. "Re\u0161l, Milan" . "[9BA7B4CB436A]" . "Mutace v genu pro beta katenin vedou k jeho akumulaci a aberantn\u00ED lokalizaci v bu\u0148k\u00E1ch (j\u00E1dro/cytoplazma). Ned\u00E1vno jsme prok\u00E1zali specifickou lokalizaci mutovan\u00E9ho beta-kateninu u m\u00E1lo diferencovan\u00E9ho adenokarcinomu typu fet\u00E1ln\u00EDch plic (L-FLAC) a epiteli\u00E1ln\u00EDho prototypu klasick\u00E9ho pulmon\u00E1ln\u00EDho blastomu (CPB) - dob\u0159e diferencovan\u00E9ho adenokarcinomu (WDFA). Beta-katenin jsme nyn\u00ED studovali u 9 n\u00E1dor\u016F plic, kter\u00E9 byly histologicky definov\u00E1ny jako CPB a blastomatoidn\u00ED varianty karcinosarkomu (BCS). V\u0161echny CPB vykazovaly aberantn\u00ED lokalizaci kateninu, kde\u017Eto BCS vykazovaly minim\u00E1ln\u00ED aberantn\u00ED lokalizaci tohoto proteinu. Muta\u010Dn\u00ED anal\u00FDza exonu 3 genu pro beta katenin prok\u00E1zala, \u017Ee 3 CPB se vyzna\u010Dovaly missense mutacemi (S29F, S37F, S37F), kter\u00E9 chyb\u011Bly u BCS. Tyto v\u00FDsledky ukazuj\u00ED odli\u0161nosti mezi CPB a BCS a poukazuj\u00ED na vhodnost imunodetekce beta kateninu pro odli\u0161en\u00ED t\u011Bchto n\u00E1dor\u016F."@cs . . . "11150" . . . "921;927" . "Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma - beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma" . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "7"^^ . "We studied 9 lung tumors previously diagnosed as biphasic pulmonary blastoma (PB). This study suggests that beta-catenin gene mutations may play a role in the tumorigenesis of CPB. Although CPB and BCS have often been grouped together as biphasic PB, they are different entities based on immunohistochemical and molecular analysis of beta-catenin. Immunostaining for beta-catenin is useful for the discrimination."@en . . "RIV/00216208:11150/07:00004246!RIV08-MSM-11150___" . "American Journal of Surgical Pathology" . . . "19"^^ . "Aberantn\u00ED jadern\u00E1/cytoplasmatick\u00E1 lokalizace a genov\u00E9 mutace beta-cateninu u klasick\u00E9ho pulmon\u00E1ln\u00EDho blastomu - imunohistochem. detekce beta-cateninu je u\u017Eite\u010Dn\u00E1 pro rozli\u0161en\u00ED mezi klasick\u00FDm pulmon\u00E1ln\u00EDm blastomem a blastomatoidn\u00ED variantou karcinosarcomu"@cs . "28" . "RIV/00216208:11150/07:00004246" . . . . . . "S" . . "Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma - beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma" . . "7" . . "0147-5185" . . "Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma - beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma"@en . . . . "1"^^ . "We studied 9 lung tumors previously diagnosed as biphasic pulmonary blastoma (PB). This study suggests that beta-catenin gene mutations may play a role in the tumorigenesis of CPB. Although CPB and BCS have often been grouped together as biphasic PB, they are different entities based on immunohistochemical and molecular analysis of beta-catenin. Immunostaining for beta-catenin is useful for the discrimination." . "Aberantn\u00ED jadern\u00E1/cytoplasmatick\u00E1 lokalizace a genov\u00E9 mutace beta-cateninu u klasick\u00E9ho pulmon\u00E1ln\u00EDho blastomu - imunohistochem. detekce beta-cateninu je u\u017Eite\u010Dn\u00E1 pro rozli\u0161en\u00ED mezi klasick\u00FDm pulmon\u00E1ln\u00EDm blastomem a blastomatoidn\u00ED variantou karcinosarcomu"@cs . . "408297" . "Aberrant; nuclear/cytoplasmic; localization; mutation; beta-catenin; classic; pulmonary; blastoma; beta-catenin; immunostaining; useful; distinguishing; between; classic; pulmonary; blastoma; blastomatoid; variant; carcinosarcoma"@en . . . . "Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma - beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma"@en .