. "573-574" . . "[058EF4454EBA]" . . . . "V, Z(MSM0021620820)" . "0003-2670" . "RIV/00216208:11150/06:00004339" . "Kapalinov\u00E1 chromatografie standemovou hmotnostn\u00ED spektrometri\u00ED (LC-MS/MS) vchir\u00E1ln\u00ED studii biotransformace amlodipinu hepatocyty potkana"@cs . . "RIV/00216208:11150/06:00004339!RIV07-MSM-11150___" . "Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes"@en . "NL - Nizozemsko" . . . "Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes" . "1"^^ . "3"^^ . "liquid chromatography; LC-MS/MS; amlodipine; stereoselective metabolism; in vitro"@en . . "11150" . . "Amlodipin je chir\u00E1ln\u00ED blok\u00E1tor kalciov\u00FDch kan\u00E1l\u016F. V klinick\u00E9 praxi se u\u017E\u00EDv\u00E1 racem\u00E1t, a\u010Dkoliv je zn\u00E1mo, \u017Ee vazodilata\u010Dn\u00ED vlastnosti vykazuje pouze S-amlodipin. P\u0159i studiu chir\u00E1ln\u00EDch aspekt\u016F biotransformace byl s hepatocyty potkana inkubov\u00E1n jak racem\u00E1t amlodipinu, tak oba jeho enantiomery. Identifikov\u00E1no a semikvantitativn\u011B stanovov\u00E1no bylo 8 metabolit\u016F p\u0159\u00EDtomn\u00FDch v nejvy\u0161\u0161\u00EDch koncentrac\u00EDch."@cs . "Amlodipine is a chiral calcium channel blocker. Racemic mixture is used in clinical practice even though it is known that only S-amlodipine possess vasodilating properties. Chiral aspects of biotransformation were studied by incubation of amlodipine and its two individual enantiomers with rat hepatocytes. Eight metabolites presented in the highest amount were identified and semiquantified."@en . "Kapalinov\u00E1 chromatografie standemovou hmotnostn\u00ED spektrometri\u00ED (LC-MS/MS) vchir\u00E1ln\u00ED studii biotransformace amlodipinu hepatocyty potkana"@cs . "\u0160i\u0161pera, Lud\u011Bk" . . "2006" . "Analytica Chimica Acta" . . . "Amlodipine is a chiral calcium channel blocker. Racemic mixture is used in clinical practice even though it is known that only S-amlodipine possess vasodilating properties. Chiral aspects of biotransformation were studied by incubation of amlodipine and its two individual enantiomers with rat hepatocytes. Eight metabolites presented in the highest amount were identified and semiquantified." . "273;283" . "483414" . . . . "Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes" . "Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes"@en . "11"^^ . . .