. "Journal of Chromatography B" . . "6"^^ . "478306" . . "107;112" . . . . "HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study"@en . "1570-0232" . "Popelov\u00E1, Olga" . "RIV/00216208:11150/06:00004336" . "RIV/00216208:11150/06:00004336!RIV07-MSM-11150___" . . "\u0160t\u011Brba, Martin" . "Ger\u0161l, Vladim\u00EDr" . . . . "838" . . "HPLC; pyridoxal 2-chlorobenzoyl hydrazone; iron chelator; pharmacokinetics"@en . "6"^^ . "HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study"@en . . "[9B7E560EF761]" . "2" . . "V t\u00E9to studii byla vyvinuta a validov\u00E1na HPLC metoda pro stanoven\u00ED biokompatibiln\u00EDho chel\u00E1toru \u017Eeleza pyridoxal 2-chlorbenzoylhydrazonu v kr\u00E1li\u010D\u00ED plasm\u011B. Separace bylo dosa\u017Eeno na C18 kolon\u011B s mobiln\u00ED f\u00E1z\u00ED skl\u00E1daj\u00EDc\u00ED se ze sm\u011Bsi fosf\u00E1tov\u00E9ho pufru (0,01 M, pH 6) s p\u0159\u00EDdavkem EDTA (2 mM), methanolu a acetonitrilu (42:24:14; v/v/v). Tato metoda byla \u00FAsp\u011B\u0161n\u011B aplikov\u00E1na do anal\u00FDzy vzork\u016F z\u00EDskan\u00FDch z pilotn\u00EDho farmakokinetick\u00E9ho experimentu, v kter\u00E9m byl chel\u00E1tor pod\u00E1v\u00E1n intraven\u00F3zn\u011B kr\u00E1l\u00EDk\u016Fm."@cs . "HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study" . . "In this study a high performance liquid chromatographic method for the determination of a biocompatible iron chelator, pyridoxal 2-chlorobenzoyl hydrazone (o-108), in rabbit plasma was developed and validated. The separation was achieved on a C18 column with the mobile phase composed of a mixture of 0.01 M phosphate buffer (pH 6) with the addition of EDTA (2 mM), methanol and acetonitrile (42:24:14; v/v/v). This method was successfully applied to the analysis of the samples obtained from a pilot pharmacokinetic experiment, in which the chelator was administered intravenously to rabbits." . . "HPLC stanoven\u00ED nov\u00E9ho aroylhydrazonov\u00E9ho chel\u00E1toru (o-108) v kr\u00E1li\u010D\u00ED plasm\u011B a jeho aplikace do pilotn\u00EDho farmakokinetick\u00E9 studie"@cs . . . "3"^^ . "V, Z(MSM0021620820), Z(MSM0021620822)" . "In this study a high performance liquid chromatographic method for the determination of a biocompatible iron chelator, pyridoxal 2-chlorobenzoyl hydrazone (o-108), in rabbit plasma was developed and validated. The separation was achieved on a C18 column with the mobile phase composed of a mixture of 0.01 M phosphate buffer (pH 6) with the addition of EDTA (2 mM), methanol and acetonitrile (42:24:14; v/v/v). This method was successfully applied to the analysis of the samples obtained from a pilot pharmacokinetic experiment, in which the chelator was administered intravenously to rabbits."@en . "HPLC stanoven\u00ED nov\u00E9ho aroylhydrazonov\u00E9ho chel\u00E1toru (o-108) v kr\u00E1li\u010D\u00ED plasm\u011B a jeho aplikace do pilotn\u00EDho farmakokinetick\u00E9 studie"@cs . . . "NL - Nizozemsko" . . "HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study" . "11150" .