. . "\u017D\u00E1k, Pavel" . . . . "Pojem myeloproliferativn\u00ED choroby zahrnuje onemocn\u011Bn\u00ED vznikaj\u00EDc\u00ED na z\u00E1klad\u011B malign\u00ED transformace hemopoetick\u00E9 kmenov\u00E9 bu\u0148ky. V\u00FDsledkem transformace je nekontrolovan\u00E1 proliferace hemopoetick\u00E9 kmenov\u00E9 bu\u0148ky s jej\u00ED n\u00E1slednou diferenciac\u00ED. Porucha pluripotentn\u00ED kmenov\u00E9 bu\u0148ky se projevuje abnorm\u00E1ln\u00ED proliferac\u00ED erytrocytov\u00E9, granulocytov\u00E9 a megakaryocytov\u00E9 \u0159ady. S postupem \u010Dasu tak\u00E9 fibrotizac\u00ED kostn\u00ED d\u0159en\u011B a extramedul\u00E1rn\u00ED krvetvorbou (ve slezin\u011B a j\u00E1trech). Nejde obvykle o izolovanou proliferaci jedn\u00E9 \u0159ady, ale v\u011Bt\u0161inou jsou posti\u017Eeny v r\u016Fzn\u00E9m stupni i \u0159ady ostatn\u00ED. Jednotliv\u00E9 choroby z t\u00E9to skupiny onemocn\u011Bn\u00ED jsou geneticky velmi nestabiln\u00ED a vznik dal\u0161\u00EDch zm\u011Bn pak vede k jejich p\u0159echodu do akutn\u00ED leuk\u00E9mie. Podle francouzsko-americko-britsk\u00E9 klasifikace (FAB) se myeloproliferativn\u00ED choroby \u010Dlen\u00ED na: chronickou myeloidn\u00ED leuk\u00E9mii, polycythaemii vera, esenci\u00E1ln\u00ED trombocytemii a idiopatickou myelofibr\u00F3zu (10)."@cs . . . "S" . "CZ - \u010Cesk\u00E1 republika" . "Pr\u00E1\u0161il, Petr" . . "Intern\u00ED medic\u00EDna pro praxi" . . "Cerebral toxoplasmosis in a patient with chronic myeloid leukemia after allogenic unrelated transplantation of haematopoietic cells"@en . . . . "[D1ED48295FE9]" . "Pojem myeloproliferativn\u00ED choroby zahrnuje onemocn\u011Bn\u00ED vznikaj\u00EDc\u00ED na z\u00E1klad\u011B malign\u00ED transformace hemopoetick\u00E9 kmenov\u00E9 bu\u0148ky. V\u00FDsledkem transformace je nekontrolovan\u00E1 proliferace hemopoetick\u00E9 kmenov\u00E9 bu\u0148ky s jej\u00ED n\u00E1slednou diferenciac\u00ED. Porucha pluripotentn\u00ED kmenov\u00E9 bu\u0148ky se projevuje abnorm\u00E1ln\u00ED proliferac\u00ED erytrocytov\u00E9, granulocytov\u00E9 a megakaryocytov\u00E9 \u0159ady. S postupem \u010Dasu tak\u00E9 fibrotizac\u00ED kostn\u00ED d\u0159en\u011B a extramedul\u00E1rn\u00ED krvetvorbou (ve slezin\u011B a j\u00E1trech). Nejde obvykle o izolovanou proliferaci jedn\u00E9 \u0159ady, ale v\u011Bt\u0161inou jsou posti\u017Eeny v r\u016Fzn\u00E9m stupni i \u0159ady ostatn\u00ED. Jednotliv\u00E9 choroby z t\u00E9to skupiny onemocn\u011Bn\u00ED jsou geneticky velmi nestabiln\u00ED a vznik dal\u0161\u00EDch zm\u011Bn pak vede k jejich p\u0159echodu do akutn\u00ED leuk\u00E9mie. Podle francouzsko-americko-britsk\u00E9 klasifikace (FAB) se myeloproliferativn\u00ED choroby \u010Dlen\u00ED na: chronickou myeloidn\u00ED leuk\u00E9mii, polycythaemii vera, esenci\u00E1ln\u00ED trombocytemii a idiopatickou myelofibr\u00F3zu (10)." . "468006" . . . "3"^^ . . "8" . "The notion of myeloproliferative disease includes diseases caused by malign transformation of hemopoietic stem cells. The result of the transformation is an uncontrolled proliferation of hemopoietic stem cell with its following differentiation. The disturbance of the pluripotent stem cell manifests in abnormal proliferation of the erythrocyte, granulocyte and megakaryocyte row, and in the course of time also by fibrotizatiom of bone marrow and extramedular hematopoiesis (in the spleen and in the liver). Usually, it is not an isolated proliferation of one row, but mostly also other rows are afflicted to a varying degree. Single diseases of this group are genetically very unstable and the start of other changes leads to their transfer into acute leukemia. According to French-American-British classification (FAB) the myeloproliferative diseases are divided into: chronic myeloid leukemia, polycythaemia vera, essential thrombocytopenia and idiopathic myelofibrosis."@en . . "Cerebr\u00E1ln\u00ED toxoplasm\u00F3za u nemocn\u00E9ho s chronickou myeloidn\u00ED leuk\u00E9mi\u00ED po alogenn\u00ED nep\u0159\u00EDbuzensk\u00E9 transplantaci krvetvorn\u00FDch bun\u011Bk"@cs . . . "Cerebr\u00E1ln\u00ED toxoplasm\u00F3za u nemocn\u00E9ho s chronickou myeloidn\u00ED leuk\u00E9mi\u00ED po alogenn\u00ED nep\u0159\u00EDbuzensk\u00E9 transplantaci krvetvorn\u00FDch bun\u011Bk" . "Cerebr\u00E1ln\u00ED toxoplasm\u00F3za u nemocn\u00E9ho s chronickou myeloidn\u00ED leuk\u00E9mi\u00ED po alogenn\u00ED nep\u0159\u00EDbuzensk\u00E9 transplantaci krvetvorn\u00FDch bun\u011Bk"@cs . "10" . "462;465" . "Slov\u00E1\u010Dkov\u00E1, Birgita" . . "1212-7299" . "4"^^ . "7"^^ . "Cerebral toxoplasmosis in a patient with chronic myeloid leukemia after allogenic unrelated transplantation of haematopoietic cells"@en . "11150" . . . "Cerebral; toxoplasmosis; patient; chronic; myeloid; leukemia; after; allogenic; unrelated; transplantation; haematopoietic; cells"@en . . . . "Cerebr\u00E1ln\u00ED toxoplasm\u00F3za u nemocn\u00E9ho s chronickou myeloidn\u00ED leuk\u00E9mi\u00ED po alogenn\u00ED nep\u0159\u00EDbuzensk\u00E9 transplantaci krvetvorn\u00FDch bun\u011Bk" . "RIV/00216208:11150/06:00005057" . . "RIV/00216208:11150/06:00005057!RIV08-MSM-11150___" .