"Present View on the Stem Cell Plasticity and Cell Therapy"@en . "Mokr\u00FD, Jaroslav" . . "Filip, Stanislav" . . "Jedn\u00EDm z nejsporn\u011Bj\u0161\u00EDch probl\u00E9m\u016F v sou\u010Dasn\u00E9 biologii a medic\u00EDn\u011B je existence plasticity kmenov\u00FDch bun\u011Bk. Experiment\u00E1ln\u00ED biologie a medic\u00EDna pracuje s kmenov\u00FDmi bu\u0148kami a s vyu\u017Eit\u00EDm bun\u011B\u010Dn\u00E9 terapie ji\u017E v\u00EDce ne\u017E 20 let. Term\u00EDnem plasticita se m\u00EDn\u00ED fenotypov\u00FD potenci\u00E1l kmenov\u00FDch bun\u011Bk, kter\u00FD je \u0161ir\u0161\u00ED, ne\u017E jsou fenotypy diferencovan\u00FDch bun\u011Bk jejich p\u016Fvodn\u00EDch tk\u00E1n\u00ED. Mnoho laborato\u0159\u00ED ji\u017E podalo d\u016Fkaz o existenci plasticity kmenov\u00FDch bun\u011Bk, ale vznikla cel\u00E1 \u0159ada n\u00E1mitek k prezentovan\u00FDm v\u00FDsledk\u016Fm. Prezentujeme n\u011Bkter\u00E9 z n\u00E1mitek zpochyb\u0148uj\u00EDc\u00ED \u00FAdaje o plasticit\u011B kmenov\u00FDch bun\u011Bk. Ve sd\u011Blen\u00ED chceme pouk\u00E1zat na n\u011Bkter\u00E9 ot\u00E1zky a probl\u00E9my spojen\u00E9 s plasticitou kmenov\u00FDch bun\u011Bk, ot\u00E1zkami transdiferenciace a f\u00FAze bun\u011Bk. Z dosavadn\u00EDch experiment\u00E1ln\u00EDch v\u00FDsledk\u016F m\u016F\u017Eeme \u0159\u00EDci, \u017Ee kmenov\u00E9 bu\u0148ky budou m\u00EDt kl\u00ED\u010Dovou \u00FAlohu v bun\u011B\u010Dn\u00E9 terapii. Toto sd\u011Blen\u00ED p\u0159edstavuje ur\u010Ditou sondu a \u00FAvod do diskuze ur\u010Den\u00E9 pro plasticitu kmenov\u00FDch bun\u011Bk a bun\u011B\u010Dnou terapii." . "The most controversial problem in the present biology and medicine is the existence of stem cell plasticity. Experimental biology and medicine have been working with stem cells and stem cell therapy more than twenty years. The term plasticity, as it is understood, is the potential of stem cell phenotypes that is much broader that phenotypes of differentiated cells of their original tissues. Many laboratories have documented the existence of stem cell plasticity; however, many objections to the reported results still exist. Here, we present some of these objections questioning the data on stem cell plasticity. We wish to point out some problems associated with plasticity of stem cells, transdifferentiation and cell fusion. Recent experimental results indicate that stem cells may have a key role in stem cell therapy. This review is an introductory discussion on the stem cell plasticity and stem cell therapy."@en . "779;783" . "Sou\u010Dasn\u00FD pohled na plasticitu kmenov\u00FDch bun\u011Bk a bun\u011B\u010Dnou terapii"@cs . . . "144" . "\u010Casopis l\u00E9ka\u0159\u016F \u010Desk\u00FDch" . "5"^^ . "12" . . . "Present; Plasticity; Therapy"@en . "S" . "Present View on the Stem Cell Plasticity and Cell Therapy"@en . "Sou\u010Dasn\u00FD pohled na plasticitu kmenov\u00FDch bun\u011Bk a bun\u011B\u010Dnou terapii" . . "RIV/00216208:11150/05:00004944!RIV08-MSM-11150___" . . . . "3"^^ . . . "Jedn\u00EDm z nejsporn\u011Bj\u0161\u00EDch probl\u00E9m\u016F v sou\u010Dasn\u00E9 biologii a medic\u00EDn\u011B je existence plasticity kmenov\u00FDch bun\u011Bk. Experiment\u00E1ln\u00ED biologie a medic\u00EDna pracuje s kmenov\u00FDmi bu\u0148kami a s vyu\u017Eit\u00EDm bun\u011B\u010Dn\u00E9 terapie ji\u017E v\u00EDce ne\u017E 20 let. Term\u00EDnem plasticita se m\u00EDn\u00ED fenotypov\u00FD potenci\u00E1l kmenov\u00FDch bun\u011Bk, kter\u00FD je \u0161ir\u0161\u00ED, ne\u017E jsou fenotypy diferencovan\u00FDch bun\u011Bk jejich p\u016Fvodn\u00EDch tk\u00E1n\u00ED. Mnoho laborato\u0159\u00ED ji\u017E podalo d\u016Fkaz o existenci plasticity kmenov\u00FDch bun\u011Bk, ale vznikla cel\u00E1 \u0159ada n\u00E1mitek k prezentovan\u00FDm v\u00FDsledk\u016Fm. Prezentujeme n\u011Bkter\u00E9 z n\u00E1mitek zpochyb\u0148uj\u00EDc\u00ED \u00FAdaje o plasticit\u011B kmenov\u00FDch bun\u011Bk. Ve sd\u011Blen\u00ED chceme pouk\u00E1zat na n\u011Bkter\u00E9 ot\u00E1zky a probl\u00E9my spojen\u00E9 s plasticitou kmenov\u00FDch bun\u011Bk, ot\u00E1zkami transdiferenciace a f\u00FAze bun\u011Bk. Z dosavadn\u00EDch experiment\u00E1ln\u00EDch v\u00FDsledk\u016F m\u016F\u017Eeme \u0159\u00EDci, \u017Ee kmenov\u00E9 bu\u0148ky budou m\u00EDt kl\u00ED\u010Dovou \u00FAlohu v bun\u011B\u010Dn\u00E9 terapii. Toto sd\u011Blen\u00ED p\u0159edstavuje ur\u010Ditou sondu a \u00FAvod do diskuze ur\u010Den\u00E9 pro plasticitu kmenov\u00FDch bun\u011Bk a bun\u011B\u010Dnou terapii."@cs . . "RIV/00216208:11150/05:00004944" . "[C895E92C6A5A]" . "3"^^ . "11150" . . "0008-7335" . . "CZ - \u010Cesk\u00E1 republika" . "Pudil, Radek" . . "Sou\u010Dasn\u00FD pohled na plasticitu kmenov\u00FDch bun\u011Bk a bun\u011B\u010Dnou terapii" . "Sou\u010Dasn\u00FD pohled na plasticitu kmenov\u00FDch bun\u011Bk a bun\u011B\u010Dnou terapii"@cs . "543644" .