"RIV/00216208:11150/05:00003602!RIV06-MSM-11150___" . "Ehler, Edvard" . "8"^^ . "165;172" . . . "The changes of peripheral nerve microsutructure after surgical manipulation - experiment on rat model"@en . "1211-4286" . "[BEC589A26C5C]" . . "514934" . . "Zm\u011Bny v mikrostruktu\u0159e perifern\u00EDho nervu po chirurgick\u00E9 manipulaci - experiment na kryse"@cs . "The changes of peripheral nerve microsutructure after surgical manipulation - experiment on rat model"@en . "N\u011Bme\u010Dek, Stanislav" . . . "The aim of our study was to describe histopathology of the peripheral nerve after its circular release followed by embedding in different environs. We operated on 18 male rats divided into 3 groups. In the first group right femoral nerve was surgically released. In the second group the nerve was enveloped by the subcutaneous fat flap. In the third one the nerve was wrapped up by the skeletal muscle. Six weeks later the animals wire killed by exsanguination. The femoral nerve, in the first group, did not show any pathological changes. In the second group 3 animals appeared normal or nerarly normal, nevertheless in 3 of them perineural fibrosis and axonal degeneration were observed. Histological reaction in the third group disclosed dispersed axonal injury. Our experiments using rat model imitate situation in humans. The results obtained will help us in making meaningful decision when performing peripheral nerve injury."@en . . . "Zm\u011Bny v mikrostruktu\u0159e perifern\u00EDho nervu po chirurgick\u00E9 manipulaci - experiment na kryse"@cs . "The changes of peripheral nerve microsutructure after surgical manipulation - experiment on rat model" . "11150" . . "48" . . "Nerve microstructure; perineural fibrosis; axonal damage; animals models; nerve histology"@en . "Cerman, Jaroslav" . "RIV/00216208:11150/05:00003602" . . "The changes of peripheral nerve microsutructure after surgical manipulation - experiment on rat model" . . . . "The aim of our study was to describe histopathology of the peripheral nerve after its circular release followed by embedding in different environs. We operated on 18 male rats divided into 3 groups. In the first group right femoral nerve was surgically released. In the second group the nerve was enveloped by the subcutaneous fat flap. In the third one the nerve was wrapped up by the skeletal muscle. Six weeks later the animals wire killed by exsanguination. The femoral nerve, in the first group, did not show any pathological changes. In the second group 3 animals appeared normal or nerarly normal, nevertheless in 3 of them perineural fibrosis and axonal degeneration were observed. Histological reaction in the third group disclosed dispersed axonal injury. Our experiments using rat model imitate situation in humans. The results obtained will help us in making meaningful decision when performing peripheral nerve injury." . . "CZ - \u010Cesk\u00E1 republika" . "4"^^ . "3" . . "Acta Medica (Hradec Kr\u00E1lov\u00E9)" . . . "P(IAA148404), P(NR8404), Z(MSM0021620820)" . . . "Kanta, Martin" . . "C\u00EDlem pr\u00E1ce bylo popsat histologick\u00E9 zm\u011Bny perifern\u00EDch nerv\u016F po jejich uvoln\u011Bn\u00ED a ulo\u017Een\u00ED do r\u016Fzn\u00FDch tk\u00E1n\u00ED. Operovali jsme 18 krys (samci) rozd\u011Blen\u00FDch do 3 skupin. V prvn\u00ED jsme uvolnili n. femoralis vpravo, ve druh\u00E9 byl nerv obalen podko\u017En\u00EDm tukem, ve t\u0159et\u00ED byl ulo\u017Een do p\u0159\u00ED\u010Dn\u011B pruhovan\u00E9ho svalu. Zv\u00ED\u0159ata byla utracena po 6 t\u00FDdnech exsanquinac\u00ED. V prvn\u00ED skupin\u011B n. femoralis nevyk\u00E1zal \u017E\u00E1dn\u00E9 patologick\u00E9 zm\u011Bny, ve druh\u00E9 skupin\u011B byl n\u00E1lez u 3 zv\u00ED\u0159at norm\u00E1ln\u00ED nebo skoro norm\u00E1ln\u00ED a u 3 z nich jsme nalezli perineur\u00E1ln\u00ED fibr\u00F3zu a degeneraci axonu. Histologick\u00E9 vy\u0161et\u0159en\u00ED ve t\u0159et\u00ED skupin\u011B prok\u00E1zalo po\u0161kozen\u00ED axonu. Experimenty napodobuj\u00ED situaci u nemocn\u00FDch a z\u00EDskan\u00E9 v\u00FDsledky pomohou v rozhodov\u00E1n\u00ED o l\u00E9\u010Db\u011B poran\u011Bn\u00ED perifern\u00EDch nerv\u016F."@cs . "4"^^ . . .