon\u016F, \u017Elu\u010Dov\u00FDch kyselin a dal\u0161\u00EDch pro \u017Eivot d\u016Fle\u017Eit\u00FDch slo\u017Eek. Synt\u00E9za cholesterolu je komplikovan\u00FD energeticky n\u00E1ro\u010Dn\u00FD proces. Nen\u00ED zn\u00E1mo, jak\u00E1 je denn\u00ED pot\u0159eba cholesterolu a jak\u00FDm mechanismem doch\u00E1z\u00ED k jeho poklesu cholesterolu u kriticky nemocn\u00FDch. Byl nalezen signifikantn\u00ED pokles cholesterolu b\u011Bhem stresov\u00E9 situace. Hypocholesterolemie je zn\u00E1ma \u0159adu let a je signifikantn\u011B spojena se zv\u00FD\u0161enou morbiditou a mortalitou. C\u00EDlem \u010Dl\u00E1nku je oz\u0159ejmen\u00ED role a v\u00FDznamu cholesterolu b\u011Bhem intenzivn\u00ED p\u00E9\u010De."@cs . "2" . "11150" . "000262332100001" . "Cholesterol is an essential component of cell membranes, precursor of steroids, biliary acids and other components of serious importance in live organism. Cholesterol synthesis is a complicated and energy-demanding process. Real daily need of cholesterol and mechanisms of decline cholesterol levels in critical ill are unknown. During stressfull situations a significant hypocholesterolaemia may be found. Hypocholesterolemia has been known for a number of years to be a significant prognostic indicator of increased morbidity and mortality connected with a whole spectrum of pathological conditions. The aim of article is the elucidation of the role and importance of hypocholesterolaemia during the intensive care. ."@en . . . "Chiarla, Carlo" . "Tich\u00E1, Alena" . . "Hypocholesterolemie v klinicky z\u00E1va\u017En\u00FDch stavech"@cs . . "Hrn\u010Diarikov\u00E1, Dana" . . "Hypocholesterolemia in clinically serious conditions - review"@en . "cholesterol; hypocholesterolemia; hypolipoproteinemia; SIRS; cytokines; polytrauma; sepsis; critically ill"@en . . . "Giovannini, Ivo" . . . "RIV/00216208:11150/08:00106551" . . . "Hypocholesterolemie v klinicky z\u00E1va\u017En\u00FDch stavech"@cs . "Hypocholesterolemia in clinically serious conditions - review" . "7"^^ . "Hypocholesterolemia in clinically serious conditions - review"@en . . . "371112" . "Biomedical Papers of the Faculty of Medicine of Palacky University" . "Zad\u00E1k, Zden\u011Bk" . "RIV/00216208:11150/08:00106551!RIV09-MZ0-11150___" . . . "P(NR8921)" . . . "[2B4338F45518]" . "1213-8118" . . "3"^^ . . . . "Cholesterol is an essential component of cell membranes, precursor of steroids, biliary acids and other components of serious importance in live organism. Cholesterol synthesis is a complicated and energy-demanding process. Real daily need of cholesterol and mechanisms of decline cholesterol levels in critical ill are unknown. During stressfull situations a significant hypocholesterolaemia may be found. Hypocholesterolemia has been known for a number of years to be a significant prognostic indicator of increased morbidity and mortality connected with a whole spectrum of pathological conditions. The aim of article is the elucidation of the role and importance of hypocholesterolaemia during the intensive care. ." . "Hy\u0161pler, Radom\u00EDr" . "Vyroubal, Pavel" . "Hypocholesterolemia in clinically serious conditions - review" . "9"^^ . . "CZ - \u010Cesk\u00E1 republika" . "152" .