. "Vliv antiepileptik na homeost\u00E1zu hormon\u016F \u0161t\u00EDtn\u00E9 \u017El\u00E1zy" . "1210-7859" . . "Vliv antiepileptik na homeost\u00E1zu hormon\u016F \u0161t\u00EDtn\u00E9 \u017El\u00E1zy"@cs . "RIV/00216208:11150/07:00004104!RIV08-MSM-11150___" . "Vliv antiepileptik na homeost\u00E1zu hormon\u016F \u0161t\u00EDtn\u00E9 \u017El\u00E1zy" . "The effect of antiepileptic drugs on thyroid hormone homeostasis"@en . . "5" . "11150" . . "The effect of antiepileptic drugs on thyroid hormone homeostasis"@en . "1"^^ . . "S" . . "2"^^ . . . "Diskuse o vlivu antiepileptik (AE) na homeost\u00E1zu hormon\u016F \u0161t\u00EDtn\u00E9 \u017El\u00E1zy (\u0160\u017D) za\u010Dala na po\u010D\u00E1tku 60. let 20. stolet\u00ED. Ukazuje se, \u017Ee pouze AE, kter\u00E1 pat\u0159\u00ED mezi enzymatick\u00E9 induktory (AE-IND), jmenovit\u011B fenobarbital, primidon, fenytoin, karbamazepin a oxkarbazepin, maj\u00ED charakteristick\u00FD vliv na homeost\u00E1zu hormon\u016F \u0160\u017D, kter\u00FD spo\u010D\u00EDv\u00E1 v poklesu jejich hladin. Nemocn\u00ED, kte\u0159\u00ED nejsou l\u00E9\u010Deni pro onemocn\u011Bn\u00ED \u0160\u017D, z\u016Fst\u00E1vaj\u00ED b\u011Bhem medikace AE-IND eutyroidn\u00ED a nevy\u017Eaduj\u00ED T4-substitu\u010Dn\u00ED l\u00E9\u010Dbu. Nemocn\u00ED s hypofunk\u010Dn\u00ED/afunk\u010Dn\u00ED \u0160\u017D jsou po expozici AE-IND ohro\u017Eeni v\u00FDznamn\u00FDm rizikem dekompenzace hypotyre\u00F3zy mechanizmem farmakokinetick\u00E9 interakce AE-IND s T4(T3) substitu\u010Dn\u00ED terapi\u00ED. Maximum tohoto rizika lze o\u010Dek\u00E1vat p\u0159ibli\u017En\u011B v obdob\u00ED prvn\u00EDch 2 m\u011Bs\u00EDc\u016F po zah\u00E1jen\u00ED medikace AE-IND; jsou zm\u00EDn\u011Bna specifika klinick\u00E9ho p\u0159\u00EDstupu k t\u011Bmto nemocn\u00FDm. V p\u0159\u00EDpad\u011B ostatn\u00EDch antiepileptik je vliv na homeost\u00E1zu hormon\u016F \u0160\u017D nev\u00FDrazn\u00FD, pop\u0159\u00EDpad\u011B pr\u00E1ce na toto t\u00E9ma chyb\u00ED, \u010Di jsou pouze ve form\u011B kazuistick\u00FDch sd\u011Blen\u00ED." . "Diskuse o vlivu antiepileptik (AE) na homeost\u00E1zu hormon\u016F \u0161t\u00EDtn\u00E9 \u017El\u00E1zy (\u0160\u017D) za\u010Dala na po\u010D\u00E1tku 60. let 20. stolet\u00ED. Ukazuje se, \u017Ee pouze AE, kter\u00E1 pat\u0159\u00ED mezi enzymatick\u00E9 induktory (AE-IND), jmenovit\u011B fenobarbital, primidon, fenytoin, karbamazepin a oxkarbazepin, maj\u00ED charakteristick\u00FD vliv na homeost\u00E1zu hormon\u016F \u0160\u017D, kter\u00FD spo\u010D\u00EDv\u00E1 v poklesu jejich hladin. Nemocn\u00ED, kte\u0159\u00ED nejsou l\u00E9\u010Deni pro onemocn\u011Bn\u00ED \u0160\u017D, z\u016Fst\u00E1vaj\u00ED b\u011Bhem medikace AE-IND eutyroidn\u00ED a nevy\u017Eaduj\u00ED T4-substitu\u010Dn\u00ED l\u00E9\u010Dbu. Nemocn\u00ED s hypofunk\u010Dn\u00ED/afunk\u010Dn\u00ED \u0160\u017D jsou po expozici AE-IND ohro\u017Eeni v\u00FDznamn\u00FDm rizikem dekompenzace hypotyre\u00F3zy mechanizmem farmakokinetick\u00E9 interakce AE-IND s T4(T3) substitu\u010Dn\u00ED terapi\u00ED. Maximum tohoto rizika lze o\u010Dek\u00E1vat p\u0159ibli\u017En\u011B v obdob\u00ED prvn\u00EDch 2 m\u011Bs\u00EDc\u016F po zah\u00E1jen\u00ED medikace AE-IND; jsou zm\u00EDn\u011Bna specifika klinick\u00E9ho p\u0159\u00EDstupu k t\u011Bmto nemocn\u00FDm. V p\u0159\u00EDpad\u011B ostatn\u00EDch antiepileptik je vliv na homeost\u00E1zu hormon\u016F \u0160\u017D nev\u00FDrazn\u00FD, pop\u0159\u00EDpad\u011B pr\u00E1ce na toto t\u00E9ma chyb\u00ED, \u010Di jsou pouze ve form\u011B kazuistick\u00FDch sd\u011Blen\u00ED."@cs . . "Vliv antiepileptik na homeost\u00E1zu hormon\u016F \u0161t\u00EDtn\u00E9 \u017El\u00E1zy"@cs . "effect; antiepileptic; drugs; thyroid; hormone; homeostasis"@en . . . . "RIV/00216208:11150/07:00004104" . "\u010Cesk\u00E1 a slovensk\u00E1 neurologie a neurochirurgie" . "Discussion on antiepileptics (AE) influences on thyroid gland (TG) hormone homeostasis began in the 1960s. It appears that only the AE classified as enzymatic inductors (AE-IND), namely phenobarbital, primidone, phenytoin, carbamazepine and oxcarbazepine have characteristic level lowering influence on the homeostasis. Patients that are not treated for TG disorder remain euthyroidic during medication by AE-IND, and do not need T4-substitution treatment. Patients with hypofunction/afunction of TG are, after exposure to AE-IND, threatened by high risk of decompensation of the hypothyroidism due to the pharmacokinetic interaction of AE-IND with T4 (T) substitution therapy, especially in the period of the first 2 months after starting AE-IND medication. A necessary, specific approach to these patients is mentioned. The influence of other antiepileptics on the homeostasis of TG hormones is indefinite. There is either no relevant study in literature or the problems are described merely as case reports."@en . . "488;493" . . . "[8BA024710B0B]" . "Hor\u00E1\u010Dek, Ji\u0159\u00ED" . "70-103" . "CZ - \u010Cesk\u00E1 republika" . "458176" . "6"^^ . . .