"S2" . "[B5D9E4867C94]" . . . "Laboratorn\u00ED pr\u016Fkaz monoklon\u00E1ln\u00EDch imunoglobulin\u016F"@cs . . . "482807" . "CZ - \u010Cesk\u00E1 republika" . "0042-773X" . "Laboratorn\u00ED pr\u016Fkaz monoklon\u00E1ln\u00EDch imunoglobulin\u016F"@cs . . "RIV/00216208:11150/06:00005149!RIV08-MSM-11150___" . "5"^^ . . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . . . "Laboratory determination of monoclonal immunoglobulin"@en . . "The study takes a brief look at the methods currently being used, discussing their significance, the problems faced in their definition and interpretation. Among the primary clinical-biochemical methods, there are agarose electrophoresis and capillary electrophoresis. Immunofixation electrophoresis has completely replaced immunoelectrophoresis in determining immunoglobin classes and antigen types of paraprotein light chains. Immunofixation is more sensitive and quicker. The determining of the concentration of free light chains (non-secretory myeloma, AL amyloidosis, illness from light chains) has also found its place in the algorithm of laboratory methods used in monoclonal gammopathy. Out of the many prognostic factors, the combination \u00DF2-microglobulin and albumin has been chosen as the easiest and the one with the highest informative value. The spectrum of laboratory examinations is completed by determining the viscosity of serum and identification of cryoglobulins."@en . "Maisnar, Vladim\u00EDr" . . "V posledn\u00EDm desetilet\u00ED u\u010Dinila laboratorn\u00ED diagnostika monoklon\u00E1ln\u00EDch gammopati\u00ED obrovsk\u00FD krok kup\u0159edu. Studie pod\u00E1v\u00E1 stru\u010Dn\u00FD pohled na metody, kter\u00E9 jsou v sou\u010Dasn\u00E9 dob\u011B pou\u017E\u00EDv\u00E1ny, diskutuje jejich v\u00FDznam, probl\u00E9my, kter\u00FDm \u010Del\u00ED v definic\u00EDch a v\u00FDkladech. Mezi hlavn\u00ED klinick\u00E9 biochemick\u00E9 metody pat\u0159\u00ED agar\u00F3zn\u00ED elektrofor\u00E9za a kapil\u00E1rn\u00ED elektrofor\u00E9za. Elektrofor\u00E9zn\u00ED imunofixace zcela nahrazuje imunoelektrofor\u00E9zu p\u0159i ur\u010Dov\u00E1n\u00ED imunoglobinov\u00FDch t\u0159\u00EDd a typ\u016F antigenu paraproteinov\u00FDch sv\u011Bteln\u00FDch \u0159et\u011Bzc\u016F. Immunofixation je citliv\u011Bj\u0161\u00ED a rychlej\u0161\u00ED. Stanoven\u00ED koncentrace voln\u00FDch sv\u011Bteln\u00FDch \u0159et\u011Bzc\u016F (nevym\u011B\u0161ovac\u00ED myelom, AL amyloid\u00F3za, onemocn\u011Bn\u00ED ze sv\u011Bteln\u00FDch \u0159et\u011Bzc\u016F) tak\u00E9 na\u0161lo sv\u00E9 m\u00EDsto v algoritmu laboratorn\u00EDch metod pou\u017E\u00EDvan\u00FDch u monoklon\u00E1ln\u00ED gammopatie. Z mnoha prognostick\u00FDch faktor\u016F, kombinace \u00DF2-microglobulin a albuminu byla zvolena jako nejjednodu\u0161\u0161\u00ED a s nejvy\u0161\u0161\u00ED informa\u010Dn\u00ED hodnotu. Spektrum laboratorn\u00EDch vy\u0161et\u0159en\u00ED je dopln\u011Bno o stanoven\u00ED viskozity s\u00E9ra a identifikace kryoglobulin\u016F."@cs . "RIV/00216208:11150/06:00005149" . . . . "52" . . "2"^^ . "Laboratorn\u00ED pr\u016Fkaz monoklon\u00E1ln\u00EDch imunoglobulin\u016F" . "41;45" . "Laboratory determination of monoclonal immunoglobulin"@en . "Laboratory; determination; monoclonal; immunoglobulin"@en . "1"^^ . . "V posledn\u00EDm desetilet\u00ED u\u010Dinila laboratorn\u00ED diagnostika monoklon\u00E1ln\u00EDch gammopati\u00ED obrovsk\u00FD krok kup\u0159edu. Studie pod\u00E1v\u00E1 stru\u010Dn\u00FD pohled na metody, kter\u00E9 jsou v sou\u010Dasn\u00E9 dob\u011B pou\u017E\u00EDv\u00E1ny, diskutuje jejich v\u00FDznam, probl\u00E9my, kter\u00FDm \u010Del\u00ED v definic\u00EDch a v\u00FDkladech. Mezi hlavn\u00ED klinick\u00E9 biochemick\u00E9 metody pat\u0159\u00ED agar\u00F3zn\u00ED elektrofor\u00E9za a kapil\u00E1rn\u00ED elektrofor\u00E9za. Elektrofor\u00E9zn\u00ED imunofixace zcela nahrazuje imunoelektrofor\u00E9zu p\u0159i ur\u010Dov\u00E1n\u00ED imunoglobinov\u00FDch t\u0159\u00EDd a typ\u016F antigenu paraproteinov\u00FDch sv\u011Bteln\u00FDch \u0159et\u011Bzc\u016F. Immunofixation je citliv\u011Bj\u0161\u00ED a rychlej\u0161\u00ED. Stanoven\u00ED koncentrace voln\u00FDch sv\u011Bteln\u00FDch \u0159et\u011Bzc\u016F (nevym\u011B\u0161ovac\u00ED myelom, AL amyloid\u00F3za, onemocn\u011Bn\u00ED ze sv\u011Bteln\u00FDch \u0159et\u011Bzc\u016F) tak\u00E9 na\u0161lo sv\u00E9 m\u00EDsto v algoritmu laboratorn\u00EDch metod pou\u017E\u00EDvan\u00FDch u monoklon\u00E1ln\u00ED gammopatie. Z mnoha prognostick\u00FDch faktor\u016F, kombinace \u00DF2-microglobulin a albuminu byla zvolena jako nejjednodu\u0161\u0161\u00ED a s nejvy\u0161\u0161\u00ED informa\u010Dn\u00ED hodnotu. Spektrum laboratorn\u00EDch vy\u0161et\u0159en\u00ED je dopln\u011Bno o stanoven\u00ED viskozity s\u00E9ra a identifikace kryoglobulin\u016F." . "S, Z(MO0FVZ0000503)" . . "11150" . "Laboratorn\u00ED pr\u016Fkaz monoklon\u00E1ln\u00EDch imunoglobulin\u016F" . .