"Zinc has been shown to have inhibitory effects on proliferation and metabolism of malignant colonocytes. Still, there is no information available concerning putative effects of zinc against motility and migration of colon cancer cells. Using fluorescence microscopy, immunoblotting and microfluorimetry we show that treatment with zinc sulfate affected motility, invasiveness, cytoskeletal integrity and expression of selected markers (E-cadherin, catenin, vimentin, tubulin and actin) of invasive SW480 colon tumor cells. These results emphasize the possible multitudinous role of zinc in the process of colon cancer development and hint at the potential of this element in chemoprevention of advanced colorectal carcinoma." . "1211-4286" . "Zinek ovliv\u0148je integritu a migraci n\u00E1dorov\u00FDch bun\u011Bk kolorekta"@cs . . . . "1" . "4"^^ . "John, Stanislav" . . . . "Zinc has been shown to have inhibitory effects on proliferation and metabolism of malignant colonocytes. Still, there is no information available concerning putative effects of zinc against motility and migration of colon cancer cells. Using fluorescence microscopy, immunoblotting and microfluorimetry we show that treatment with zinc sulfate affected motility, invasiveness, cytoskeletal integrity and expression of selected markers (E-cadherin, catenin, vimentin, tubulin and actin) of invasive SW480 colon tumor cells. These results emphasize the possible multitudinous role of zinc in the process of colon cancer development and hint at the potential of this element in chemoprevention of advanced colorectal carcinoma."@en . "Z(MSM0021620820)" . "Zinc alters cytoskeletal integrity and migration in colon cancer cells"@en . "Zinc alters cytoskeletal integrity and migration in colon cancer cells" . "Klva\u010Dov\u00E1, Lada" . "2"^^ . . "RIV/00216208:11150/08:00106537!RIV09-MSM-11150___" . "[EEFEF3F7BBC6]" . "51" . "11150" . "Zinc alters cytoskeletal integrity and migration in colon cancer cells"@en . . "CZ - \u010Cesk\u00E1 republika" . . "Zinc alters cytoskeletal integrity and migration in colon cancer cells" . . "7"^^ . . "Zinek ovliv\u0148je integritu a migraci n\u00E1dorov\u00FDch bun\u011Bk kolorekta"@cs . "Rudolf, Emil" . "406815" . . . "Acta Medica (Hradec Kr\u00E1lov\u00E9)" . "SW480 cells; migration; invasion; cytoskeleton; microtubules"@en . "RIV/00216208:11150/08:00106537" . "Bylo prok\u00E1z\u00E1no, \u017Ee zinek m\u00E1 inhibi\u010Dn\u00ED \u00FA\u010Dinky na proliferaci a metabolismus malign\u00EDch kolonocyt\u016F. I p\u0159esto neexistuj\u00ED informace o jeho \u00FA\u010Dinc\u00EDch na motilitu a migraci t\u011Bchto bun\u011Bk. Za pomoci fluorescen\u010Dn\u00ED mikroskopie imunoblotingu a mikroflurometrie dokazujeme, \u017Ee s\u00EDran zine\u010Dnat\u00FD ovliv\u0148uje motilitu, invazivitu, integritu cytoskeletu a expresi vybran\u00FDch marker\u016F (E-kadherin, katenin, vimentin, tubulin a aktin) u invazivn\u00EDch bun\u011Bk linie SW480. Tyto v\u00FDsledky podtrhuj\u00ED mo\u017Enou flexibiln\u00ED \u00FAlohu zinku v procesu kolorekt\u00E1ln\u00ED karcinogeneze a nazna\u010Duj\u00ED chemopreventivn\u00ED potenci\u00E1l tohoto prvku u rozvinut\u00E9ho kolorekt\u00E1ln\u00EDho karcinomu."@cs . . . . . . "\u010Cervinka, Miroslav" .