. "Thalidomide"@en . "Thalidomid"@cs . "Klinick\u00E1 farmakologie a farmacie" . "1212-7973" . "S" . . "RIV/00216208:11150/05:00004750" . "19" . . "43;46" . "Maisnar, Vladim\u00EDr" . . "The era of novel biologically-based therapies for MM began in the late 1990s with the finding of a strong anti-myeloma effect of thalidomide and the finding that bone marrow microenvironment plays a key role in promoting growth, survival, drug resistance, and migration of myeloma cells. Novel therapies in myeloma represented by thalidomide interfere with these processes in a variety of ways. They inhibit myeloma growth and induce cell death. Newer therapies are known as antiangiogenic drugs and/or immunomodulatory drugs (IMiDs). Thalidomide was shown extraordinarity clinically effective in patients with multiple myeloma. This drug is also being evaluated in other haematological and solid tumours. Worldwide thalidomide is on routinely used in relapsed patients with multiple myeloma as monotherapy or in combination with corticosteroids. Treatment of other cancers has so far been only experimental despite promising results in other heamatological and in solid malignancies."@en . "Thalidomid" . . "Na konci minul\u00E9ho stolet\u00ED byl zji\u0161t\u011Bn v\u00FDrazn\u00FD protimyelomov\u00FD \u00FA\u010Dinek u thalidomidu, reprezentuj\u00EDc\u00EDho nov\u00FD typ protin\u00E1dorov\u00FDch tzv. \u201Ebiological based\u201C l\u00E9k\u016F. Tato nejnov\u011Bj\u0161\u00ED generace l\u00E9k\u016F s protimyelomov\u00FDm \u00FA\u010Dinkem interferuje s jednou nebo v\u00EDce reakcemi \u010Di vazbami mezi n\u00E1dorovou bu\u0148kou a jej\u00EDm okol\u00ED. Blokuje tak r\u016Fst myelomov\u00FDch bun\u011Bk a myelomov\u00E9 bu\u0148ky jsou sm\u011B\u0159ov\u00E1ny ke smrti. Tyto l\u00E9\u010Debn\u00E9 p\u0159\u00EDpravky jsou dnes ozna\u010Dov\u00E1ny pojmy antiangiogenn\u00ED a/nebo imunomodula\u010Dn\u00ED (IMiDs \u2013 immunomodulatory drugs) l\u00E9ky. Thalidomid prok\u00E1zal mimo\u0159\u00E1dnou \u00FA\u010Dinnost u nemocn\u00FDch s mnoho\u010Detn\u00FDm myelomem. Je testov\u00E1n i u \u0159ady dal\u0161\u00EDch hematologick\u00FDch a onkologick\u00FDch diagn\u00F3z. V monoterapii nebo v kombinaci s kortikoidy je dnes rutinn\u011B pou\u017E\u00EDv\u00E1n v l\u00E9\u010Db\u011B relapsu mnoho\u010Detn\u00E9ho myelomu na cel\u00E9m sv\u011Bt\u011B. Jeho pou\u017Eit\u00ED u dal\u0161\u00EDch hematologick\u00FDch n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED a rovn\u011B\u017E tak solidn\u00EDch n\u00E1dor\u016F je prozat\u00EDm jen experiment\u00E1ln\u00ED." . "4"^^ . "Thalidomid"@cs . "11150" . . "Na konci minul\u00E9ho stolet\u00ED byl zji\u0161t\u011Bn v\u00FDrazn\u00FD protimyelomov\u00FD \u00FA\u010Dinek u thalidomidu, reprezentuj\u00EDc\u00EDho nov\u00FD typ protin\u00E1dorov\u00FDch tzv. \u201Ebiological based\u201C l\u00E9k\u016F. Tato nejnov\u011Bj\u0161\u00ED generace l\u00E9k\u016F s protimyelomov\u00FDm \u00FA\u010Dinkem interferuje s jednou nebo v\u00EDce reakcemi \u010Di vazbami mezi n\u00E1dorovou bu\u0148kou a jej\u00EDm okol\u00ED. Blokuje tak r\u016Fst myelomov\u00FDch bun\u011Bk a myelomov\u00E9 bu\u0148ky jsou sm\u011B\u0159ov\u00E1ny ke smrti. Tyto l\u00E9\u010Debn\u00E9 p\u0159\u00EDpravky jsou dnes ozna\u010Dov\u00E1ny pojmy antiangiogenn\u00ED a/nebo imunomodula\u010Dn\u00ED (IMiDs \u2013 immunomodulatory drugs) l\u00E9ky. Thalidomid prok\u00E1zal mimo\u0159\u00E1dnou \u00FA\u010Dinnost u nemocn\u00FDch s mnoho\u010Detn\u00FDm myelomem. Je testov\u00E1n i u \u0159ady dal\u0161\u00EDch hematologick\u00FDch a onkologick\u00FDch diagn\u00F3z. V monoterapii nebo v kombinaci s kortikoidy je dnes rutinn\u011B pou\u017E\u00EDv\u00E1n v l\u00E9\u010Db\u011B relapsu mnoho\u010Detn\u00E9ho myelomu na cel\u00E9m sv\u011Bt\u011B. Jeho pou\u017Eit\u00ED u dal\u0161\u00EDch hematologick\u00FDch n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED a rovn\u011B\u017E tak solidn\u00EDch n\u00E1dor\u016F je prozat\u00EDm jen experiment\u00E1ln\u00ED."@cs . . "Thalidomide"@en . . "1"^^ . . "Thalidomid" . "3"^^ . "Thalidomide"@en . . "546583" . . "[C9F110F0CAF5]" . "1" . "CZ - \u010Cesk\u00E1 republika" . . "RIV/00216208:11150/05:00004750!RIV08-MSM-11150___" .