"Cytokine Tumor Necrosis Factor-alpha A Promoter Gene Polymorphism at Position - 308 G-->A and Pediatric Inflammatory Bowel Disease: Implications in Ulcerative Colitis and Crohn\u00B4s Disease"@cs . . . . . . "2"^^ . "Our pilot study aimed to determine the effect of tumor necrosis factor-alpha (TNF-alfa) 308 G?A promoter single-nucleotide polymorphism in pediatric inflammatory bowel disease (IBD), its influence on inflammatory activity and the clinical manifestations. METHODS: We obtained genomic DNA from 164 subjects, 82 with long-standing IBD aged 8 to 18 years: 46 with Crohn disease (CD) and 36 with ulcerative colitis (UC). CONCLUSIONS: Although not necessarily dictating IBD initiation, the TNF-alfa 308 A polymorphism may play a role in modifying the CD phenotype. The polymorphism may influence disease activity as well as more intense inflammatory activity in both forms of IBD and may modify the progression of chronic digestive tract inflammation." . . . "Journal of Pediatric Gastroenterology and Nutrition" . . "Cytokine Tumor Necrosis Factor-alpha A Promoter Gene Polymorphism at Position-308 G-->A and Pediatric Inflammatory Bowel Disease: Implications in Ulcerative Colitis and Crohn\u00B4s Disease" . . "Pozler, Old\u0159ich" . "470261" . . . "42" . . . "Cytokine Tumor Necrosis Factor-alpha A Promoter Gene Polymorphism at Position-308 G-->A and Pediatric Inflammatory Bowel Disease: Implications in Ulcerative Colitis and Crohn\u00B4s Disease"@en . "10"^^ . "Cytokine Tumor Necrosis Factor-alpha A Promoter Gene Polymorphism at Position - 308 G-->A and Pediatric Inflammatory Bowel Disease: Implications in Ulcerative Colitis and Crohn\u00B4s Disease"@cs . . "5" . "RIV/00216208:11150/06:00005147" . "Cytokine Tumor Necrosis Factor-alpha A Promoter Gene Polymorphism at Position-308 G-->A and Pediatric Inflammatory Bowel Disease: Implications in Ulcerative Colitis and Crohn\u00B4s Disease"@en . . "D\u011Bdek, Petr" . . "[5E27C39C16A2]" . "Our pilot study aimed to determine the effect of tumor necrosis factor-alpha (TNF-alfa) 308 G?A promoter single-nucleotide polymorphism in pediatric inflammatory bowel disease (IBD), its influence on inflammatory activity and the clinical manifestations. METHODS: We obtained genomic DNA from 164 subjects, 82 with long-standing IBD aged 8 to 18 years: 46 with Crohn disease (CD) and 36 with ulcerative colitis (UC). CONCLUSIONS: Although not necessarily dictating IBD initiation, the TNF-alfa 308 A polymorphism may play a role in modifying the CD phenotype. The polymorphism may influence disease activity as well as more intense inflammatory activity in both forms of IBD and may modify the progression of chronic digestive tract inflammation."@en . . "C\u00EDle: na\u0161e pilotn\u00ED studie si dala za c\u00EDl ur\u010Dit \u00FA\u010Dinky jednonukleotidov\u00E9ho promotorov\u00E9ho polymorfizmu tumor-nekrotizuj\u00EDc\u00EDho faktoru-alfa (TNF-alfa) 308 G?A v pediatrick\u00E9 z\u00E1n\u011Btliv\u00E9 chorob\u011B st\u0159ev (IBD), jeho vliv na z\u00E1n\u011Btlivou aktivitu a klinickou manifestaci. Metody: genomick\u00E1 DNA od 164 subjekt\u016F (v\u011Bk 8-18 let) - 82 s dlouhodobou IBD; 46 s Crohnovou chorobou (CD); 36 s ulcerativn\u00ED kolitidou (UC); 82 zdrav\u00FDch kontrol byla genotypov\u00E1na pomoc\u00ED testu restrik\u010Dn\u00EDch enzym\u016F a polymorfizmus byl ur\u010Den ve smyslu aktivity C-reaktivn\u00EDho proteinu a vlastn\u00ED aktivity nemoci. V\u00FDsledky: byly nalezeny v\u00FDznamn\u00E9 rozd\u00EDly v polymorfizmu (TNF-?) 308 G?A mezi IBD a kontrolami a UC a kontrolami. Frekvence TNF-alfa 308 A genotypu byla v\u00FDznamn\u011B vy\u0161\u0161\u00ED u pacient\u016F s CD s penetruj\u00EDc\u00ED chorobou v porovn\u00E1n\u00ED s pacienty bez komplikac\u00ED a zdrav\u00FDmi kontrolami. Distribuce alel a hladiny CRP byly nez\u00E1visle spojeny s CD komplikacemi. Z\u00E1v\u011Bry: TNF-alfa 308 A polymorfizmus m\u016F\u017Ee hr\u00E1t \u00FAlohu p\u0159i modifikaci CD fenotypu"@cs . "S, V" . "9"^^ . "Cytokine; Tumor; Necrosis; Factor-alpha; Promoter; Polymorphism; Position-308; Pediatric; Inflammatory; Bowel; Disease; Implications; Ulcerative; Colitis; Crohn\u00B4s; Disease"@en . . . "11150" . . "RIV/00216208:11150/06:00005147!RIV08-MSM-11150___" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "479;487" . "0277-2116" . . . . "Cytokine Tumor Necrosis Factor-alpha A Promoter Gene Polymorphism at Position-308 G-->A and Pediatric Inflammatory Bowel Disease: Implications in Ulcerative Colitis and Crohn\u00B4s Disease" . . . . .