. . . "11150" . . . . . "[CA683FAD1DD8]" . "Atorvastatin slows down the deterioration of inner ear function with age in mice" . "RIV/00216208:11150/06:00004214!RIV08-MSM-11150___" . "4"^^ . "statins; presbycusis; C57BL/6J mouse; apoE; mouse; distortion product otoacoustic emissions; outer hair cells"@en . "Atorvastatin slows down the deterioration of inner ear function with age in mice"@en . "112;116" . . . "Atorvastatin slows down the deterioration of inner ear function with age in mice" . . . "Atorvastatin zpomaluje po\u0161kozen\u00ED funkce vnit\u0159n\u00EDho ucha zp\u016Fsoben\u00E9 v\u011Bkem u my\u0161i"@cs . "1"^^ . . "Here, we describe the effects of statins on the treatment of presbycusis in C57BL/6J mice. In this strain with accelerated aging, we demonstrate that animals treated with atorvastatin for 2 months showed larger amplitudes of distortion product otoacoustic emissions than did the non-treated control group. This finding indicates a better survival of outer hair cell function in the inner ear of C57BL/6J mice. The observed decreased expression of intercellular and vascular adhesion molecules in the aortic wall of atorvastatin-treated animals suggests that reducing endothelial inflammatory effects may contribute to the positive effect of atorvastatin on the amplitudes of DPOAE by influencing the blood supply to the inner ear. No such beneficial effect of statins was found in apoE-/- mice treated with atorvastatin under the same conditions. Our results suggest that statins could also slow down the age-related deterioration of hearing in man."@en . . "0304-3940" . . . . "Solichov\u00E1, Dagmar" . . "Here, we describe the effects of statins on the treatment of presbycusis in C57BL/6J mice. In this strain with accelerated aging, we demonstrate that animals treated with atorvastatin for 2 months showed larger amplitudes of distortion product otoacoustic emissions than did the non-treated control group. This finding indicates a better survival of outer hair cell function in the inner ear of C57BL/6J mice. The observed decreased expression of intercellular and vascular adhesion molecules in the aortic wall of atorvastatin-treated animals suggests that reducing endothelial inflammatory effects may contribute to the positive effect of atorvastatin on the amplitudes of DPOAE by influencing the blood supply to the inner ear. No such beneficial effect of statins was found in apoE-/- mice treated with atorvastatin under the same conditions. Our results suggest that statins could also slow down the age-related deterioration of hearing in man." . "NL - Nizozemsko" . . "RIV/00216208:11150/06:00004214" . . "V t\u00E9to zpr\u00E1v\u011B popisujeme \u00FA\u010Dinky statin\u016F na l\u00E9\u010Dbu presbyakuzie u C57BL/6J my\u0161\u00ED. U tohoto kmene se zrychlen\u00FDm st\u00E1rnut\u00EDm ukazujeme, \u017Ee zv\u00ED\u0159ata l\u00E9\u010Den\u00E1 atorvastatinem po dobu 2 m\u011Bs\u00EDc\u016F vykazovala v\u011Bt\u0161\u00ED amplitudy v testu otoakoustick\u00FDch emis\u00ED V porovn\u00E1n\u00ED s nel\u00E9\u010Denou skupinou. Toto zji\u0161t\u011Bn\u00ED nazna\u010Duje lep\u0161\u00ED zachov\u00E1n\u00ED funkc\u00ED vn\u011Bj\u0161\u00EDch vl\u00E1skov\u00FDch bun\u011Bk ve vnit\u0159n\u00EDm uchu C57BL/6J my\u0161\u00ED. Pozorovan\u00E1 sn\u00ED\u017Een\u00E1 exprese intercelul\u00E1rn\u00EDch a vaskul\u00E1rn\u00EDch adhezivn\u00EDch molekul ve st\u011Bn\u011B aorty atorvastatinem l\u00E9\u010Den\u00FDch zv\u00ED\u0159at nazna\u010Duje, \u017Ee redukce endoteli\u00E1ln\u00EDch z\u00E1n\u011Btliv\u00FDch \u00FA\u010Dink\u016F m\u016F\u017Ee p\u0159isp\u00EDvat k pozitivn\u00EDmu \u00FA\u010Dinku atorvastatinu na amplitudy DPOAE pomoc\u00ED ovlivn\u011Bn\u00ED dod\u00E1vek krve do vnit\u0159n\u00EDho ucha. \u017D\u00E1dn\u00FD takov\u00FD pozitivn\u00ED \u00FA\u010Dinek statin\u016F nebyl objeven u ApoE/- my\u0161\u00ED l\u00E9\u010Den\u00FDch atorvastatinem za stejn\u00FDch podm\u00EDnek. Na\u0161e v\u00FDsledky poukazuj\u00ED na fakt, \u017Ee statiny by tak\u00E9 mohly zpomalovat v\u011Bkem zp\u016Fsobenou zhor\u0161enou sluchovou funkci u \u010Dlov\u011Bka."@cs . "5"^^ . . "2" . . "411" . "Neuroscience Letters" . . . "Atorvastatin slows down the deterioration of inner ear function with age in mice"@en . . "411004" . . . "Atorvastatin zpomaluje po\u0161kozen\u00ED funkce vnit\u0159n\u00EDho ucha zp\u016Fsoben\u00E9 v\u011Bkem u my\u0161i"@cs . "P(GA309/04/1074), P(GP304/03/P049), P(LC554), P(NR8113), S, V, Z(AV0Z50390512)" .